The college football regular season is almost over, with most teams having only three games left. With the CFB Playoff rankings out, every team understands its chances of a National Championship. This could make it an exciting few weeks.
Below, we'll give you the top Saturday CFB DFS Picks for Week 12 on PrizePicks, including player stats and picks for the premier matchups in the PrizePicks cheat sheet.
There is a huge top 10 matchup in the SEC, with No. 10 Texas taking on No. 5 Georgia. The SEC has another important contest, too, with No. 11 Oklahoma heading to Tuscaloosa to play No. 4 Alabama. The Sooners are barely into the 12-team playoff, and with a 7-2 record, a third loss could take them out of contention. Meanwhile, Alabama wants to stay undefeated in the conference and secure a spot in the SEC Championship.
Below, we'll dig into the projections for the top players in college football, including QBs Julian Sayin and Fernando Mendoza, plus many more QBs, RBs, and WRs to target.
PrizePicks is the simplest way to win real money with your CFB picks. Just pick your players, predict More or Less on their projected stats, and cash in if your picks are correct.
Week 12 Saturday CFB DFS Picks for PrizePicks
Here are the top CFB DFS picks for Week 12, including PrizePicks picks for Texas vs. Georgia and Oklahoma vs. Alabama.
Use this analysis to make your PrizePicks DFS picks for Saturday's games.
Ohio State QB Julian Sayin Projection: 302.5 Passing Yards
UCLA vs. No. 1 Ohio State Pick – 7:30 p.m. ET
- Julian Sayin comes into Week 12 with three straight games of 300+ passing yards.
- Sayin leads the country with an 80.9% completion rate, which is currently an FBS record.
- UCLA is 90th in opponent completion percentage (64.1%).
- The junior ranks second in the FBS with 9.9 yards per completion.
- Ohio State is the No. 1 team in EPA/dropback (0.359), per CFB Graphs.
- The Bruins rank 71st in opposing EPA/dropback (-0.012).
Indiana QB Fernando Mendoza Projection: 238.5 Passing Yards
Wisconsin vs. No. 2 Indiana Pick – 12 p.m. ET
- Wisconsin is 13th in the Big Ten in passing yards allowed per game.
- Mendoza has thrown for fewer than 237 yards in five of his last seven games against Big Ten opponents.
- Of those five games, Mendoza has only faced one opponent that has allowed more passing yards per game than Wisconsin.
- Mendoza threw for 332 yards against Michigan State (15th) and 267 yards against Illinois (16th).
- Wisconsin has allowed more than 265 passing yards in four of its last seven outings.
UConn QB Joe Fagnano Projection: 296.5 Passing Yards
Air Force vs. UConn Pick – 12 p.m. ET
- Fagnano is second in the nation in passing yards (2,840) and passing TDs (25).
- The seventh-year senior has thrown for more than 300 yards in four of his last five games.
- Of the 140 QBs in the FBS who have thrown at least 5 passing TDs, Fagnano is the only one who has not thrown an INT.
- Air Force ranks 134th of 136 FBS programs in passing yards allowed per game (303.5).
- The FBS leader in passing yards is San Jose State QB Walker Eget (2,941). He faced Air Force in Week 11 and threw for 334 yards.
Texas RB Quintrevion Wisner Projection: 43.5 Rushing Yards
No. 10 Texas vs. No. 5 Georgia Pick – 7:30 p.m. ET
- Quintrevion Wisner has fewer than 43 rushing yards in three of his last five games.
- Wisner has rushed for worse than 4.0 yards per carry in two of his last three games.
- Georgia ranks 18th in the nation with 3.3 rushing yards allowed per carry. They're fifth in average yards allowed after contact (2.1).
- The junior's 2.9 average yards after contact ranks 128th among players with a minimum of 80 carries.
- According to Pro Football Focus, the Texas RB has forced 23 missed tackles, ranking 85th.
- Georgia ranks fifth in missed tackle rate (12.0%)
Alabama RB Jam Miller Projection: 55.5 Rush+Rec Yards
No. 11 Oklahoma vs. No. 4 Alabama Pick – 3:30 p.m. ET
- Jam Miller has fewer than 50 combined rushing and receiving yards in three straight games.
- Miller’s 3.6 yards per carry is 29th in the SEC.
- OU is allowing the fewest yards per carry in the country (2.3).
- The senior’s involvement in the offense has diminished in recent weeks. Over his last three games, he’s averaging 12.3 touches per game. He averaged 22 in the three previous games.
- Oklahoma is No. 1 in the country in overall defensive success rate (31.0%), per CFB Graphs.
- The Sooners have the best overall defensive EPA in the SEC, ranking fifth among FBS programs.
Ohio State WR Carnell Tate Projection: 82.5 Receiving Yards
UCLA vs. No. 1 Ohio State Pick – 7:30 p.m. ET
- Carnell Tate has more than 100 receiving yards in four of his last six games.
- Tate is leading the Big Ten with 18.2 yards per catch.
- Ohio State ranks 35th with an average of 4.2 yards after the catch.
- Opponents are gaining 3.9 yards after the catch against UCLA, which ranks 107th.
Make College Football DFS Picks on PrizePicks
With four games between top 25 teams, including a top 10 matchup, Week 12 of college football could reshape the CFB Playoff rankings.
Whether you're watching the SEC matchup between Texas vs. Georgia or Oklahoma vs. Alabama, PrizePicks is the best way to cash in on your college football picks.
Just pick your players — including Julian Sayin and Fernando Mendoza — predict More or Less on their stat projections, and get paid if your picks are correct.
Stay locked in on the Playbook for more CFB DFS picks and college football predictions throughout the 2025 season.
