Two Super Bowl contenders will take center stage on Sunday Night Football when the Denver Broncos host the Los Angeles Rams at 8:20 p.m. ET on NBC. The Rams enter the game as a 1.5-point favorite with a 1.72x payout if they win, via PrizePicks.
The Rams fell to the San Francisco 49ers in Week 1 in the NFL’s Australia game but rebounded with a convincing 28-6 win over the New York Giants in Week 2. Meanwhile, the Broncos also rebounded from a Week 1 loss, a 31-10 defeat to the Kansas City Chiefs, and topped the Jacksonville Jaguars 20-13 in Week 2.
Below, we'll break down our Rams vs. Broncos prediction and picks for Sunday Night Football, including the spread, over/under, and top player picks for PrizePicks.
Make your Rams vs. Broncos picks on PrizePicks now!
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Rams vs. Broncos Prediction, Spread, Over/Under for Sunday Night Football
The Rams reached the NFC Championship Game last season but ultimately fell short against the Seattle Seahawks. Entering the 2026 campaign, Los Angeles acquired star CB Trent McDuffie in an offseason trade with the Chiefs and convinced DT Aaron Donald to come out of retirement, paired with a blockbuster trade for EDGE Myles Garrett — though he's on injured reserve.
Expectations are certainly lofty for the Rams, so a season-opening loss to the 49ers was concerning. However, the Rams put together a statement win against the Giants this past Monday while being without star WR Puka Nacua.
Los Angeles QB Matthew Stafford was incredibly efficient, completing 22 of 31 passes for 327 yards and 4 TDs against New York. Without Nacua, Stafford leaned on WR Davante Adams (195 yards & 2 TDs) and TE Terrance Ferguson (54 yards & a TD) to lead the Rams’ passing attack.
The Rams will likely be without Nacua once again in Week 3 as he continues to deal with a hip injury. Nacua is listed as doubtful for Sunday night’s contest, and Rams head coach Sean McVay admitted earlier this week that the star WR wasn’t making “great progress.”
Meanwhile, the Broncos made it to the AFC Championship Game last season but lost to the New England Patriots after QB Bo Nix was sidelined with a fractured ankle in the previous round.
The Broncos were shut down by the Chiefs’ defense in Week 1, and RB Kenneth Walker III ran all over Denver’s defense. However, Denver bounced back with a hard-fought win over Jacksonville in Week 2.
Nix completed 22 of 31 passes for 288 yards and 1 TD, while also tossing an INT against the Jaguars. After registering just 1 reception for 2 yards in Week 1, Broncos WR Jaylen Waddle had a sensational game, hauling in 8 passes for 138 yards on 10 targets.
Denver will be without rookie RB Jonah Coleman, who was placed on injured reserve due to an ankle injury. The Broncos will also remain without OLB Jonathon Cooper, who is on the commissioner’s exempt list due to a pending domestic violence case.
Rams vs. Broncos Spread, Over/Under – Sunday, September 27
The Rams enter Sunday night's game as 1.5-point favorites against the Broncos, via PrizePicks, returning a 1.72x payout with an outright win.
Here are the full payouts for Rams vs. Broncos on PrizePicks.
Make your Rams vs. Broncos prediction on the over/under on PrizePicks.
PrizePicks data is live at the time of writing and is subject to change.
Rams vs. Broncos Prediction on Over/Under for Sunday Night Football – 9/27/26
Here are the key stats and predictions behind our Rams vs. Broncos prediction on the over/under for Sunday Night Football.
- The under is 2-0 in the Rams’ first two games, while the under also has a 2-0 mark in the Broncos’ opening two contests.
- The Rams have allowed 16.5 points per game and have held their opponents to just 167.5 passing yards per contest in two games this season.
- Los Angeles has also allowed a -0.19 EPA/pass in 2026 (seventh), per SumerSports.
- Meanwhile, the Broncos have gotten off to a slow start offensively, averaging just 201.5 passing yards per contest (20th). Denver also posted a -0.16 EPA/pass (26th).
- QB Bo Nix has registered just a 6.68 average depth of target in two games (31st among QBs).
- Denver has tallied a -0.18 EPA/rush (26th), averaging just 3.8 yards per carry (19th).
Lock in your Rams vs. Broncos prediction on PrizePicks before Sunday Night Football.
Rams vs. Broncos Picks, Player Stats for SNF on PrizePicks: 9/27/26
Here are the top Rams vs. Broncos picks to target on Sunday, September 27, on PrizePicks. Top SNF player picks include WR Davante Adams and QB Bo Nix.
Rams RB Blake Corum vs. Broncos: 47.5 Rush Yards
- Corum has been entrenched in a 50/50 timeshare with RB Kyren Williams in the Rams’ backfield and carried the ball 22 times for 133 yards (6.0 yards per carry) against the Giants in Week 2.
- According to PlayerProfiler, Corum has averaged 66.5 rushing yards per game, which ranks 14th among NFL RBs.
- The Broncos’ defense has recorded 0.19 EPA/rush allowed over two games (30th).
- Corum has tallied a 30.4% juke rate, ranking 10th among RBs.
Pick Blake Corum + Rams to win on PrizePicks!
Rams WR Davante Adams vs. Broncos: 70.5 Receiving Yards
- Adams caught 8 passes for 195 yards and 2 TDs on 10 targets against the Giants in Week 2.
- With teammate Puka Nacua missing time, Adams has tallied a 28.1% target share (seventh among WRs).
- Adams has registered an average target distance of 16.9 yards, sitting 11th among NFL WRs.
- The Broncos’ defense features -0.18 EPA/pass allowed in two games (10th), but the unit still allowed Jaguars top WR Parker Washington to catch 7 passes for 98 yards in Week 2.
Pick Davante Adams + Rams to win on PrizePicks!
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Broncos QB Bo Nix vs. Rams: 211.5 Pass Yards
- Nix has completed 64.9% of his passes for 419 yards and 2 TDs but was limited to just 131 passing yards against the Chiefs in Week 1.
- Ranking 27th among QBs, Nix has tallied just 6.1 air yards per passing attempt. That gets even worse with his 5 deep ball attempts over two contests (20th).
- The Rams’ defense has posted -0.19 EPA/pass allowed, ranking seventh in the league.
Pick Bo Nix + Broncos to win on PrizePicks!
Make Rams vs. Broncos Picks on PrizePicks
The Broncos and Rams are off to 1-1 starts but are still viewed as Super Bowl contenders in 2026. Points could be at a premium in Sunday’s primetime affair.
Don't wait until kickoff — make your Rams vs. Broncos picks on PrizePicks Team Picks. There is a wide variety of player stat projections on the NFL board, so you can make predictions on yards, touchdowns, and more! Just pick your players, predict More or Less on their stats, and cash in on your predictions if you're right.
With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available on PrizePicks.
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