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MLB DFS Picks & PrizePicks MLB Cheat Sheet – 5/22/25

Mariners C Cal Raleigh is a top MLB DFS pick today in the PrizePicks MLB Cheat Sheet for Thursday, May 22.
AP Photo/Stephen Brashear

Thursday brings a bit of a tricky slate across MLB. There are nine games scheduled to be played, four of which have early start times. There are also some potential rain issues among the evening games, as the Red Sox game was canceled, and the Pirates game is in danger of postponement. Still, there are some intriguing MLB DFS picks to consider on PrizePicks.

Whether you want to attack home runs, hits, or pitcher strikeouts, the Thursday MLB slate provides plenty of opportunities on PrizePicks. Let’s highlight some picks to help you build your Lineups for Thursday’s MLB action.

Be sure to head to the PrizePicks MLB board, lock in your picks, and submit your lineup to get in on the real money MLB action before the first pitch. Get started on PrizePicks today to get $50 free after your first $5 Lineup.

Mariners C Cal Raleigh – 1.5 Hits+Runs+RBI

MLB DFS Picks - Cal Raleigh
  • Mariners C Cal Raleigh is 9-for-32 (.281) with a .368 OBP, four home runs, three doubles, eight RBI, and six runs scored over his last nine games.
  • Raleigh has hit at least 30 home runs in each of the last two seasons.
  • Raleigh has a .954 OPS this season, which is on pace to be the highest mark of his career.
  • Raleigh has a career .355 wOBA and .287 ISO on the road, compared to a .298 wOBA and .184 ISO at home.
  • The Astros will start Lance McCullers Jr., who has a 2.13 WHIP through his first three starts of the season. He had previously not pitched in the majors since 2022 because of injuries.

Nationals SP Trevor Williams – 2.5 Earned Runs Allowed

MLB DFS Picks - Trevor Williams
  • Nationals SP Trevor Williams has allowed at least three earned runs in seven of his nine starts this season.
  • Williams also faced the Braves in his last outing, giving up four runs (three earned) across 4.1 innings.
  • Williams does not miss many bats, posting a 19.0% strikeout rate for his career.
  • Williams has allowed a 40.3% hard-hit rate this season, which is on pace to be the highest mark of his career.
  • Left-handed pitchers have limited the Braves to a .659 OPS this season, but the Braves have a .724 OPS versus righties.

Make MLB Picks, Win Cash on PrizePicks

Of the nine games scheduled to be played in baseball Thursday, five of them have evening start times. Among the more appealing matchups will be the Tigers hosting the Guardians.

Thursday’s schedule provides plenty of options to consider on PrizePicks. Now is the time to build your MLB Lineup on PrizePicks.

Just pick More or Less for at least two MLB player stat projections to build your Lineup on PrizePicks and win real money if your picks are correct. 

Check out the Playbook for more MLB DFS picks throughout the season.

Get in the game! Sign up for PrizePicks and cash in on your sports predictions. Play $5 and get $50 instantly in Lineups with promo code PLAYBOOK.

Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state. Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results. Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.

about the author

Mike Barner has been covering fantasy sports since 2007. He specializes in the NBA, NFL, and MLB. He is a two-time finalist for the Fantasy Sports Writers Association Basketball Writer of the Year award and won the 2021-22 FSGA NBA Experts Champions league. In addition to PrizePicks, Mike has written for Sports Illustrated, RotoWire, SportsLine, and more.

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