Wednesday brings a packed MLB schedule across baseball. Not only will every team be in action, but there are three doubleheaders. One of the more intriguing matchups will be the Guardians vs. Cubs at 8:05 p.m. ET on ESPN. The Cubs defeated the Guardians on Tuesday and remain atop the standings in the NL Central.
Below, we'll give you the top Guardians vs. Cubs predictions and player picks for Wednesday's game, including projections to target on PrizePicks.
Whether you want to attack home runs, hits, or pitcher strikeouts, Guardians vs. Cubs provides plenty of opportunities on PrizePicks.
Be sure to head to the PrizePicks MLB board and lock in your MLB predictions to get in on the real money MLB action before the first pitch. Find more PrizePicks MLB picks in the PrizePicks MLB Cheat Sheet today for Wednesday, July 2.
Guardians vs. Cubs Prediction, Picks – July 2, 2025
Here are three of the top Guardians vs. Cubs picks and predictions on PrizePicks MLB today. Click each pick to read more.
- Cubs SP Shota Imanaga – 4.5 Hits Allowed
- Guardians SP Tanner Bibee – 96.5 Pitches Thrown
- Guardians OF Steven Kwan – 5 Fantasy Score
Cubs SP Shota Imanaga – 4.5 Hits Allowed
- Cubs SP Shota Imanaga recently missed more than a month with a hamstring injury.
- In his first start since being activated off the IL, he allowed one hit and threw 77 pitches over five innings against the Cardinals.
- Given how long he was out and that he only threw 77 pitches in his last start, Imanaga might remain on a limited pitch count against the Guardians.
- In his rehab start, he threw 72 pitches, then 77, so we could expect a mid-80s outing here as he's ramped up to 100 percent.
- The Guardians have the fewest hits in baseball and are batting just .220 against left-handed pitchers this season.
- Even in full outings this year, Imanaga has given up five or more hits in three of eight starts.
Guardians SP Tanner Bibee – 96.5 Pitches Thrown
- Guardians SP Tanner Bibee threw 96 pitches over six innings against the Blue Jays in his last start.
- Bibee has thrown 96 or fewer pitches in 10 of his 16 starts this season.
- Bibee has a 1.31 WHIP on the road this season, compared to a 1.02 WHIP at home.
- The Cubs have scored the second-most runs and have the fourth-highest OPS (.772) in baseball.
Guardians OF Steven Kwan – 5 Fantasy Score
- Guardians OF Steven Kwan is 3-for-21 (.143) with one RBI and no runs scored over his last five games.
- Kwan has no home runs and just two RBI over his last 15 games.
- While Kwan does a good job of avoiding strikeouts, he only has a 2.1% barrel rate and a 21.4% hard-hit rate this season.
- Kwan has a .849 OPS versus right-handed pitchers this season, but lefties have limited him to a .628 OPS.
Make MLB Predictions on PrizePicks
The Guardians and Cubs will battle again Wednesday after the Cubs emerged victorious from Tuesday’s game. It will be a matchup of aces with Imanaga facing off against Bibee.
Wednesday’s Guardians vs. Cubs matchup provides some intriguing projections to make predictions on PrizePicks. Now is the time to build your MLB Lineup and cash in on your predictions.
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