The Boston Red Sox (4-9) and St. Louis Cardinals (8-5) start Game 2 of their three-game series on Saturday, April 11, at 7:15 p.m. ET, televised by FOX. The Red Sox return a 1.69x payout on PrizePicks Team Picks if they secure a victory.
The Cardinals picked up the 3-2 win on Friday in the first game of the series, so the Red Sox will need this game to tie up the series.
Below, we'll break down our Red Sox vs. Cardinals prediction and picks for Saturday's MLB matchup, including the run line, over/under, and key player picks for PrizePicks.
Make your picks for Red Sox vs. Cardinals on PrizePicks now.
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Red Sox vs. Cardinals Prediction, Winner Payout, Over/Under – Saturday, April 11
For the second game of this series, Red Sox SP Ranger Suarez, who has a 4.23 xFIP across two starts and 8.1 innings pitched in 2026, will battle with Cardinals SP Kyle Leahy, who touts a 4.90 xFIP across two starts and 10.0 innings pitched.
Suarez was one of Boston’s biggest signings in the offseason, and it’s been a disaster so far. After a stellar 2025 season with the Phillies, during which his 31.1% hard-hit rate ranked in the 98th percentile via Baseball Savant, that number has ballooned to 46.7%, putting him in the 25th percentile.
The Red Sox bats have not helped, ranking 18th in wOBA (.306) and 25th in xSLG (.354), per FanGraphs.
For the Cardinals, Leahy spent the first three years of his career as a reliever, with only one start in 98 appearances. The transition to the rotation has been rough; his 7.20 xERA is in the ninth percentile, while he’s seen a drop in fastball velocity, going from 95.4 last season to 93.7 this year.
The Cardinals’ bats are showing their power early in the season, ranking fifth with a .410 xSLG, paired with 13 home runs (fifth).
Red Sox vs. Cardinals Winner Payout, Over/Under – Saturday, April 11
The Red Sox enter Saturday’s game as road favorites, returning a 1.69x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Red Sox vs. Cardinals game on PrizePicks.
- Spread: Red Sox -1.5 (2.17x payout)
- Over/Under: 7.5 (1.81x payout on Over)
- Game Winner Payout: Red Sox 1.69x | Cardinals 2.08x
Play the Red Sox vs. Cardinals winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!
Team Picks data is live at the time of writing and is subject to change.
Red Sox vs. Cardinals Prediction on Over/Under – 4/11/26
Here are the key game stats and trends behind our Red Sox vs. Cardinals prediction on the run total for Saturday, April 11.
Lock in your Red Sox vs. Cardinals prediction on PrizePicks before the line moves.
- The Cardinals are showing discipline early in the season, with their 27.8% chase rate ranking eighth, per Baseball Savant.
- In comparison, the Red Sox are a step behind in chasing bad pitches, with their 30.7% chase rate (seventh).
- Boston also produces a lot of swing and misses, as their 31.5% whiff rate is the second-worst mark in MLB.
- Allowing a .450 xSLG (27th), the Sox's pitching could struggle against St. Louis’ power.
- The Red Sox are only 1-6 on the road this season.
Red Sox vs. Cardinals Player Picks, Stats for PrizePicks – 4/11/26
Here are the top Red Sox vs. Cardinals picks to target on PrizePicks for Saturday, April 11. Today’s MLB picks for PrizePicks include Jordan Walker and Wilyer Abreu.
Cardinals OF Jordan Walker vs. Red Sox Projection: 4.5 Hitter Fantasy Score
- Walker's hitter fantasy score has surpassed 4 points in five straight games
- The four-year veteran is red-hot with a hit in five consecutive games, recording an RBI in three straight.
- Walker's enjoyed a breakout season with elite numbers, including his 26.7% barrel rate (99th percentile).
- The Red Sox's pitching struggles to keep the ball off the sweet spot of their opponents’ bats, ranking 28th with an 11.8% barrel rate allowed.
- The 2020 21st overall pick crushes the ball with his 70.0% hard-hit rate, ranking second in MLB.
Add Jordan Walker to your PrizePicks Lineup now.
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Red Sox OF Wilyer Abreu vs. Cardinals Projection: 5 Hitter Fantasy Score
- The Boston outfielder has reached at least a 5-point hitter fantasy score in four consecutive appearances.
- Abreu is a bright spot on a struggling Boston offense, with his .294 xBA ranking in the 87th percentile.
- The Cardinals sit last in MLB with opponents posting a .283 xBA.
- The Venezuelan native hits better away from Fenway Park with a .585 wOBA compared to .395 at home.
- Leahy has struggled against left-handed batters, with a .422 wOBA compared to .227 vs. righties.
Add Wilyer Abreu to your PrizePicks Lineup now.
Make Red Sox vs. Cardinals Picks on PrizePicks
The Red Sox haven't grabbed a road win since Opening Day. Will Boston snap that brutal streak against the Cardinals on Saturday night?
Don’t wait until the first pitch — make your Red Sox vs. Cardinals picks on PrizePicks now and earn real money if you’re right.
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