The San Francisco Giants (2-3) got swept by the New York Yankees to begin the 2026 MLB season, but they have bounced back in their series against the San Diego Padres (1-4).
The Giants have won the opening two games of the series vs. their in-state rival, including a 9-3 victory on Tuesday.
The Giants vs. Padres game on Wednesday, April 1, is the series finale, with Padres SP Nick Pivetta opposing Giants SP Adrian Houser on the mound. The afternoon MLB game will start at 4:10 ET, with the Padres returning a 1.63x payout to win on PrizePicks Team Picks.
Below, we’ll break down our Giants vs. Padres prediction and game picks for Wednesday afternoon’s game. Make your MLB picks on PrizePicks and earn real money if you’re right, including on game winners, spreads, and totals!
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Padres vs. Giants Prediction, Game Winner, Over/Under – Wednesday, April 1
These two teams are ranked 26th (Giants) and dead last (Padres) in wRC+, both under 75 each, to start the MLB season, as both have struggled to generate much offense.
During that Yankees series, where the Giants were swept, San Francisco was outscored 13-1.
However, the Giants have rebounded in a big way, winning two consecutive games to begin their series against the Padres. San Francisco squeaked out a 3-2 win on Monday, paced by a home run from offseason signee OF Harrison Bader.
On Tuesday, the Giants’ lineup jumped all over Padres SP German Marquez with four runs over the first three innings. SS Wily Adames and 3B Matt Chapman launched home runs, and San Francisco ended up not relinquishing its lead in a 9-3 win.
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Meanwhile, the Padres’ lone victory came in a 3-0 decision against the Detroit Tigers in their season-opening series. Still, San Diego dropped two of the three games in that series and has gotten off to a lackluster start after being eliminated in the NL Wild Card Round in the 2025 playoffs.
The Padres are 29th in the league in home runs (2), last in batting average (.182), and have an ISO under .075 as a team to this point, also last.
Giants vs. Padres Game Winner Payout, Over/Under – 4/1/26
The Padres enter Wednesday’s home game as favorites, returning a 1.63x payout on PrizePicks Team Picks if they win outright.
The Giants are the road underdogs with a 2.27x payout if they win, via PrizePicks Team Picks, where you can earn money with your picks in 35 states.
- Spread: San Diego Padres -1.5 (2.38x payout)
- Over/Under: 7.5 (1.78x payout on over)
- Game Winner Payout: Giants 2.27x | Padres 1.63x
Team Picks data is live at the time of writing and is subject to change.
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Giants vs. Padres Prediction on Over/Under – Wednesday, April 1
Here are the key stats to know before locking in your Giants vs. Padres prediction on the over/under for Wednesday, April 1, on PrizePicks.
- The over is 4-3 in the last seven meetings between the Giants and Padres, including Tuesday’s game producing an over.
- Despite a nine-run outburst on Tuesday, the Giants have scored the fourth-fewest runs (13) in the majors in 2026.
- San Francisco is currently averaging just 2.6 runs per contest.
- Meanwhile, the Padres rank second-to-last in runs scored (12) in the majors up to this point.
- San Diego has averaged 2.4 runs per game in its five contests so far and has scored no more than three runs in any game.
- Padres SP Nick Pivetta has had his fair share of struggles when facing the Giants in his career. In nine career starts, Pivetta has racked up a 4.34 ERA despite having a 4-1 record.
- Pivetta was shelled in his first start of the 2026 season, as he surrendered six earned runs on seven hits in just 3.0 innings vs. the Tigers.
- The Giants produced a 75-77 over/under record in 2026 (11th in the MLB), while the Padres ranked fourth-worst with a 70-90 mark — both teams leaning to the under.
- The two teams have combined to produce a 3-6-1 record when it comes to over/under in 2026 thus far.
Giants vs. Padres Picks for PrizePicks MLB Today – 4/1/26
Here are two of the top Giants vs. Padres picks to consider for Wednesday, April 1. Today’s MLB picks for PrizePicks are headlined by Padres 3B Manny Machado and Giants SP Adrian Houser.
Padres 3B Manny Machado vs. Giants Projection: 1.5 Hits+Runs+RBIs
- Manny Machado has registered just one hit in 13 career at-bats against Giants SP Adrian Houser.
- The Padres slugger has recorded a 20.0% strikeout rate in 2026, which is the second-highest rate of his career.
- The right-handed Machado has tallied just one hit and three strikeouts in 14 plate appearances vs. right-handed pitchers this season.
- Machado will be batting cleanup (fourth) today vs. Houser – he typically bats third in the order.
Giants SP Adrian Houser vs. Padres Projection: 3.5 Ks
- In 21 starts last season, Houser averaged 4.38 strikeouts per contest across 125.0 innings pitched.
- According to FanGraphs, Houser recorded a 3.98 xFIP in away starts throughout the 2025 season.
- Houser significantly relies on the ground ball to get hitters out as he produced a 48.9% ground ball percentage in 2025, per FanGraphs.
- The veteran SP recorded at least four strikeouts in 13 of his 21 outings throughout the 2025 campaign.
- In 13 innings in spring training with the Giants – his first innings with the team, Houser tossed 11 strikeouts, closing the campaign with two 5-inning outings.
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Make Giants vs. Padres Picks on PrizePicks
The Giants have compiled back-to-back wins to begin their series against the Padres, who are struggling to get anything going offensively.
Will San Francisco be able to complete the sweep in Wednesday’s matinee affair, or will San Diego get back on track at home?
You can make your Giants vs. Padres picks on PrizePicks and PrizePicks Team Picks to earn real money. Just pick MLB players, predict More or Less on their projected stats, and cash in if you’re correct. And with Team Picks, make predictions on MLB game winners, spreads, and over/unders, now available in 35 states.
Stick around with the Playbook for continued MLB predictions, picks, and news throughout the 2026 season.
