We have a fantastic slate of MLB games for Tuesday, with some interesting series, including the Dodgers heading to Cleveland to take on the Guardians at 6:10 p.m. ET.
Below, we’ll focus on the top MLB DFS picks for Tuesday as every team is in action today.
Tuesday’s MLB Cheat Sheet for MLB DFS includes pitchers and hitters to target on PrizePicks in your Lineups.
Don’t forget to head to the PrizePicks MLB board, lock in your picks, and submit your Lineup to get in on the real money MLB action before the first pitch.
Best MLB DFS Picks on PrizePicks: Tuesday, 5/27
Here are the best MLB DFS picks and predictions for PrizePicks today. Use this analysis to build your PrizePicks MLB Lineups on Tuesday, May 27. Click to read more about each pick.
- Braves P Spencer Strider – 1.5 Earned Runs Allowed (Goblin)
- Giants P Logan Webb – 6.5 Strikeouts (Demon)
- Red Sox LF Jarren Duran – 0.5 Total Bases (Goblin)
- Blue Jays 1B Vladimir Guerrero Jr. – 0.5 Runs (Demon)
Braves P Spencer Strider – 1.5 Earned Runs Allowed (Goblin)
- Braves P Spencer Strider has made two starts since returning from a year-long absence after recovering from Tommy John surgery.
- In those two starts, Strider has allowed a total of six earned runs in 9.1 innings.
- Strider is depending on his fastball and is throwing it on 57.6% of his pitches.
- Strider once had a fastball that hit triple digits. It has lost velocity, going from 97.2 MPH in 2023 to 95.2 this season.
Note: Goblin picks reduce your payout on PrizePicks, as they are easier projections to hit.
Giants P Logan Webb – 6.5 Strikeouts (Demon)
- Giants P Logan Webb has suddenly become a strikeout pitcher, with his 26.9% strikeout rate being 4.5% better than his career total.
- Although limited to only 30 plate appearances, Webb has an impressive 40% strikeout rate against the Tigers' roster.
- The Tigers tend to walk away from the plate empty, as their 23% strikeout rate ranks 22nd this season.
Note: Demon picks add a payout boost to your lineup on PrizePicks, as they are more difficult projections to hit.
Red Sox LF Jarren Duran – 0.5 Total Bases (Goblin)
- Red Sox LF Jarren Duran has been hitting well lately, batting .287 in May, and has cleared this projection four of his last seven games.
- Duran has been able to grab multiple bases throughout the year as he’s done so in 23 of 45 games in 2025.
- He will face off against Aaron Civale today, with whom he is 4-for-8 lifetime with a double.
- In 2024, Civale gave up a 4.65 xFIP to right-handed bats, as opposed to 3.93 xFIP vs. lefties.
Note: Goblin picks reduce your payout on PrizePicks, as they are easier projections to hit.
Blue Jays 1B Vladimir Gurerro Jr. – 0.5 Runs (Demon)
- Blue Jays 1B Vladimir Gurerro Jr. has successfully crossed home plate in 14 of his last 18 games.
- He’s been getting on base with both hits and walks, and has reached base in 45-of-52 games this season.
- He has reached base against Texas starter Nathan Eovaldi in 11-of-24 plate appearances.
- Guerrero has 18 runs this month, with a .294 batting average.
Note: Demon picks add a payout boost to your lineup on PrizePicks, as they are more difficult projections to hit.
Lock in on MLB DFS Today on PrizePicks
There are fantastic games on the Tuesday MLB slate, including the Angels facing the Yankees, and the Reds vs. Royals. There’s no better time to get in on the MLB action on PrizePicks.
Just build your MLB Lineup on PrizePicks and win real money if your picks are correct.
All you have to do is pick More or Less on at least two player projections — like total bases or pitcher strikeouts — to win real cash.
Stay locked in on the Playbook all season long for MLB DFS picks every day.
