South Carolina vs. #8 Alabama Prediction, Spread, NCAAF Picks – Saturday, September 26

South Carolina and #8 Alabama will duke it out in an SEC showdown in Week 4 of the college football season on Saturday, September 26, at 7 p.m. ET on ESPN. Ahead of Saturday’s kickoff, the Crimson Tide are 11.5-point home favorites on PrizePicks.

In Week 3 against #24 Mississippi State, South Carolina suffered its first defeat, losing 41-34. Alabama, meanwhile, improved to 3-0 on the season with a 50-36 victory over Florida State last weekend.

Below, we'll break down our South Carolina vs. #8 Alabama prediction and picks for Saturday’s college football game, including the spread, over/under, and key player picks on PrizePicks.

Make your South Carolina vs. Alabama prediction on PrizePicks now!

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South Carolina vs. #8 Alabama Prediction, Spread, Over/Under – Saturday, September 26

With QB LaNorris Sellers returning for another season on the Gamecocks, South Carolina’s offense is in the 89th percentile in passing success rate (55.8%) and 83rd percentile in EPA/pass (0.36), per Game on Paper. Sellers is also contributing the second-most rushing yards (172) on the Gamecocks; they’ll need his legs to threaten the Crimson Tide’s defense.

In the loss to Mississippi State, South Carolina converted only 33.3% of its 18 third downs, and Sellers tossed 2 INTs. Avoiding three-and-outs and taking care of the football will be paramount for the Gamecocks on the road in a hostile environment in Week 4. 

Along with Alabama residing in the 86th percentile in passing success rate (53.9%) following QB Keelon Russell replacing QB Ty Simpson, the Crimson Tide are in the 75th percentile in rush EPA/play (0.17) with Russell and RB Daniel Hill leading the charge.

Although Alabama limited Florida State to 94 rushing yards on 2.7 yards per attempt in Week 3, South Carolina will be the most effective rushing attack it's faced. The good news is that the Crimson Tide sit in the 87th percentile in rush EPA/play (-0.16) allowed.

A ton of pressure rests on the shoulders of head coach Kalen DeBoer to deliver success for Alabama, and a correct prediction of "Yes" for the Crimson Tide to make the College Football Playoff returns a 2.22x payout on PrizePicks. Meanwhile, "No" returns a 1.61x payout.

South Carolina vs. Alabama Spread, Over/Under – Saturday, September 26

Alabama enters Saturday’s game as an 11.5-point home favorite against South Carolina, returning a 1.17x payout on PrizePicks if they win outright.

Here are the full payouts for the South Carolina vs. #8 Alabama game on PrizePicks.

Make your South Carolina vs. Alabama pick on the spread or over/under on PrizePicks.

Payouts show potential returns on correct PrizePicks predictions. A 2x payout returns $200 on a $100 entry. Lower multipliers reflect outcomes users are picking as more likely. Payouts are live as of writing and subject to change.

South Carolina vs. Alabama Prediction on Over/Under – 9/26/26

Here are the key game stats and trends behind our South Carolina vs. Alabama prediction on the total for Saturday, September 26’s game. 

• Among 138 FBS college football teams, South Carolina is fourth in offensive success rate (57.0%). In the same sample, Alabama is 10th (55.3%).
• Both of these teams excel at keeping drives alive, with the Gamecocks in the 86th percentile in late-down success rate (56.7%) and the Crimson Tide in the 92nd percentile (58.5%)
• The over is 4-0 in the last four meetings between South Carolina and Alabama.
• The Crimson Tide have started a perfect 3-0 to the over, and their lone SEC matchup against Kentucky in Week 2 featured 62 total points.
• On the other hand, the Gamecocks are 2-1 to the over in 2026, including last week’s high-scoring affair against a ranked SEC program (Mississippi State).

Lock in your South Carolina vs. #8 Alabama prediction on PrizePicks now!

South Carolina vs. Alabama Picks, Player Stats for PrizePicks: 9/26/26

Here are the top South Carolina vs. Alabama picks to target on Saturday, September 26. Today’s college football picks for PrizePicks include RB Daniel Hill, WR Lotzeir Brooks, and RB Matt Fuller.

Alabama RB Daniel Hill vs. South Carolina: 73.5 Rush Yards

• Hill has failed to eclipse 60 rushing yards in two of his first three games in 2026.
• RB Trae’shawn Brown has played just 10 fewer run-down snaps (34) and has the same number of rushing TDs (3) as Hill in Alabama’s offense this season.
• South Carolina limited Mississippi State to 4.0 yards per carry in Week 3, and the Bulldogs are fifth in YPC (7.1) to begin the year.

Add Daniel Hill + Alabama to win to your PrizePicks lineup now.

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Alabama WR Lotzeir Brooks vs. South Carolina: 54.5 Rec Yards

• Brooks is coming off a 101-yard performance on 8 catches in Week 3 against Florida State.
• Across the first three weeks, Brooks has the third-most pass-down snaps (80) and second-highest route rate (93.8%) on the Crimson Tide, per PFF.
• Of the five Alabama skill players who have played 65+ pass-down snaps, Brooks has the second-most yards per route run (2.37).

Add Lotzeir Brooks + Alabama to cover the spread to your PrizePicks lineup now.

South Carolina RB Matt Fuller vs. Alabama: 13.5 Rec Yards

• South Carolina found some magic by using Fuller as a pass-catcher more in Week 3, resulting in him catching 7 passes for 85 yards and a score.
• Fuller has logged the third-most pass-down snaps (59) in the Gamecocks’ offense.
• Of the five South Carolina players with 50 or more pass-down snaps, Fuller has the most yards per route run (2.45).

Add Matt Fuller + South Carolina to win to your PrizePicks lineup now.

Make South Carolina vs. Alabama Picks on PrizePicks

South Carolina is trying to avoid a second straight loss, while Alabama aims to take care of business at home to keep its CFP hopes intact. Even with pressure mounting for both programs, points could be a common occurrence in Saturday’s SEC matchup.

Don’t wait until kickoff — make your South Carolina vs. Alabama picks on PrizePicks now and earn real money if you’re right.

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