April is here, and on Wednesday, April 1, the MLB games are full of daytime action with a pair of games under the lights tonight.
Today's best MLB predictions below focus on the AL Central battle between the Minnesota Twins (1-3) vs. Kansas City Royals (2-2) at 7:40 p.m. ET, followed by the Cleveland Guardians (3-3) vs. Los Angeles Dodgers (4-1) game at 8:20 p.m. ET.
Which MLB games could bring us the best spots for game predictions on PrizePicks Team Picks and PrizePicks? Below, we’ll highlight two games for MLB predictions and expert picks, including two MLB game picks and one player pick to target.
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Best MLB Predictions, Expert Picks Today: Wednesday, April 1
While there's plenty of daytime MLB action today, we'll focus on the two night games on Wednesday – Twins vs. Royals, and Guardians vs. Dodgers.
Keep tabs on the Playbook’s MLB coverage for predictions on baseball all season leading up to the World Series. Let’s dive into our favorite MLB predictions and expert picks for Wednesday, April 1, on PrizePicks Team Picks.
Payouts from PrizePicks Team Picks are live as of publishing. All are subject to change.
Minnesota Twins vs. Kansas City Royals Prediction to Win – 4/1/26
Game Winner Pick: Minnesota Twins (1.81x payout) | Kansas City Royals (1.92x)
Time: 7:40 p.m. ET
- The Royals captured the series opener on Tuesday, 3-1, highlighted by a pair of home runs from LF Issac Collins and CF Kyle Isbel.
- Kansas City allowed 6 runs in each of its first two losses at Atlanta, but the Royals have given up 2 runs in the past two wins.
- The Twins dropped two of three at Baltimore, including blowing a 4-0 lead in Sunday’s 8-6 defeat.
- P Joe Ryan takes the mound for Minnesota after allowing 1 hit and striking out 7 batters in 5.1 innings against Baltimore in a 2-1 season-opening loss.
- The Twins compiled a 2-1 record in Ryan’s two starts against the Royals last season. The right-hander gave up 1 run in 12 innings of the two victories.
- Royals P Noah Cameron yielded 1 run in 12.1 innings in two starts against Minnesota in 2025.
- However, Cameron’s xERA last season sat at 4.08, compared to a 2.99 ERA.
- In two games against left-handed starting pitchers, the Twins have scored a total of 2 runs.
- The Royals rank last in MLB in BABIP at .220 and 28th in wOBA at .262, according to Fangraphs.
Cleveland Guardians vs. Los Angeles Dodgers Prediction to Win – 4/1/26
Game Winner Pick: Cleveland Guardians (3.03x) | Los Angeles Dodgers (1.33x)
Time: 8:20 p.m. ET
TV: ESPN Unlimited, MLB.tv
- The Guardians have alternated wins and losses through their first six games, coming off last night’s 4-1 defeat.
- The Dodgers trailed in each of their first four games, but won three times.
- Los Angeles is 8-5 in P Yoshinobu Yamamato’s 13 starts at Dodger Stadium, but all five losses came as a -175 favorite or higher.
- Cleveland won eight of P Gavin Williams’ final 10 regular season starts of 2025, but he dropped his opening outing at Seattle.
- All five starting pitchers to face the Guardians have eclipsed their strikeout projection. Cleveland owns the third-highest K% in MLB at 29.5%.
- Yamamoto has recorded 207 strikeouts since the start of 2025. According to BaseballSavant.com, 92 of those Ks came via the split-finger.
- The Dodgers post the fourth-best barrel rate in MLB at 10.4%, compared to Cleveland at 7.5%.
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Guardians vs. Dodgers Pick: Guardians P Gavin Williams – 5 Strikeouts
- Williams picked up 7 strikeouts in his season debut at Seattle in five innings. However, he handed out 6 walks and threw 89 pitches in a 5-1 defeat.
- In last season’s matchup with the Dodgers, the right-hander was limited to 3 strikeouts in less than 5 innings of work. He allowed 10 baserunners (4 hits and 6 walks) and racked up 109 pitches.
- The Dodgers have not struck out more than five times against an opposing starting pitcher in six games.
- The Los Angeles lineup owns the third-lowest K rate in the league at 18.5%.
Make Your MLB Predictions on PrizePicks
Although the daytime MLB slate is stacked, both of these evening MLB games are intriguing showdowns. The Twins look to stunt the Royals with Joe Ryan on the mound, while the Guardians try to knock off the Dodgers as heavy underdogs. Check out the Playbook for nonstop MLB coverage.
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Stick around with the Playbook for continued MLB predictions, picks, and news throughout the 2026 season.
