The Seattle Mariners (12-10) and St. Louis Cardinals (8-13) will meet in the second of their three-game series on Saturday, April 25, at 2:15 p.m. ET, with the Mariners returning a 1.63x payout on PrizePicks Team Picks if they secure a victory.
The Mariners took the first game on Friday and have a chance to take the series with a win today.
Below, we'll break down our Mariners vs. Cardinals prediction and picks for Saturday’s MLB matchup, including the run line, over/under, and key player picks for PrizePicks.
Make your picks for Mariners vs. Cardinals on PrizePicks now.
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Mariners vs. Cardinals Prediction, Winners Payout, Over/Under – Saturday, April 25
Mariners SP Bryan Woo (4.23 xFIP across 5 starts and 32 IP in 2026) and Cardinals SP Matthew Liberatore (5.04 xFIP across 5 starts and 27 IP in 2026) will square off on the mound.
Woo is having one of the best starts of his career in Seattle's rotation. His current 2.48 xERA is a personal best, and his control has been remarkable, with a 4.9% walk rate in the 90th percentile, per Baseball Savant.
Unfortunately, the Mariners’ offense is underperforming, currently ranking 22nd in wOBA (.312) and 28th in hard-hit percentage (36.3%).
It’s been an inconsistent start for Liberatore; over five appearances, he’s allowed 1 earned run in three starts but gave up 4 earned runs in his other two outings. Opponents are making excellent contact with a 7.7% barrel rate that’s in the 49th percentile, and he’s only garnering an 18.1% whiff rate.
The Cardinals’ lack of power has been disappointing, ranking 20th with .391 xSLG.
Mariners vs. Cardinals Winner Payout, Over/Under – Saturday, April 25
The Mariners enter Saturday’s game as road favorites, returning a 1.63x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Mariners vs. Cardinals game on PrizePicks.
- Spread: Mariners -1.5
- Over/Under: 7.5
- Game Winner Payout: Mariners - 1.63x | Cardinals - 2.12x
Play the Mariners vs. Cardinals winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!
Team Picks data is live at the time of writing and is subject to change.
Mariners vs. Cardinals Prediction on Over/Under – 4/25/26
Here are the key game stats and trends behind our Mariners vs. Cardinals prediction on the run total for Saturday, April 25.
Lock in your Mariners vs. Cardinals prediction on PrizePicks before the line moves.
- The Cardinals 56.5% over rate is the 10th-highest in the league.
- It’s likely due to St. Louis totaling 4.6 runs per game (12th).
- The Cardinals’ bullpen is struggling, with a 4.97 xFIP that ranks 27th in MLB.
- The total has gone over in four of five of Liberatore’s starts.
- The Mariners are starting to play in higher-scoring games, with the total going over in three of their last five.
Mariners vs. Cardinals Player Picks, Stats for PrizePicks – 4/25/26
Here are the top Mariners vs. Cardinals picks to target on PrizePicks for Saturday, April 25. Today’s MLB picks for PrizePicks include Bryan Woo and Josh Naylor.
Mariners SP Bryan Woo vs. Tigers Projection: 5 Strikeouts
- Woo has exceeded 5 strikeouts in three of his five starts.
- Although it’s only a small sample size, the Cardinals’ lineup has a .184 xBA and 50.0% strikeout rate in 16 at-bats against Woo.
- The Cardinals tend to swing and miss, with a 26.5% whiff rate that ranks 16th in MLB.
- The 2021 sixth-round pick could also find success by throwing the ball off the plate due to the Cardinals ranking 16th with a 29.7% chase rate.
Add Bryan Woo to your PrizePicks Lineup now.
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Mariners 1B Josh Naylor vs. Cardinals Projection: 4.5 Hitter Fantasy Score
- Naylor has success against Liberatore, posting a .709 xSLG with a home run.
- He has exceeded his hitter fantasy score projection in three of his last four games.
- The 2015 No. 12 overall pick has been hot recently, as his .536 wOBA ranks 14th since April 17.
- The former Guardian rarely strikes out, posting a 6.3% strikeout rate that puts him in the 80th percentile.
- Liberatore does not strike out many batters, with his 13.7% strikeout rate being in the 10th percentile.
Add Josh Naylor to your PrizePicks Lineup now.
Make Mariners vs. Cardinals Picks on PrizePicks
The Mariners look to keep their momentum going with their fifth win over the last seven games. Plus, another win on Saturday would clinch this series against the Cardinals.
Don’t wait until the first pitch happens — make your Mariners vs. Cardinals picks on PrizePicks now and earn real money if you’re right.
Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.
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