Pirates vs. Athletics Prediction, MLB Picks for Tuesday, June 16

Today's Pirates vs. Athletics game is set for first pitch at 9:40 p.m. ET on Tuesday, June 16, with the Athletics the favorites, having a 1.69x payout if they win, via PrizePicks.

Neither team will have impressive starting pitchers on the mound in the late-night showdown. The Pirates will turn to SP Mitch Keller (5-4, 5.14 ERA), who hasn’t finished a season with an ERA below 4.20 since 2022. The Athletics will counter with Jack Perkins (2-3, 6.25 ERA), who has unsuccessfully moved into a starting role, giving up 8 runs in his last two starts.

Below, we’ll break down our Pirates vs. Athletics prediction and picks for Tuesday’s MLB game, including game winner, over/under, and key player picks for PrizePicks.

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Pirates vs. Athletics Prediction, Winner Payout, Over/Under – Tuesday, June 16

The Athletics dominated Monday’s 11-2 victory vs. the Pirates. They scored 5 runs off Pirates SP Jared Jones, hitting 2 home runs along the way — led by budding superstar Nick Kurtz, who now has 8 HRs and 16 RBIs in June. The A's are now tied for the fifth-most home runs (95) in baseball.

On the other hand, the Pirates don’t have the same type of power, which has left them tied for 12th (86) in homers. Right now, they are missing one of their best power hitters in OF Oneil Cruz, who is second on the team in home runs (14) and will be out for 4-to-6 weeks with a hand injury.

With their loss Monday, the Pirates fell to 16-18 on the road. They are 2-8 across their last 10 games. The Athletics are 6-4 over their last 10 games, despite still having a losing record at home (16-19) — which may be a reason they're the favorites today.

Pirates vs. Athletics Winner Payout, Over/Under – Tuesday, June 16

The Athletics enter Tuesday’s game as a home favorite against the Pirates, returning a 1.69x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Pirates vs. Athletics game on PrizePicks Team Picks — where you can make real money predictions on every MLB game!

• Spread: Athletics -1.5 (2.32x payout)
• Over/Under: 10.5 runs (1.78x payout Over)
• Game Winner Payout: Athletics 1.69x | Pirates 2.04x
• Team Picks data is live as of publishing and is subject to change.

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Pirates vs. Athletics Prediction on Over/Under – Tuesday, June 16

Here are the key game stats and trends behind our Pirates vs. Athletics prediction on the over/under for Tuesday, June 16.

• The Athletics have the highest home OPS (.829) in baseball. The team with the next-highest mark is the Yankees at .801.
• Keller allowed 5 runs over 4 innings against the Dodgers in his last start. That was his third straight outing in which he gave up at least 5 runs.
• The A's have hit 55 of their 95 home runs at home, partly thanks to the positive ballpark environment.
• The Athletics have third-highest wRC+ in baseball over the last two weeks (136), partly aided by their series in elevation in a minor league park in Vegas last week. The Pirates are 15th (108).
• Even with Cruz out right now, the Pirates aren’t a pushover at the plate. They have scored the fourth-most runs and have the seventh-highest OPS in baseball.
• The Pirates have the second-highest OPS in the majors (.757) versus right-handed pitchers.

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Pirates vs. Athletics Player Picks, Stats for PrizePicks – 6/16/26

Here are top Pirates vs. Athletics picks to target on PrizePicks for Tuesday, June 16. Today's MLB picks for PrizePicks include Athletics 1B Nick Kurtz and Pirates 1B Spencer Horwitz.

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Athletics 1B Nick Kurtz vs. Pirates Projection: 1.5 Total Bases

• Nick Kurtz went 3-for-4 with 2 HR and 5 RBIs in Monday’s lopsided victory.
• The slugging first baseman has 7 home runs across his last 8 games. That has increased his ISO to .270 for the season.
• Per Fangraphs, Kurtz has a .476 wOBA and a .350 ISO at home.
• Although Keller has only allowed 6 home runs this season, 5 of them were launched by left-handed hitters. He has limited righties to a .271 wOBA, but lefties have a .339 wOBA against him.

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Pirates 1B Spencer Horwitz vs. Athletics Projection: 5.5 Hitter Fantasy Score

• While not a flashy option, Horwitz has boosted the Pirates’ lineup with his .369 wOBA and .172 ISO. Those are both on pace to be the highest marks of his career.
• The former Blue Jay continues to show a good eye at the plate, posting a 13.3% walk rate to go with his 14.0% strikeout rate.
• For his career, Horwitz has a .364 wOBA and a .184 ISO against right-handed pitchers.
• Perkins has a 1.47 WHIP over his last six appearances. Behind him is an A’s bullpen that has a 1.41 WHIP for the season.

Add Spencer Horwitz to your PrizePicks MLB Lineup now!

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Make Your Pirates vs. Athletics Prediction on PrizePicks

Two underwhelming starting pitchers in a hitter-friendly environment could lead to a high scoring game between the Athletics and Pirates tonight.

Kurtz comes to the plate on an absolute heater, with plenty of power upside, while Horwitz has the potential to also shine for the Pirates.

Don’t wait until the first pitch — make your Pirates vs. Athletics picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

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