The Monday, July 21 MLB slate showcases a full slate of 15 games, including a key American League matchup. Headlining the MLB DFS slate today, the Yankees and Blue Jays meet in Toronto at 7:07 p.m. ET, as the Jays seek their fourth consecutive victory.
Welcome to Monday’s MLB DFS Picks, as we’ll break down today’s MLB games and give you the best MLB DFS picks for PrizePicks for July 21, including pitcher strikeout projections and hitter projections to target today.
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Let’s break down some of the best MLB player picks to target for the Monday MLB DFS slate on PrizePicks.
MLB DFS Picks on PrizePicks: Monday, 7/21
Here are some of the top MLB DFS picks and predictions on PrizePicks today, including fantasy scores to target. Use this analysis to help you build a stacked MLB Lineup on PrizePicks for Monday, July 21. Click each pick to read more.
- Phillies RF Nick Castellanos — 5.5 Hitter Fantasy Score
- Blue Jays SS Bo Bichette — 6 Hitter Fantasy Score
- Athletics P Jacob Lopez — 5.5 Strikeouts
- Mariners P George Kirby — 5 Strikeouts
Phillies RF Nick Castellanos — 5.5 Hitter Fantasy Score

- Phillies RF Nick Castellanos struggled this past weekend against the Angels, going 2-of-9 at the plate.
- Castellanos has driven in one run in the last five games, while not picking up a single extra-base hit.
- In four of the past five games, Castellanos has racked up five fantasy points or less.
- In nine career at-bats against Red Sox P Walker Buehler, Castellanos has two hits.
- Castellanos doesn’t draw many walks, posting a 5.5% walk rate (18th percentile). Buehler issues a bases on balls rate of 9.6%, which is the second-highest of his career.
Blue Jays SS Bo Bichette — 6 Hitter Fantasy Score

- Blue Jays SS Bo Bichette has put together a terrific July, batting .354 and posting five multi-hit games.
- Bichette compiled a total of seven fantasy points in the first two wins against the Giants before putting up 16 points on Sunday.
- Bichette has done most of his damage at home this season, batting .319 at Rogers Center to go along with 10 of his 12 home runs.
- Yankees P Carlos Rodon has struck out Bichette three times in 11 at-bats.
- Bichette is tied with teammate Vladimir Guerrero, Jr. for the league lead in xBA at .315. On the flip side, Rodon allows an XBA of .210 (89th percentile) and a whiff rate of 32.1% (90th percentile).
Athletics P Jacob Lopez — 5.5 Strikeouts

- Athletics P Jacob Lopez has recorded at least five strikeouts in six of his last seven starts.
- In Lopez’s lone start against Texas this season, the left-hander put up four strikeouts in less than three innings at work.
- The two teams with the fewest strikeouts against opposing starting pitchers are Kansas City and Toronto. Lopez compiled a total of 14 K’s in two starts against those clubs.
- The Rangers have struck out 46 times in the last five games against opposing starting pitchers.
- Eleven of the last 14 opposing left-handed starting pitchers have recorded at least five strikeouts against Texas.
- Lopez’s strikeout rate ranks in the 83rd percentile in MLB at 27.9%.
Mariners P George Kirby — 5 Strikeouts

- Mariners P George Kirby has picked things up recently in the strikeout department, delivering six K’s against Detroit and nine punchouts against Pittsburgh.
- Kirby will be tested against a red-hot Milwaukee club that has struck out five times or less in nine of the last 10 games against opposing starters.
- One thing Kirby excels at is limiting walks. He owns a BB rate of 5.4% (89th percentile), facing a Brewers’ squad that walks at a 9% clip (tied for seventh in MLB).
- Kirby will get opponents to chase out of the strike zone, posting a 32.6% rate (90th percentile). Two Milwaukee batters to keep an eye on from the chase perspective are RF Jackson Chourio (37.7%) and 1B Andrew Vaughn (32.4%).
- In three of 10 starts this season, Kirby has eclipsed six strikeouts, while only doing so once at home against Pittsburgh on July 6 with 9 K’s.
Make MLB DFS Picks on PrizePicks
There’s exciting action on Monday’s MLB slate, including seven interleague matchups. With 15 MLB games on tap, now is time to build your MLB Lineup on PrizePicks.
Just pick More or Less at least two MLB player stat projections to build your Lineup on PrizePicks. Use the players above to build your Lineups around, or use a 6-Pick Lineup to reach up to 2000x payouts.
Check out the Playbook for more MLB DFS picks and analysis all the way through the season.