The 2026 MLB season is here, as the New York Yankees and San Francisco Giants take the diamond for Opening Night. Everyone is 0-0 with hopes to knock off the two-time defending champion Los Angeles Dodgers, starting with Wednesday's contest at 8:05 p.m. ET on Netflix.
The Yankees are coming off a 94-win campaign, losing in the ALDS to the eventual American League-winning Toronto Blue Jays. The Giants finished at 81-81, missing the postseason for the fourth straight year.
In addition to stats like home runs, hits, and pitcher strikeouts, there are also First Inning Runs Allowed projections to consider on PrizePicks and PrizePicks Team Picks. This is a way to get real-money action on "Yes Run First Inning" (YRFI) or "No Run First Inning" (NRFI) picks in the first frame of MLB games.
Below, we’ll break down our top YRFI/NRFI pick for Yankees vs. Giants on Opening Night. Make your MLB picks on PrizePicks and earn real money if you’re right, including on game winners, run lines, and totals!
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Will There Be a First Inning Run in Yankees vs. Giants?
First Inning Run Payout on PrizePicks Team Picks: Yes 2.17x | No 1.69x
SP Max Fried takes the hill for the Yankees on Opening Night, coming off a career-high 19 wins in his first season in pinstripes. That mark led the AL, while his 189 strikeouts were the seventh-most.
Here is some data on how Fried fared in the first inning in his 32 starts last season:
- Allowed a run in the first inning in seven of 32 starts (25%).
- Didn't yield a run in the opening frame in his last seven starts of the year.
- Posted a 1.97 ERA in the first inning (top-15 lowest in the majors), giving up 7 runs in 32 innings.
The 2025 Yankees scored in the first inning in 65 of 162 regular-season games. That 40.12% clip of scoring was the highest in baseball. On the other side, they allowed a first-inning run in only 38 games (23.5%), the third-lowest share in baseball.
SP Logan Webb takes the hill for the Giants. Last year, he made a career-high 34 starts, tying a career-high with 15 wins. 2025 marked Webb's third consecutive season of over 200 innings, finishing with an NL-high 207 frames pitched. He also led the NL in strikeouts with a career-high 224.
Here's how Webb performed in the first inning in his 34 starts.
- Allowed a run in the first inning in nine of 34 starts (26.5%).
- Produced a 3.71 ERA in the first inning, surrendering 14 runs in 34 frames.
The Giants were just behind the Yankees, scoring a first-inning run in 54 of 162 games, third-most in the league. However, they allowed more first-inning runs than New York did, doing so in 48 of 162 opening frames, close to the league average.
Make YRFI & NRFI Picks on PrizePicks
The 2026 MLB season is here, with all 30 teams taking the field over the next three days. Get in on the YRFI & NRFI action with PrizePicks' First Inning Runs Allowed category.
You can make your 2026 MLB World Series and division future picks on PrizePicks and PrizePicks Team Picks to earn real money. With Team Picks, make predictions on winners, run lines, and over/unders, now available in 35 states.
Keep tabs on the Playbook for continued MLB predictions, picks, and news.
