Padres vs. Giants Prediction, MLB Picks for Sunday Night Baseball – 9/13/26

Sunday Night Baseball marches on with two weeks remaining in the 2026 MLB regular season. The San Diego Padres (80-68) and San Francisco Giants (62-87) collide in an NL West rivalry at 7:20 p.m. ET on Sunday, September 13.

Tonight’s primetime game moves over to Peacock, with the Cowboys vs. Giants kicking off Sunday Night Football on NBC. That doesn’t take away from tonight’s stakes, though, as the Padres currently hold the last Wild Card spot in the National League. 

Against a Giants team with the fourth-worst record in baseball, PrizePicks tabs San Diego as the favorite with a 1.72x payout to win tonight. Let’s break down the Sunday Night Baseball matchups, providing our Padres vs. Giants prediction and picks for PrizePicks.

Make your Padres vs. Giants picks for Sunday Night Baseball on PrizePicks now!

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Padres vs. Giants Prediction, Winner, Over/Under – Sunday, September 13

The Padres have gotten hot at the perfect time, as their 7-3 record in the last 10 games gives them a 1.5-game lead for the final Wild Card spot in the National League.

The Diamondbacks are the only threat to remove San Diego from a playoff spot, as all other NL teams behind Arizona in the standings have been eliminated from postseason contention. With a 5-2 record in their last seven games, the D-backs continue to apply the pressure on San Diego.

Following back-to-back wins, the Padres are chasing a sweep of the Giants on Sunday Night Baseball. San Diego gave up 5.5 runs per game in the first two matchups, but its 7.0 runs per contest were enough to fuel wins.

For Sunday night, Padres SP Nick Pivetta (3.43 ERA, 2.43 xERA in 5 GS) will make his sixth start of the season. In a down year, Giants SP Logan Webb (4.10 ERA, 4.09 xERA in 27 GS) will get the start under the lights.

Padres vs. Giants Winner Payout, Over/Under – Sunday, September 13

The Padres will be favored for their eighth straight game tonight, featuring a 1.72x payout to win tonight. 

Here are the full payouts for the Padres vs. Giants game on PrizePicks, including winner payouts, the spread, and over/under.

Make your Padres vs. Giants prediction on the winner on PrizePicks.

PrizePicks data is live at the time of writing and is subject to change.

Padres vs. Giants Prediction on Winner for Sunday Night Baseball – 9/13/26

Following four starts to open the season, Padres SP Nick Pivetta missed almost five months due to an elbow injury, finally making his return on September 7.

Despite his long absence, Pivetta was given a pretty long leash in his first start back, totaling 5.0 innings pitched. His excellent outing with 2 hits and 0 earned runs allowed helped his case — though his 5.65 xERA in the start suggests regression, per FanGraphs.

Still, this is a major addition to the rotation, with Pivetta posting a 2.87 ERA over 31 starts in the 2025 season. Further, the veteran hurler had 2.92, 1.71, and 1.44 xFIPs in three starts from April 1 to April 12.

Meanwhile, Giants SP Logan Webb has been lit up to the tune of a 9.18 ERA over his previous four starts. In that split, San Francisco is 1-3 outright — adding to its 10-16 record when Webb is on the bump this season.

After posting 3.03, 2.90, 3.25, 3.47, and 3.22 ERAs over his last five seasons, this has been a season to forget for Webb, touting a 4.10 ERA and a 3.77 xFIP that would be his lowest mark since 2020.

San Diego has the lowest bullpen xERA (3.18) this season, compared to San Francisco’s 4.15 xERA (19th). Further backed by 7.7 runs per game over the last three matchups, the Padres could add to their playoff hopes on Sunday Night Baseball.

Lock in your Padres vs. Giants prediction on PrizePicks before the first pitch.

Padres vs. Giants Picks, Player Stats for PrizePicks – 9/13/26

Here are top Padres vs. Giants picks to target on PrizePicks for Sunday, September 13. Tonight’s MLB picks for PrizePicks include Jackson Merrill and Jung Hoo Lee.

Padres OF Jackson Merrill vs. Giants: 5.5 Hitter Fantasy Score

• Jackson Merill has been Logan Webb’s worst nightmare, sporting a ridiculous .611/.632/.778 slash line over 18 at-bats in head-to-head battles, per Sports Reference.
• Webb started on May 5 vs. the Padres, and Merrill proceeded to total 3 hits, 1 double, and 2 RBIs over 5 at-bats in that game.
• San Diego’s center fielder bats .406 against sinkers, and Webb’s sinker is his most-used pitch with a 29.3% usage rate, via Baseball Savant.
• After allowing 1 home run in three of his last four starts, Webb may be in trouble against Merrill’s .490 xSLG (91st percentile), 12.8% barrel rate (85th percentile), and 48.3% hard-hit rate (88th percentile).
• Adding to the exceptional head-to-head matchup, Merrill is batting .342 in September, including 8 hits over his previous 14 at-bats (.571).

Add Jackson Merrill to your PrizePicks lineup now.

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Giants OF Jung Hoo Lee vs. Padres: 0.5 Singles

• Jung Hoo Lee rakes against Nick Pivetta, with a .462/.500/1.077 slash line over 13 at-bats. 
• San Francisco’s outfielder has an alarming .158 batting average in September, but he’s tallied 3 hits over his last three games.
• Pivetta has an elite 31.3% strikeout rate this season, but Lee barely strikes out, with a 10.0% K rate (97th percentile) and 12.5% whiff rate (97th percentile).
• Lee’s chances of getting on base are further supported by his .289 xBA (97th percentile).
• Pivetta has heavily leaned on his four-seam fastball (53.8%), and Lee bats .315 against the pitch in 2026. 

Add Jung Hoo Lee to your PrizePicks lineup now.

Make Padres vs. Giants Picks for Sunday Night Baseball on PrizePicks

With a thin margin for error, the Padres continue their pursuit of the final Wild Card spot in the National League. Following back-to-back wins vs. the Giants, San Diego seeks a sweep on Sunday Night Baseball.

Don’t wait until the first pitch — make your Padres vs. Giants picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 36 states.

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