Two NL West rivals off to slow starts look to turn things around, beginning a three-game set in San Diego. The Padres are listed as home favorites with a 1.78x payout against the Giants at 9:40 p.m. ET on FS1.
San Diego avoided a home sweep against Detroit with a 3-0 shutout on Saturday but scored only 7 runs in the opening three games. It wasn’t much better for the Giants, who were held to 1 run in a three-game home sweep at the hands of the Yankees.
Let's dive into a Giants vs. Padres prediction and some picks for Monday. Make your MLB picks on PrizePicks and PrizePicks Team Picks and earn real money if you’re right, including on game winners, spreads, and totals!
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Giants vs. Padres Prediction, Spread, Over/Under
San Diego owned San Francisco last season, winning 10 of 13 matchups. The Padres grabbed five of six meetings at Petco Park while scoring at least 5 runs in all five victories.
Giants vs. Padres Spread, Over/Under
The Padres enter this matchup as home favorites, returning a 1.78x payout on PrizePicks Team Picks if they win outright.
The Giants are road underdogs with a 1.92x payout if they win, via PrizePicks Team Picks., where you can earn money with your predictions in 35 states!
- Spread: San Francisco Giants -1.5 (2.5x payout)
- Over/Under: 8.5
- Game Winner Payout: Giants 1.92x | Padres 1.78x
Team Picks data is live at the time of writing and is subject to change.
Giants vs. Padres Prediction on Spread – 3/30/26
Here are some key stats to know before locking in your Giants vs. Padres prediction on spread for Monday, March 30 on PrizePicks.
- The Giants were outscored by the Yankees 13-1, with the lone run coming on an RBI single from 3B Matt Chapman in the finale.
- San Diego was shut down in the first two games by Detroit southpaws Tarik Skubal and Framber Valdez, scoring a total of 4 runs.
- San Francisco has produced the fewest hits (13) and lowest batting average (.143) among any team in the league.
- Six teams through the first weekend have hit 1 home run or fewer. The Padres have gone deep once, and the Giants are the only team to not hit a homer.
- Last season, San Diego owned a 32-20 record against NL West foes, while San Francisco posted a 24-28 mark inside the division.
- The Giants compiled a 12-10 record when P Landen Roupp started in 2025, including an 0-3 mark against the Padres. Roupp allowed 9 earned runs in two outings at Petco Park, compared to 6.1 scoreless frames in his lone home start vs. San Diego.
- San Francisco put together a 4-8 record in its final 12 road series openers last season.
Giants vs. Padres MLB Picks for PrizePicks Today: 3/30/26
Here are three top Giants vs. Padres picks to target on Monday. Key PrizePicks player projections are headlined by three players: Giants DH Rafael Devers, Padres P Walker Buehler, and San Diego OF Fernando Tatis Jr.
Giants DH Rafael Devers vs. Padres Projection: 1.5 Hits + Runs + RBIs
- Devers picked up a pair of hits, including a double in Saturday’s 3-1 defeat to the Yankees.
- He is hitless in a pair of at-bats against San Diego P Walker Buehler, including a strikeout.
- Last season, Devers batted 5-of-27 against the Padres, but three of those hits were home runs.
- Devers' road numbers were slightly lower than his home stats. He batted .241 and slugged .445 on the highway, compared to a .262 AVG and a .511 SLG at home.
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Padres P Walker Buehler vs. Giants Projection: 3.5 Strikeouts
- Buehler remained below his strikeout projection in 16 of 24 starts last season with the Boston Red Sox and Philadelphia Phillies.
- The Giants struck out 15 times in the opening series against New York’s starting pitchers.
- His strikeout numbers have dropped considerably since his peak days with the Los Angeles Dodgers. In 2019, Buchler's K% sat at 29.2%. It was 16.3% last year.
- Buehler’s most productive pitch last season was the sweeper, which produced a 34.9% whiff rate and opposing batters hit .130 against that pitch.
Padres OF Fernando Tatis Jr. vs. Giants Projection: 7 Hitter Fantasy Score
- Tatis has struggled out of the gate, going 2-of-11 with a pair of singles.
- He picked up a fantasy score of 12 points in Saturday’s victory over Detroit, including a stolen base (5 points).
- Tatis posted excellent numbers against the Giants last season, hitting .340 while scoring 10 runs and stealing 3 bases.
- In 8 career at-bats against Roupp, Tatis has 5 hits, but only 1 extra-base knock.
Make Giants vs. Padres Picks on PrizePicks
Both San Francisco and San Diego look to break out tonight after struggles in their opening series. Will the Padres continue their dominance against the Giants at Petco Park? There’s never been a better time to add to the excitement of every MLB moment than with PrizePicks.
There's a wide variety of player stat projections on the MLB board. Just pick at least two player stat projections to build your Lineup on PrizePicks. Or, make your picks on winners, spreads, and over/unders on Team Picks, now available in 35 states.
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