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Padres vs. Mariners Prediction, Picks, 8/27/25: Look to Bryan Woo, J-Rod

Mariners SP Bryan Woo takes the mound vs. the Padres in an afternoon game in Seattle today.
AP Photo/Yuki Iwamura

The Padres and Mariners have split the first two games of their three-game series that concludes Wednesday, August 27 at 4:10 p.m. ET on MLB Network.

This afternoon game sets up a great pitching matchup between veteran Padres SP Yu Darvish (3-3, 4.25 xFIP) facing Mariners SP Bryan Woo (11-7, 3.49 xFIP), a 25-year-old who has quickly become one of the league's best arms.

Below, we'll get into our Padres vs. Mariners prediction and picks for MLB DFS on PrizePicks, including Woo and Julio Rodriguez.

Whether you want to attack home runs, hits, or pitcher strikeouts, Padres vs. Mariners provides plenty of opportunitiesto make MLB predictions on PrizePicks. Let’s highlight some picks to help you build your Lineups for Wednesday’s MLB DFS slate.

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Padres vs. Mariners Prediction, Preview for Wednesday, August 27

The Padres (75-58) and Mariners (71-62) are both in the thick of the playoff hunt. The Mariners are 1.5 games back of the Astros in the AL West and currently hold the third Wild Card spot in the American League. The Padres are one game back of the Padres in the NL West and are sitting in the second Wild Card spot in the National League.

This game being in Seattle is noteworthy. While the Mariners are only 31-35 on the road this season, they are 40-27 at home. The Padres have a sparkling home record of 43-22, but they are 32-36 on the road.

Padres

The Padres used five relievers in their win over the Mariners on Tuesday. However, their bullpen should be in good shape for Wednesday. Mason Miller has pitched one time over the last four days, while Robert Suarez, Jason Adam, and Adrian Morejon have all pitched one time over the last three days. The Padres have the best bullpen ERA (3.04) and WHIP (1.15) in baseball.

Mariners

The Mariners have struggled down the stretch, going 3-7 over their last 10 games. Even with their additions of 3B Eugenio Suarez and 1B Josh Naylor at the trade deadline, they only have a .713 OPS over the last 30 days.


Padres vs. Mariners Picks, Projections – Wednesday, August 27

Here are the top Padres vs. Mariners picks for Wednesday, August 27. Find these player projections on the PrizePicks MLB board, and pick More or Less on player stats to win real money.

Mariners SP Bryan Woo vs. Padres Projection: 5 Strikeouts

  • Woo has logged at least six innings in all 25 of his starts this season.
  • With Woo pitching so deep into games, he has recorded at least 6 strikeouts in 18 of his starts.
  • That includes him reaching at least 6 strikeouts in each of his last seven starts.
  • The Mariners’ righty has a 13.0% swinging strike rate that puts him in the 78th percentile in baseball.
  • He has a 26.7% strikeout rate at home, compared to 24.9% on the road.

Mariners OF Julio Rodriguez vs. Padres Projection: 1.5 Hits+Runs+RBI

  • Rodriguez is 3-for-8 with 2 runs scored over the first two games of this season.
  • The slugger has caught fire down the stretch, hitting 21-for-63 (.333) with 4 home runs, 11 RBI, and 11 runs scored over his last 16 games.
  • Rodriguez hits the ball hard, generating an average exit velocity of 91.5 mph that is in the 85th percentile in the league.
  • Darvish doesn’t miss many bats, posting just a 22.0% strikeout rate this year. He also has a 1.34 WHIP on the road.

Padres 1B Luis Arraez vs. Mariners Projection: 5.5 Hitter Fantasy Score

  • Woo has only allowed 120 hits across 159 innings this season.
  • Woo has a career 0.99 WHIP.
  • Of Arraez’s 147 hits this season, only 39 of them have gone for extra bases. That includes just 6 home runs.
  • Across his last 15 games, the Padres’ first baseman is 12-for-62 (.194) with 4 RBI and 1 run scored.

Make MLB Picks on PrizePicks

The Mariners and Padres will try to improve their playoff positioning when they face off Wednesday. Runs might be difficult to come by with Woo facing off against Darvish. This matchup leaves plenty of projections to consider on PrizePicks to win money on MLB.

Just build your MLB Lineup on PrizePicks with your favorite MLB players and win real money if your picks are correct. All you have to do is pick More or Less on at least two player projections — like hits or pitcher strikeouts — to win.

Stay locked in on the Playbook all season long for MLB player picks every day.

Get in the game! Sign up for PrizePicks and cash in on your sports predictions. Play $5 and get $50 instantly in Lineups with promo code PLAYBOOK.

about the author

Mike Barner has been covering fantasy sports since 2007. He specializes in the NBA, NFL, and MLB. He is a two-time finalist for the Fantasy Sports Writers Association Basketball Writer of the Year award and won the 2021-22 FSGA NBA Experts Champions league. In addition to PrizePicks, Mike has written for Sports Illustrated, RotoWire, SportsLine, and more.

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