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Mets vs. Dodgers Prediction, MLB Picks for Wednesday, April 15

Mets SP Clay Holmes deals a pitch vs. the Athletics.
AP Photo/Frank Franklin II

Mets vs. Dodgers is set for first pitch at 10:10 p.m. ET on Wednesday, April 15, televised by ESPN. The Dodgers have a 1.42x payout if they win via PrizePicks.

With two wins against the Mets already in hand, the Dodgers will start SP Shohei Ohtani (1-0, 0.00 ERA) to try and earn the sweep. The Mets will turn to SP Clay Holmes (2-1, 1.50 ERA) to try and salvage the final game.

Below, we’ll break down our Mets vs. Dodgers prediction and picks for Wednesday’s MLB game, including game winner, over/under, and key player picks for PrizePicks.

Make your picks for Mets vs. Dodgers on PrizePicks now.

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Mets vs. Dodgers Prediction, Winner Payout, Over/Under – Wednesday, April 15

After being held scoreless in three of their last four games, the Mets scored 1 run in their loss to the Dodgers on Tuesday. During their seven-game losing streak, they scored 2 or fewer runs six times. For the season, they have scored the fifth-fewest runs (63) in baseball.

The Dodgers continue to play without SS Mookie Betts (oblique), but his absence has not hindered their lineup. The team has the highest OPS in baseball (.838) and has hit the most home runs (29). Their hitters show good command of the strike zone, posting a 10.9% walk and a 22.9% strikeout rate, per FanGraphs.


Mets vs. Dodgers Winner Payout, Over/Under – Wednesday, April 15

The Dodgers enter Wednesday’s game as a home favorite against the Mets, returning a 1.44x payout if they win outright, via PrizePicks Team Picks

Here are the full payouts for the Mets vs. Dodgers game on PrizePicks.

  • Spread: Dodgers -1.5 (1.96x payout)
  • Over/Under: 7.5 runs (1.78x payout on Over)
  • Gamer Winner Payout: Mets - 2.63x | Dodgers - 1.44x

Play the Mets vs. Dodgers winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!

Team picks data is live as of publishing and is subject to change.


Mets vs. Dodgers Prediction on Winner – 4/15/26

Here are the key game stats and trends behind our Mets vs. Dodgers prediction on the winner for Wednesday, April 15.

Lock in your Mets vs. Dodgers prediction on PrizePicks before the line moves.

  • The Dodgers were 52-29 at home last year. With wins over the Mets the last two days, they are 8-3 in Dodger Stadium this season.
  • After posting the second-highest home OPS (.768) in baseball last season, Los Angeles has nearly equaled that mark at .758 this year.
  • Ohtani has allowed only 5 hits and 4 walks across his 12 scoreless innings.
  • According to FanGraphs, the two-way star had a 2.17 xFIP and a 0.71 WHIP at home last season. On the road, he posted a 2.67 xFIP and a 1.31 WHIP.
  • The Mets have a strikeout rate of only 20.9%, but their .112 ISO is the lowest mark in the majors.

Mets vs. Dodgers Player Picks, Stats for PrizePicks – 4/15/26

Here are top Mets vs. Dodgers picks to target on PrizePicks for Wednesday, April 15. Today's MLB picks for PrizePicks include Andy Pages and Clay Holmes.

Dodgers OF Andy Pages vs. Mets Projection: 4.5 Hitter Fantasy Score

  • Although Pages went 0 for 3 with 2 strikeouts on Tuesday, he already has 8 multi-hit games this season.
  • While he doesn’t have the platoon advantage against Holmes, Pages hit 24 of his 27 home runs last season versus right-handed pitching.
  • According to FanGraphs, the emerging outfielder has a career .382 wOBA and .232 ISO in Los Angeles. On the road, he has a .286 wOBA and a .139 ISO.
  • Pages touts a 55.6% hard-hit rate out of the gate. That’s a significant improvement over his career 39.3% hard-hit rate.

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Mets SP Clay Holmes vs. Dodgers Projection: 4 Strikeouts

  • A former reliever, Holmes generally doesn’t throw many pitches.
  • Last season, he threw at least 100 pitches in just three of his 33 outings. He threw 90 or fewer pitches 23 times.
  • In his first three starts this season, Holmes has yet to top 90 pitches. He came away with 3 or fewer strikeouts in each of them.
  • The former Yankee had a 25.1% strikeout rate as a reliever in 2024, but converting to a starter last season left him with an 18.2% strikeout rate.
  • Holmes often has command issues, which can limit his ability to pitch deep into games. He had a 9.3% walk rate last season and issued 8 walks over 18 innings this year.

Make Mets vs. Dodgers Picks on PrizePicks

The Dodgers will go for the sweep of the Mets on Wednesday, with Ohtani scheduled to take the mound. The Mets have already been struggling at the plate, so this matchup might not help matters. Pages will try to stay hot when he faces Holmes, who has shown an inability to rack up strikeouts since becoming a starter.

Don’t wait until the first pitch — make your Mets vs. Dodgers picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

Stay locked in on Playbook for daily MLB predictions, picks, and news every day all the way through the 2026 MLB season.

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Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state. Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results. Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.

about the author

Mike Barner has been covering fantasy sports since 2007. He specializes in the NBA, NFL, and MLB. He is a two-time finalist for the Fantasy Sports Writers Association Basketball Writer of the Year award and won the 2021-22 FSGA NBA Experts Champions league. In addition to PrizePicks, Mike has written for Sports Illustrated, RotoWire, SportsLine, and more.

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