Tigers vs Guardians Picks, Prediction for 9/23/25: Bounceback for Tarik Skubal?

From the Department of Nobody Saw it Coming, the piping hot Cleveland Guardians — winners of nine out of 10 — now sit a single game behind the slumping Detroit Tigers, losers of nine of their last 10.

Tonight, the Tigers trot out ace Tarik Skubal, who is 6-3 against the Guardians since 2022. The Guardians counter with righty Gavin Williams.

Whether you’re backing pitchers' earned runs or a hitter’s total bases, Monday's MLB slate is stacked with opportunities on PrizePicks to pick More or Less and cash in.

PrizePicks MLB Picks Tigers vs Guardians: Tuesday, September 23

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Tigers P Tarik Skubal: 8 Strikeouts

• In his last 119 batters faced, Tarik Skubal has allowed an 8% barrel rate, a 40% hard-hit rate, and an ugly 30% fly ball rate.
• Across his last nine innings pitched, Skubal has surrendered 5 earned runs, a rare stumble for the Cy Young candidate.
• Against left-handed pitching in their last 225 plate appearances, the Cleveland Guardians have a .283 BABIP, a nearly 10% barrel rate, a 47% hard-hit rate, and a 23% fly ball rate.
• In his last three starts against Cleveland, Skubal has struck out 13, 10, and 9 batters.

Guardians P Gavin Williams: 29.5 Pitcher Fantasy Score

• Of his last 117 batters faced, Williams has given up a 9% barrel rate, a massive 68% hard-hit percentage, and a 25% fly ball rate.
• Over his last 25 innings pitched, Williams allowed just 3 earned runs while striking out 26 batters.
• Against right-handed pitching over their last 567 plate appearances, the Detroit Tigers own a .286 BABIP, a 10% barrel rate, a 50% hard-hit rate, and a 30% fly ball rate.
• In his last four starts vs. the Tigers, Williams has racked up 9, 8, 8, and 9 strikeouts.

Guardians OF Jhonkensy Noel: 0.5 Hits+Runs +RBIs

• In his last 21 plate appearances against left-handed pitching, Noel is flashing a 40% fly ball rate, a 92% hard-hit rate, and a 15% barrel rate, resulting in a .300 BABIP.
• In the month of September, Noel is slashing .220 with 3 home runs.
• Noel is the only hitter in the Guardians lineup to have homered off Skubal.

Make MLB DFS Picks on PrizePicks

Tuesday's Tigers vs. Guardians game provides plenty of MLB action to make your predictions as we get into the heat of the MLB playoff positioning and divisional chase.

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