MLB DFS Picks Today: Expert Fantasy Baseball Picks for PrizePicks – 5/19/25

It’s an all-MLB Monday. While we await the conference finals in the NBA and NHL, we have a loaded 12-game slate in the MLB. Teams will kick-off their mid-week series on Monday night to give us plenty of exciting action in tonight’s MLB games.

Below, we’ll give you the best MLB DFS picks for Monday’s MLB slate, including pitcher and hitter picks to target for PrizePicks MLB.

PrizePicks is the easiest way to cash in on your MLB takes. Just pick More or Less on state projections — from pitcher strikeouts to hitter fantasy scores — and get paid if your picks are right. It’s the best way to play fantasy baseball. 

New to PrizePicks? Sign up and get $50 instantly here.

Let's get into the MLB DFS picks for Monday, May 19, on PrizePicks.

Reds P Nick Lodolo — 17.5 Pitching Outs (Goblin)

• The Pirates are sporting a 53 wRC+ and .198 batting average in the last 14 days — both bottom two in the MLB over that span.
• Reds P Nick Lodolo has pitched least 90 pitches in each of his last six games
• Lodolo has pitched for at least 18 outs in five of his nine starts this year.

Note: Goblin picks reduce your payout on PrizePicks, as they are easier projections to hit.

Rockies P Kyle Freeland — 16.5 Fantasy Score

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• Rockies P Kyle Freeland has given up at least three runs in every home start this season, in the altitude of Coors Field.
• Freeland has scored less than 10 fantasy points in three of his last five starts.
• Freeland is getting crushed by right-handed bats this year, and he’s projected to face seven righties in this Phillies lineup.
• Freeland has given up a ridiculous .442 wOBA at home this year, plus a .382 to right-handed batters in all starts.
• Freeland is 0-6 as a starter this year.
• Freeland has only gone over 91 pitches in one of his nine starts this year, with none coming at home.
• The Phillies rank eighth in batting average over the last two weeks, including an above-average wRC+ of 104.

Orioles 2B Jackson Holliday — 1.5 Hits+Run+RBI

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• Brewers P Quinn Priester has struggled vs left-handed batters this year — surrendering a .398 wOBA, 6.09 xFIP, and 1.8 HR/9.
• Holliday has at least two hits in each of the last three games, including a home run in each of the last two games.
• Holiday has been impressive vs. right-handed pitching, with a 141 wRC+, .205 ISO, and just an 18% K rate this year.

Dodgers DH Shohei Ohtani — 2.5 Hits+Runs+RBI

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• The Dodgers are the top hitting team in the league over the last two weeks, with a 151 wRC+ and .390 wOBA.
• Diamondbacks P Brandon Pfaadt, despite his low expected numbers, is giving up 35.7% hard-hit rate to lefties, and a 1.65 HR/9.
• Ohtani has gone more than 2.5 Hits+Runs+RBIs in 10 of his last 13 games.
• Ohtani has hit four home runs across his last five games. 
• The Diamondbacks’ bullpen ranks 24th in MLB with a 4.50 xFIP over the last two weeks.

Play MLB DFS Today on PrizePicks

We have 12exciting games on the Monday MLB slate as new series get underway, including the Dodgers against the Diamondbacks to wrap up the night. There’s no better time to get in the action to win real money on PrizePicks. 

Just build your MLB Lineup on PrizePicks by picking More or Less and win real money if your picks are correct. 

All you need to do is pick More or Less on at least two player projections — like total bases or pitcher strikeouts — to win real cash.

Whether you go with demons or goblins, there’s always real money sports action waiting for you on PrizePicks. Stay locked in on the Playbook all season long for MLB player picks every day.