MLB DFS Picks Today: Top Plays for PrizePicks MLB - 5/6/25

Tuesday brings a loaded MLB DFS slate, including a doubleheader between the Guardians and Nationals. However, weather could have an impact on the slate with rain possible for a few games, including in Colorado and Boston. Still, there are some intriguing matchups to enjoy, including when the Cubs host the Giants.

Whether you want to attack home runs, fantasy score, or pitcher strikeouts, the Tuesday MLB slate is filled with opportunities to cash in on PrizePicks. Let’s highlight today’s top MLB DFS picks to help you build your Lineups for today’s MLB action.

Be sure to head to the PrizePicks MLB board, lock in your picks, and submit your lineup to get in on the real money MLB action before the first pitch. If you’re new to PrizePicks, you can claim a $50 free bonus after your first $5 Lineup.

Best MLB DFS Picks on PrizePicks: Tuesday, 5/6

Here are some of the top MLB DFS picks and predictions on PrizePicks today. Use this analysis to help you build a stacked MLB Lineup on PrizePicks for Tuesday, May 6. Click each pick to read more.

• Dodgers OF Shohei Ohtani – 2.5 Hits+Runs+RBI
• Dodgers 1B Freddie Freeman – 9 Hitter Fantasy Score
• Yankees OF Cody Bellinger – 5.5 Hitter Fantasy Score
• Padres P Michael King – 6 Strikeouts
• Home Run Pick: Athletics OF Lawrence Butler

Dodgers OF Shohei Ohtani – 2.5 Hits+Runs+RBI

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• Dodgers OF Shohei Ohtani went 1-for-4 with a home run, two RBI, two runs scored, one walk, and one stolen base in the series opener against the Marlins on Monday.
• Over his last nine games, Ohtani is 13-for-34 (.382) with a .512 OBP, three home runs, four doubles, two triples, five RBI, and 14 runs scored.
• Ohtani will face Marlins RHP Cal Quantrill, who has a 1.80 WHIP this season after posting a 1.52 WHIP last year.
• After recording a 1.128 OPS against right-handed pitchers last year, Ohtani has a 1.047 OPS against them this season.

Dodgers 1B Freddie Freeman – 9 Hitter Fantasy Score

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• Dodgers 1B Freddie Freeman is currently on a 10-game hitting streak.
• During his hitting streak, Freeman is 17-for-38 (.447) with a .523 OBP, three home runs, three doubles, 12 RBI, and nine runs scored.
• Freeman has a 1.272 OPS against right-handed pitchers this year.
• For his career, Quantrill has allowed a 4.71 xFIP and a 1.39 WHIP to left-handed hitters, including a 4.99 xFIP to lefties this year.

Yankees OF Cody Bellinger – 5.5 Hitter Fantasy Score

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• Yankees OF Cody Bellinger has just four multi-hit games this season.
• Bellinger is batting .202 with a .280 wOBA.
• After posting a strikeout rate of 15.6% in both of the last two seasons, Bellinger has a 20.6% strikeout rate this year.
• The Padres will start P Michael King, who has a 3.31 xFIP and a 1.01 WHIP this season.

Padres P Michael King – 6 Strikeouts

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• Padres P Michael King has recorded at least seven strikeouts in four of his seven starts.
• King has a 29.5% strikeout rate this year, which is up from 27.7% last season.
• King has a whiff rate of at least 33.3% on his slider, sweeper, and four seamer.
• The Yankees have struck out the fourth-most times (317) in baseball.

Home Run Pick: Athletics OF Lawrence Butler

• After hitting 22 home runs over 125 games last season, Athletics OF Lawrence Butler has five home runs over 34 games this year.
• Since the start of 2024, Butler has hit 21 of his 27 home runs against right-handed pitchers.
• The Mariners will start P Emerson Hancock, who has allowed a home run in three of his four starts this season.
• Hancock has allowed 1.6 HR/9 for his career.
• Hancock has allowed a career slugging percentage of .477 on the road, compared to .441 at home.

Make MLB DFS Picks, Win Cash on PrizePicks

There will be no shortage of action across baseball Tuesday with all 30 teams scheduled to take the field. That also means plenty of star power to focus on, both at the plate and on the mound.

A packed MLB schedule Tuesday makes for plenty of options to consider on PrizePicks. Now is the time to build your MLB DFS Lineup on PrizePicks.

Just pick More or Less for at least two MLB player stat projections to build your Lineup on PrizePicks and win real money if your picks are correct. Check out the Playbook for more daily MLB picks throughout the season.