Tigers vs. Blue Jays Prediction, MLB Picks for Wednesday, September 16

In a closely contested AL Wild Card race, the Detroit Tigers (72-79) and Toronto Blue Jays (75-77) wrap up their three-game series at 3:07 p.m. ET on Wednesday, September 16. The Blue Jays are home favorites, with a win returning a 1.69x payout on PrizePicks.

On Tuesday, Detroit broke out its bats in a 10-1 win against Toronto and continued to climb in the standings. Now, the Tigers are just 4.5 games back of the final Wild Card spot in the American League while trailing by five games in the AL Central division race.

Below, we'll break down our Tigers vs. Blue Jays prediction and picks for Wednesday’s MLB matchup, including the run line, over/under, and key player picks for PrizePicks.

Make your Tigers vs. Blue Jays picks on PrizePicks now.

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Tigers vs. Blue Jays Prediction, Winner Payout, Over/Under – Wednesday, September 16

The Blue Jays are slated to send SP Max Scherzer to the mound on Wednesday afternoon as they hope to salvage a game in the series.

At 42, Scherzer has shown that his best days may be behind him, posting a 2-8 record and a 6.38 ERA in 67.2 innings. The veteran right-hander is coming off an outing in which he surrendered six earned runs on seven hits in just 5.0 innings against the Baltimore Orioles.

According to Baseball Savant, Scherzer has recorded a 4.43 xERA (33rd percentile), a 17.3% strikeout rate (14th percentile), and just a 93.1 mph fastball velocity (28th percentile). He has also issued his fair share of free passes with a 9.5% walk rate this season.

Meanwhile, SP Keider Montero will toe the rubber for the Tigers and look to continue what has been a strong campaign so far. 

Montero has compiled a strong 3.55 ERA across a career-high 147.0 innings and has held opponents to a .231 xBA (62nd percentile). The right-hander has also registered a 37.1% hard-hit rate (60th percentile) and a 3.56 xERA (73rd percentile).

Montero has yielded 2 or fewer earned runs in three of his last five starts but doesn’t rely on power pitches to get hitters out. In fact, he’s tallied just a 16.5% strikeout rate, which ranks in the 10th percentile. 

Offensively, the Tigers have posted the 15th-ranked wRC+ (100) in the majors, while the Blue Jays rank 23rd with a 96 wRC+, per FanGraphs.

This season, Detroit ranks 15th in runs scored (682), averaging 4.52 runs per contest. Meanwhile, Toronto ranks last in the majors with just 4.04 runs per game.

Tigers vs. Blue Jays Winner Payout, Over/Under – Wednesday, September 16

The Blue Jays enter Wednesday’s game as a home favorite against the Tigers, returning a 1.69x payout if they win outright, via PrizePicks.

Here are the full payouts for the Tigers vs. Blue Jays game on PrizePicks.

Make your Tigers vs. Blue Jays prediction on the over/under on PrizePicks.

PrizePicks data is live at the time of writing and is subject to change.

Tigers vs. Blue Jays Prediction on Winner – 9/16/26

Here are the key game stats and trends behind our Tigers vs. Blue Jays winner prediction for Wednesday, September 16.

• The Tigers are 4-2 against the Blue Jays in their last six matchups, including outscoring Toronto 16-6 in the first two games of the series.
• Blue Jays SP Max Scherzer has a 1-3 record and a 6.07 ERA in his last five starts. 
• Scherzer has also allowed at least 6 earned runs in two of those outings and issued 11 walks during that stretch.
• Toronto has averaged just 3.0 runs in its last six meetings against Detroit.
• The Tigers have won six of SP Keider Montero’s last 10 starts.
• Montero has had a track record of keeping the ball in the yard, recording just an 8.3% home-run-to-fly-ball rate.
• Detroit has tallied the eighth-best OBP (.336) in the league in September. 

Lock in your Tigers vs. Blue Jays prediction on PrizePicks now.

Tigers vs. Blue Jays Picks, Player Stats for PrizePicks: 9/16/26

Here are the top Tigers vs. Blue Jays picks to target on Wednesday, September 16. Today’s MLB picks for PrizePicks include Riley Greene and George Springer.

Tigers OF Riley Greene vs. Blue Jays: 6 Fantasy Score

• Greene is hitting .476 (10-for-21) with a home run, 7 RBIs, and 5 runs in his last five games.
• The Tigers outfielder has thrived against right-handed pitching in 2026, posting a .293 average and slugging 15 of his 20 home runs.
• Greene has recorded a 15.3% barrel rate, which ranks in the 95th percentile.
• The three-time All-Star has also posted a 48.0% hard-hit rate this year, ranking in the 86th percentile.

Add Riley Greene to your PrizePicks lineup now.

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Blue Jays OF George Springer vs. Tigers: 5.5 Fantasy Score

• Springer is hitting .400 (8-for-20) with a home run, 4 RBIs, and 4 runs across his last five games.
• The Blue Jays’ slugger has recorded just a 23.2% whiff rate (53rd percentile).
• Despite producing a .253 average, Springer is hitting .272 vs. right-handed pitching, with 11 of his 15 home runs coming against righties.
• Springer has registered at least a hit in each of his last five contests, including three multi-hit games. 

Add George Springer to your PrizePicks lineup now.

Make Tigers vs. Blue Jays Picks on PrizePicks

This is an extremely pivotal contest between the Detroit Tigers and Toronto Blue Jays in the American League playoff race. Can the Tigers come away with a sweep north of the border? 

Don’t wait until the first pitch — make your Tigers vs. Blue Jays picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on MLB game winners, spreads, and over/unders, now available in 36 states.

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