The Pittsburgh Pirates vs. Chicago Cubs is set for a first pitch at 2:20 p.m. ET on Saturday, April 11, with Chicago featuring a 1.63x payout to win, via PrizePicks.
Pittsburgh captured the series opener at Wrigley Field on Friday afternoon, 2-0. The Pirates were no-hit through six innings but broke through with a 2-run blast from LF Bryan Reynolds for the only runs of the game.
Below, we'll break down our Pirates vs. Cubs prediction and picks for Saturday's MLB game, including the winner, over/under, and key player picks for PrizePicks.
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Pirates vs. Cubs Prediction, Winner Payout, Over/Under – Saturday, April 11
The Pirates have won seven of their last nine games since a 1-3 start, including three consecutive road victories.
Chicago was held to fewer than 1 run for the fourth time this season, although the pitching staff limited its opponent to 2 runs for the third straight game.
The Cubs captured 10 of 13 matchups from the Pirates last season. In Pittsburgh’s last four wins over Chicago, the Pirates never scored more than 4 runs. The Pirates have plated 3 or fewer runs in 11 of the past 14 meetings.
Chicago owns a 5-1 record off a loss, averaging 6.1 runs per game in those outings.
Pirates vs. Cubs Winner, Over/Under – Saturday, April 11
The Cubs enter Saturday’s game as a home favorite against the Pirates, returning a 1.63x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Pirates vs. Cubs game on PrizePicks.
- Spread: Cubs -1.5 (2.5x payout)
- Over/Under: 6.5 (1.81x payout on Over)
- Game Winner Payout: Pirates 2.12x | Cubs 1.63x
Play the Pirates vs. Cubs winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!
Team Picks data is live at the time of writing and is subject to change.
Pirates vs. Cubs Prediction on Winner – 4/11/26
Here are the key game stats and trends behind our Pirates vs. Cubs prediction for the winner on Saturday, April 11.
Lock in your Pirates vs. Cubs prediction on PrizePicks before the line moves.
- Cubs SP Edward Cabrera has yielded a .151 xBA and .242 xSLG through two starts, both career bests.
- Friday marked the first time in five games that Pittsburgh won despite being held scoreless through the five innings.
- The Pirates are averaging 5.4 strikeouts per game against opposing right-handed starting pitchers.
- Chicago’s offense is producing a hard-hit rate of 45.3%, the second-highest in MLB.
- Pittsburgh SP Braxton Ashcraft owns a 38.7% hard hit rate allowed, and the top 10 pitchers in this category sit at 30.0% or lower.
- The Cubs are 4-0 as a favorite off a loss this season.
Pirates vs. Cubs Player Picks, Stats for PrizePicks – 4/11/26
Here are top Pirates vs. Cubs picks to target on PrizePicks for Saturday, April 11. Today’s MLB picks for PrizePicks include 2B Nico Hoerner and SP Braxton Ashcraft.
Cubs 2B Nico Hoerner vs. Pirates Projection: 6.5 Hitter Fantasy Score
- Hoerner had several huge fantasy scores against the Rays, racking up 17 points on Tuesday and 26 points on Wednesday.
- He finished with a single in 4 at-bats in Friday’s loss but extended his hitting streak to five games.
- In eight of 13 games, Hoerner closed with at least 7 fantasy points.
- He owns an excellent xBA of .322, ranking in the 95th percentile in MLB.
- His xwOBA of .387 sits in the 86th percentile, surpassing his .322 average from last season.
Add Nico Hoerner to your PrizePicks Lineup now.
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Pirates SP Braxton Ashcraft vs. Cubs Projection: 5 Strikeouts
- In two starts against Chicago last season, the right-hander finished with 4 strikeouts apiece.
- He is coming off an 8-strikeout performance against Baltimore, marking his second straight start of 6 innings.
- Ashcraft relies on his curveball for his success, as opponents are 0 for 10 with 6 Ks against that pitch this season.
- Cubs 3B Alex Bregman has a 33.0% K rate against curves, while LF Ian Happ has struck out in all 4 at-bats closing with a curveball.
Add Braxton Ashcraft to your PrizePicks Lineup now.
Make Pirates vs. Cubs Picks on PrizePicks
The Cubs have done a solid job of bouncing back from a loss, and they come off Friday's 2-0 shutout by the Pirates. Pittsburgh is moving in the right direction, but will the Pirates pull off another victory at Wrigley Field?
Don’t wait until lock — make your Pirates vs. Cubs picks on PrizePicks now and earn real money if you’re right.
Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.
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