The Pittsburgh Pirates (16-11) and Milwaukee Brewers (13-13) will meet in the finale of their three-game series on Sunday, April 26, at 2:10 p.m. ET, with the Pirates favored by the 1.5 run line.
The Pirates have taken both games and are looking for a road sweep in Milwaukee.
Below, we'll break down our Pirates vs. Brewers prediction and picks for Sunday’s MLB matchup, including the run line, over/under, and key player picks for PrizePicks.
Make your picks for Pirates vs. Brewers on PrizePicks now.
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Pirates vs. Brewers Prediction, Winner Payout, Over/Under – Sunday, April 26
Pittsburgh is 6-4 over the last 10 games and 3-1 in its previous four matchups. Meanwhile, Milwaukee is sliding on a four-game losing streak, taking its record to 5-5 over the last 10 games.
Pirates SP Carmen Mlodzinski (3.46 xFIP in 5 games, 4 starts, and 24.2 IP) and Brewers SP Kyle Harrison (4.24 xFIP in 4 starts and 17.2 IP) will square off on the mound.
Pirates vs. Brewers Winner Payout, Over/Under – Sunday, April 26
The Pirates enter Sunday’s game favored by 1.5 on the run line.
Here's a look at the spread and run total for the Pirates vs. Brewers on Sunday.
- Spread: Pirates -1.5
- Over/Under: 7.5
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Team Picks data is live at the time of writing and is subject to change.
Pirates vs. Brewers Prediction on Over/Under – 4/26/26
Here are the key game stats and trends behind our Pirates vs. Brewers prediction on the run total for Sunday, April 26.
Lock in your Pirates vs. Brewers prediction on PrizePicks before the line moves.
- These are two of the best offenses in the league, ranking in the top nine in runs per game.
- The Brewers' pitching has plummeted recently, allowing 22 runs over their last four games.
- Ranking 11th in hard-hit rate (41.0%), the Pirates have established themselves as a power-hitting lineup.
- The total has gone over in two of Harrison’s last three appearances.
- The Pirates have the seventh-highest over rate against National League Central opponents (62.5%).
Pirates vs. Brewers Player Picks, Stats for PrizePicks – 4/26/26
Here are the top Pirates vs. Brewers picks to target on PrizePicks for Sunday, April 26. Today’s MLB picks for PrizePicks include William Contreras and Kyle Harrison.
Brewers C William Contreras vs. Pirates Projection: 1.5 Hits+Runs+RBIs
- The catcher for the World Baseball Classic champion, Team Venezuela, has exceeded this projection in three of his last five games.
- Contreras has enjoyed success against Mlodzinski, with a .364 lifetime xBA.
- It is difficult to get the former Brave to swing and miss, as his 17.6% whiff rate is in the 84th percentile, per Baseball Savant.
- Mlodzinski struggles to generate swings and misses, with a 20% whiff rate that sits in the 16th percentile.
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Brewers SP Kyle Harrison vs. Pirates Projection: 1.5 Walks Allowed
- Harrison has walked fewer than two batters in two of four starts this season.
- In 16 career plate appearances, the Pirates have 0 walks against Harrison.
- Pittsburgh struggles to generate bases on balls away from PNC Park, as their 3.2 walks per game on the road rank 22nd.
- If Harrison throws it out of the strike zone, the Pirates will likely swing at it with their 31.1% chase rate (26th).
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The Pirates would love to pull out the brooms on their division rivals as they go for the sweep against the reigning NL Central champions. Will the Brewers find a way to snap their losing streak on Sunday?
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