The first pitch for the San Francisco Giants vs. Los Angeles Dodgers game is set for 10:10 p.m. ET on Tuesday, May 12, with the Dodgers entering as home favorites, returning a 1.29x payout if they win, via PrizePicks.
Game 2 of the four-game series takes place tonight. The Giants won the first series of the season 2-1 and got off to a good start of this series by winning Game 1 9-3. Will the Dodgers rebound tonight against their fierce rival?
Below, we'll break down our Giants vs. Dodgers prediction and picks for Tuesday’s MLB game, including the spread, over/under, and key player picks for PrizePicks.
Make your Giants vs. Dodgers picks on PrizePicks now.
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Giants vs. Dodgers Prediction, Spread, Over/Under – Tuesday, May 12
The Giants may be 17-24, in the basement of the NL West, and last in the division with a -42 run differential, but you wouldn’t think so when watching these two teams play this season.
Following last night’s win, the Giants are now 3-1 against their long-time rivals and seem to play their best baseball when they see Dodger Blue in the other dugout. San Francisco had multi-hit games from their second, third, fourth, fifth, and sixth hitters, which was a pleasant sight for Giants fans considering they came in with the 28th-ranked offense in baseball.
The Los Angeles Dodgers are on a three-game losing streak, which, coupled with the Padres' two-game win streak, has seen L.A. drop out of first place in the NL West for the first time this season.
Los Angeles is half a game back of the Padres for the lead in the division, but brighter times could be ahead considering its +63 run differential is the third-best total in baseball. The offense has combined for just 7 runs during the losing streak. Dodgers SS Mookie Betts returned from injury last night and could help the cause.
Giants vs. Dodgers Spread, Over/Under – Tuesday, May 12
The Dodgers enter Tuesday’s game as home favorites against the Braves, returning a 1.29x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Giants vs. Dodgers game on PrizePicks.
- Spread: Los Angeles Dodgers -2.5 (2.04x payout)
- Over/Under: 8.5 (1.85x payout on Over)
- Game Winner Payout: Giants - 3.33x | Dodgers - 1.29x
Play the Giants vs. Dodgers spread or over/under on PrizePicks Team Picks to earn real money — available in 35 states!
Team Picks data is live at the time of writing and is subject to change.
Giants vs. Dodgers Prediction on Spread – 5/12/26
Here are the key game stats and trends behind our Giants vs. Dodgers prediction on the run line for Tuesday, May 12.
Lock in your Giants vs. Dodgers prediction on PrizePicks before the line moves.
- The Giants have the seventh-worst against the spread (ATS) record at 18-23-0 (43.9%).
- The Giants had the second-worst ATS record last year at 74-88-0 (45.7%). The only team worse was the Colorado Rockies.
- Over the last seven days, the Dodgers have had a team BABIP of .252. That is the seventh-worst in the majors during that timespan, but it could indicate a team that is due for some positive regression soon.
- The Giants as a team have an 86 wRC+, which is the third-worst in the majors. This is with them having a team BABIP of .296, ranking as the eighth-highest in MLB.
- The Dodgers also have a huge bullpen advantage with their seventh-ranked BP (3.69 xFIP) going up against the Giants' 23rd-ranked pen (4.59 xFIP).
Giants vs. Dodgers Player Picks, Stats for PrizePicks – 5/12/26
Here are the top Braves vs. Dodgers picks to target on PrizePicks for Tuesday, May 12. Today’s MLB picks for PrizePicks include Adrian Houser and Yoshinobu Yamamoto.
Giants SP Adrian Houser vs. Dodgers Projection: 3 Strikeouts
- Houser has just a 4.71 K/9 this season and is generating almost no swing and miss.
- He has dealt more than 3 strikeouts in just one of his seven starts this season.
- His 8.8% swinging-strike rate is well below average and suggests a pitcher not necessarily due for much positive strikeout regression.
- The Dodgers are striking out just 20.8% of the time as a team this season, seventh-fewest in the major leagues.
- In his last three starts, Houser has thrown just 77, 68, and 74 pitches. This means he has a short leash and could be the victim of a quick hook if he struggles early.
Add Adrian Houser to your PrizePicks Lineup now.
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Dodgers SP Yoshinobu Yamamoto vs. Giants Projection: 1.5 Walks Allowed
- First, Yamamoto has reduced his walk rate from 3.06 BB/9 in 2025 to 2.06 BB/9 this season.
- Second, Yoshi has only walked more than one hitter in two of his seven starts this season.
- Third, Yamamoto was a notoriously low walk rate pitcher during his time in the NPB. He had a sub-2 BB/9 in his final three seasons in Japan.
- Lastly, you could not ask for a better matchup. The Giants are walking at the lowest rate at a minuscule 5.7% mark.
Add Yoshinobu Yamamoto to your PrizePicks Lineup now.
Make Giants vs. Dodgers Picks on PrizePicks
Despite a lot of playoff basketball and hockey on the TV tonight, there will always be space for a good old-fashioned baseball rivalry. Giants vs. Dodgers is just one of the games for you to get all your action on with PrizePicks.
Don’t wait until lock — make your Giants vs. Dodgers picks on PrizePicks now and earn real money if you’re right.
Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.
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