A monster 15-game MLB slate slate gives us plenty of opportunities for MLB DFS on Tuesday. We’ve got today’s top MLB DFS picks for MLB today, including pitchers and hitters to target on PrizePicks for today’s slate, plus a home run pick.
Whether you’re backing pitchers' strikeouts or a hitter’s home run, Tuesday MLB slate is stacked with opportunities on PrizePicks. Below, we’ve got six picks to help you build your winning Lineups for Tuesday MLB.
Don’t forget to head to the PrizePicks MLB board, lock in your picks, and submit your Lineup to get in on the real money MLB action before the first pitch.
MLB DFS Picks on PrizePicks: Tuesday, 4/15
Here are the top MLB DFS picks and predictions for PrizePicks today. Use this analysis to build your Lineups on PrizePicks MLB on Tuesday, April 15. Click to read more about each pick.
- Reds SS Elly De La Cruz — 1.5 Hits+Runs+RBIs
- Mariners P Luis Castillo — 4.5 Hits Allowed (Goblin)
- Red Sox P Walker Buehler — 2.5 Earned Runs
- Phillies OF Nick Castellanos — 1.5 Hits+Runs+RBIs
- Guardians 3B Jose Ramirez 2.5 Total Bases (Demon)
- Home Run Pick: Mets 1B Pete Alonso
Reds SS Elly De La Cruz — 1.5 Hits+Runs+RBIs
- Mariners P Luis Castillo has struggled through three starts in 2025, allowing a 16% barrel rate, a 49% hard‑hit rate, and a 33% fly‑ball rate in 93 plate appearances, despite surrendering only four earned runs in 17 innings.
- Castillo throws the fastball more than 40% of the time.
- Reds SS Elly De La Cruz has punished the fastball by posting a 20% barrel rate, a 65% hard‑hit rate, and a 33% fly‑ball rate in 170+ plate appearances.
- De La Cruz has at least 2 Hits+Runs+RBIs in three of his last four games.
Mariners P Luis Castillo — 4.5 Hits Allowed (Goblin)
- As a team, the Reds have posted a strong 8% barrel rate, a 42% hard‑hit rate, a 31% fly‑ball rate, and a .285 BABIP in 1,000 plate appearances against fastballs since last season.
- Wind is blowing more than 10 mph out towards center field.
- Across his last 13 starts, Castillo has given at least four hits in 12 of them.
- He has given up at least four hits in each of his last 10 starts on the road.
Note: Goblin picks reduce your payout on PrizePicks, as they are easier projections to hit.
Red Sox P Walker Buehler — 2.5 Earned Runs
- Red Sox P Walker Buehler surrendered a 14% barrel rate, a 50% hard‑hit rate, and a 28% fly‑ball rate over his last 85+ plate appearances, resulting in 10 earned runs across three starts in 2025.
- Rays hitters posted a .325 BABIP, a 46% hard‑hit rate, and a near 10% barrel rate against the 4-seam fastball this season which Buhler throws more than 35% of the time.
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Phillies OF Nick Castellanos — 1.5 Hits+Runs+RBIs
- Over his last 50+ appearances against right‑handed hitters, Giants P Justin Verlander allowed an 11% barrel rate, a 48% hard‑hit rate, and a 37% fly‑ball rate, relying on fastballs 45% of the time.
- Phillies OF Nick Castellanos matches up well against Verlander’s fastball, in 130+ plate appearances owns a 10% barrel rate, a 54% hard‑hit rate, and a 28% fly‑ball rate.
- Verlander has struggled so far this season, giving up at least five hits in every game with a 6.92 ERA, but his 3.74 xFIP suggests he is getting unlucky.
Guardians 3B Jose Ramirez —2.5 Total Bases (Demon)
- Newly acquired Orioles P Charlie Morton surrendered an ugly 17.5% barrel rate, a 75% hard‑hit rate, and a 20% fly‑ball rate to right‑handed hitters in 65+ plate appearances this season.
- José Ramírez has demolished right‑handed pitching in 35+ plate appearances, posting a 14% barrel rate, a 48% hard‑hit rate, and a 41% fly‑ball rate.
Note: Demon picks increase your payout on PrizePicks, as they are harder projections to hit.
Home Run Pick: Mets 1B Pete Alonso
- Twins P Bailey Ober has allowed a brutal 10% barrel rate, a 70% hard‑hit rate, and a 36% fly‑ball rate in 55+ plate appearances against his fastball in 2025.
- Mets 1B Pete Alonso has punished the fastball in 21 plate appearances with a 21% barrel rate, a 58% hard‑hit rate, and a 43% fly‑ball rate.
- Alonso has hit four home runs across 55 at-bats this year, despite a 1.136 OPS (fourth best in MLB).
Note: Demon picks increase your payout on PrizePicks, as they are harder projections to hit.
Most Popular NBA Picks on PrizePicks Today
Here are the most popular NBA PrizePicks picks for Tuesday, April 15. These are the players selected most in NBA Lineups as of 3 p.m. ET.
- Orioles P Charlie Morton — 2.5 Earned Runs Allowed (Demon)
- Marlins SS Xavier Edwards — 7 Hitter Fantasy Score
- Diamondbacks OF Corbin Carroll — 8 Hitter Fantasy Score
- Yankees P Max Fried — 5.5 Pitcher Strikeouts
- Rays 1B Yandy Diaz — 7 Hitter Fantasy Score
- Mariners OF Julio Rodriguez — 7 Hitter Fantasy Score
- Phillies DH Kyle Schwarber — 0.5 Hits
Cash in on MLB DFS on PrizePicks
With a loaded Tuesday MLB slate, now is the time to get in on the action on PrizePicks. Just build your MLB Lineup on PrizePicks and win real money if your picks are correct.
All you have to do is pick More or Less on at least two player projections — like hits or pitcher strikeouts — to win.
Whether you’re going with demons or goblins, there’s always real money sports action waiting for you on PrizePicks. Stay locked in on the Playbook all season long for MLB player picks every day.
