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PrizePicks MLB Cheat Sheet Today: Top MLB DFS Picks – 5/21/25

Red Sox DH Rafael Devers reacts after hitting a walkoff home run. Devers is a top MLB DFS pick in the PrizePicks MLB Cheat Sheet today, for May 21, 2025.

The Wednesday MLB slate showcases a full slate of 15 games, including several key night matchups. Headlining the MLB DFS slate, the Yankees and Rangers hook up in the Bronx at 7:05 p.m. ET, while the Dodgers and Diamondbacks meet in Los Angeles at 10:10 p.m. ET.

Welcome to Wednesday’s MLB DFS Picks, as we’ll break down today’s MLB games and give you the best MLB DFS picks for PrizePicks for May 21, including pitcher strikeout projections, hitter projections, and a home run pick to target today.

Let’s break down some of the best MLB picks to target for the Wednesday MLB DFS slate on PrizePicks.

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MLB DFS Picks on PrizePicks: Wednesday, 5/21

Here are some of the top MLB DFS picks and predictions on PrizePicks today. Use this analysis to help you build a stacked MLB Lineup on PrizePicks for Wednesday, May 21. Click each pick to read more.

Rangers P Jacob deGrom — 6.5 Strikeouts

  • Rangers P Jacob deGrom has compiled seven strikeouts or more in four of his last six starts.
  • deGrom struck out seven batters in his previous start against Houston, while tossing eight innings, marking his longest outing of the season.
  • In 16 of New York’s last 18 home games, starting pitchers facing the Yankees have finished with less than their strikeout projection on PrizePicks.
  • The two Yankees that have struggled the most against deGrom are LF Cody Bellinger and 2B D.J. LeMahieu. Bellinger has struck out seven times in 16 at-bats, while LeMahieu has struck out eight times in 19 at-bats.
  • New York’s offense has struck out six or fewer times against opposing starting pitchers in each of the last 10 games.

Blue Jays P Kevin Gausman — 4.5 Strikeouts

  • Blue Jays P Kevin Gausman has not eclipsed his strikeout projection in consecutive starts this season.
  • Gausman posted six strikeouts against Tampa Bay in his last trip to the mound, his fourth outing of at least six strikeouts this season.
  • Opposing right-handed starting pitchers finished with less than their strikeout projection in San Diego’s last five road games prior to Tuesday night. Toronto’s Chris Bassitt put up six strikeouts in last night’s 3-0 win.
  • In 26 at-bats against Padres RF Fernando Tatis, Jr. and 1B Luis Arraez, Gausman has compiled one strikeout.

Angels LF Taylor Ward — 1.5 Total Bases

  • Angels LF Taylor Ward is riding a six-game hitting streak heading into Wednesday. 
  • Ward picked up a pair of doubles in Tuesday’s 7-5 victory over the Athletics.
  • Since May 11, Ward has compiled four multi-hit games, while six of his eight games with at least two hits this season have come on the road.
  • Sears has not fared well under the lights this season, owning a 4.68 ERA in night action compared to a 1.88 ERA in day contests.
  • Ward has struggled against Athletics P J.P. Sears, picking up only one hit in nine at-bats.

Home Run Pick: Red Sox DH Rafael Devers

  • Red Sox DH Rafael Devers has hit 10 home runs this season, including five in May.
  • Nine of Devers’ 10 home runs have come against right-handed pitchers as he faces New York’s Tylor Megill tonight.
  • Devers went deep in Tuesday’s 2-0 victory over the Mets, marking his third homer in the last four games.
  • Mets pitcher Trevor Megill has been torched recently, allowing 12 runs in the last three starts, including two home runs.
  • The forecast in Boston calls for 11 MPH winds blowing towards left field today.

Note: Demon picks increase your payout on PrizePicks, as they are harder projections to hit.

Make MLB DFS Picks, Win Cash on PrizePicks

There’s exciting action on Wednesday’s MLB slate as every team takes the diamond from early in the day through the night. With 15 MLB games on tap, now is time to build your MLB Lineup on PrizePicks.

Just pick More or Less at least two MLB player stat projections to build your Lineup on PrizePicks. Use the players above to build your Lineups around, or use a 6-Pick Lineup to reach up to 2000x payouts. New to PrizePicks? Claim your $50 bonus when you sign up here.

Check out the Playbook for more MLB DFS picks and analysis all the way through the season.

about the author

Kevin has spent the last 15 years in the sports gambling space. He covered all major sports at VegasInsider both as a writer and handicapper from 2009 until 2024. He has also covered college basketball and MLB for the Action Network.

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