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Guardians vs. Cubs Picks Today – 7/1/25

Guardians 3B Jose Ramirez celebrates a home run. Jose Ramirez is a top Guardians vs. Cubs pick today on PrizePicks.
AP Photo/Paul Sancya

The Guardians and Cubs will begin a three-game series in Chicago with both teams in playoff contention to start July.

Below, we'll break down the top Guardians vs. Cubs picks and predictions and give you the best MLB DFS picks for PrizePicks, including pitcher and hitter projections to target today, Tuesday, July 1.

Chicago is holding onto first place in the NL Central with a two-game lead, while the dominance of the Tigers will prevent them from winning the AL Central, but they are only three games out of the last Wild Card spot. These two will square off under the bright lights of Wrigley Field at 8:05 p.m. ET on Tuesday, July 1, live on TBS.

For Cleveland, Gavin Williams (4.27 xFIP) gets the start coming off a tough outing where he allowed four runs to the Blue Jays. Cubs SP Matthew Boyd (4.01 xFIP) is also on the mound, and had an impressive start against St. Louis, where he went six scoreless innings for the third time this season.

Be sure to head to the PrizePicks MLB board to lock in your MLB picks to get in on the real money MLB action before the first pitch.

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Guardians vs. Cubs Picks – Tuesday, July 1

Here are the top Guardians vs. Cubs picks and predictions for tonight’s game on PrizePicks MLB. Click to read more about each pick. 

⚾️  Find more PrizePicks MLB DFS picks for Tuesday here

Guardians 3B Jose Ramirez – 6.5 Hitter Fantasy Score

Guardians vs. Cubs Picks - Jose Ramirez
  • After a red-hot May where Guardians 3B Jose Ramirez had a .458 weighted on-base average, June had not been as successful as that number was at .328
  • Good luck getting Ramirez to come away empty-handed. His 16.1% whiff rate is in the 89th percentile, and his 11.1% strikeout rate is in the 95th percentile.
  • Wrigley Field has not been kind to Ramirez, as he only has a .185 BABIP at the stadium.
  • Ramirez has had success against Matthew Boyd by going 12-41 with three home runs and 12.3% whiff rate.

Cubs RF Kyle Tucker – 7.5 Hitter Fantasy Score

Guardians vs. Cubs Picks - Kyle Tucker
  • Cubs RF Kyle Tucker has been on fire recently with a .431 weighted on-base average and is leading the team with six RBI over the last six games.
  • Tucker has been locked in throughout the season, with his +25 batting run value being in the 98th percentile. 
  • Tucker has been disciplined at the plate with his 17.5% chase rate being in the 98th percentile and a 14.1% strikeout rate in the 87th percentile.
  • He is one of only two current Cubs players that has faced Guardians starter Gavin Williams; he has one hit in three at-bats. Williams primarily throws a four-seam fastball, with Tucker hitting .290 off that pitch this season.

Guardians SP Gavin Williams – 2.5 Earned Runs

Guardians vs. Cubs Picks - Gavin Williams
  • Guardians SP Gavin Williams has a respectable 3.68 ERA, but there might be some luck involved. His 4.35 expected ERA is only in the 30th percentile.
  • This could be a tough start for Williams against the Cubs, who continue to be one of the best offenses in the league. Chicago is second in runs per game (5.39), third in expected batting average (.265), and third in expected slugging percentage (.464).
  • Control has been a significant issue for Williams all season, as his 12.9% walk rate ranks in the fifth percentile. Chicais go a respectable 12th in walk rate this season (8.8%).
  • Keeping the ball on the best part of the bat has been a struggle for Williams throughout the season, as his 9.0% barrel rate is in the 38th percentile. The Cubs are seventh in barrel rate this season.

Make MLB Predictions on PrizePicks

The Guardians head to the North Side of Chicago in an interleague matchup against the Cubs, getting started today on Tuesday, July 1.

This game between the Guardians vs. Cubs gives us some intriguing player predictions to consider on PrizePicks.

There is a ton of player stat projections available to choose from to make MLB predictions on PrizePicks. Just pick More or Less at least two player stat projections to build your Lineup on PrizePicks.

Check out the Playbook throughout the remainder of the MLB season for more analysis for your PrizePicks and MLB DFS Lineups.

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about the author

John is a graduate from Quinnipiac University with a Master’s Degree in Sports Journalism. With almost 15 years working in radio, TV and blogs, it includes stops at ESPN, NBC Sports, and Audacy. Along with being an avid sports fan, he is into fitness and cooking.

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