As we hit Week 8 of college football, we're entering that stretch of the season where you’ll have games on almost every night of the week — it's a glorious thing. Frida night features four matchups, including premier Power Four programs on the college football schedule for October 17.
Below, we'll give you the top Friday CFB DFS Picks for PrizePicks in Week 8 across the full slate of games tonight.
There’s a Big Ten contest with No. 25 Nebraska taking on Minnesota, featuring Cornhuskers QB Dylan Raiola, who ranks fifth in the Big Ten in passing yards with 1,591.
College football fans are in for a treat, as Heisman candidate Hurricanes QB Carson Beck and No. 2 Miami host Louisville in a highlighted ACC matchup, with Louisville's back against the wall after a loss to Virginia.
Let's get into today's top college football picks in the PrizePicks Cheat Sheet today for Friday, October 17.
Friday CFB DFS Picks for PrizePicks: 10/17/25
Here are the top CFB DFS Picks for Friday in Week 8, including player picks Nebraska vs. Minnesota and Louisville vs. Miami on PrizePicks college football real-money game.
Miami QB Carson Beck vs. Louisville Projection: 241.5 Passing Yards
Louisville vs. No. 2 Miami Pick – 7 p.m. ET
- Beck has more than 241 passing yards in two of his last five games — one vs. a USF defense that is 99th in yards/dropback (7.23) and another vs. FCS school Bethune-Cookman.
- Lousville's defense ranks sixth in yards/dropback (4.43), making this far and away Beck's toughest test yet.
- Despite his Heisman candidacy, Beck is only 21st in expected points added (EPA) per dropback, showing the media's ability to overhype Beck based on his team's performance to this point.
- The transfer from Georgia’s 8.0 average depth of target ranks 84th of 122 quarterbacks with a minimum of 109 dropbacks.
- Louisville is 12th in opponents' average depth of target (6.5).
- Beck is fifth in completion percentage (73.4%).
- The Cardinals are 14th in opponents’ completion percentage (56.5%).
- The Cardinals defense is no slouch — Louisville ranks No. 1 in EPA/dropback allowed (-0.40), and 10th best in available yards percentage surrendered, per Game on Paper.
Nebraska QB Dylan Raiola vs. Minnesota Projection: 245.5 Passing Yards
No. 25 Nebraska vs. Minnesota Pick – 8 p.m. ET
- Nebraska QB Dylan Raiola has more than 245 passing yards in three of his last five games.
- The sophomore is sixth in dropback success rate (51.5%) and 32nd in EPA per dropback.
- Minnesota is 38th in dropback success rate (44.5%), and was dusted by Ohio State QB Julian Sayin, who found his stride to put up 326 yards and 3 TDs two weeks ago.
- The Gophers are 79th in passing yards allowed per game (235.8).
- Nebraska’s offensive line is only allowing pressure on 24.7% of passing plays (17th).
- Minnesota’s defense pressures just 28.5% of passing plays, ranking 116th.
Miami WR Malachi Toney vs. Louisville Projection: 67.5 Receiving Yards
Louisville vs. No. 2 Miami Pick – 7 p.m. ET
- Miami No. 1 WR Malachi Toney has more than 80 receiving yards in three of his last five games.
- The Miami freshman has the second-best PFF receiving grade in passes thrown for 0-9 yards (97.2).
- The three-star recruit’s 137 yards after the catch from passes thrown 0-9 yards ranks second.
- The Cardinals are 12th in opponents’ yards after the catch (2.5) allowed.
- Toney will likely be hedged in coverage by Louisville S Antonio Watts. His 90.1 PFF coverage grade ranks fifth among safeties and has allowed under ten yards after the catch in five of six games.
- Toney has 7 targets or less in four of his last five games.
Louisville RB Isaac Brown vs. Miami Projection: 52.5 Rushing Yards
Louisville vs. No. 2 Miami Pick – 7 p.m. ET
- Isaac Brown has more than 60 rushing yards in two of his last four games against FBS opponents.
- Miami has not allowed an opposing running back to run for over 50 yards this season. The Hurricanes let one opponent run for more than 100 total rushing yards.
- Brown ranks 172nd among running backs with 1.3 yards after contact (minimum 35 carries), per PFF.
- The Hurricanes allow the fewest yards before contact to running backs (0.5).
- Browns' 37.3% rush success rate is 202nd.
- Opponents’ 31.0% rush success rate against The U is the seventh worst.
California RB Kendrick Raphael Projection: 70.5 Rushing Yards
North Carolina vs. California Pick – 10:30 p.m. ET
- Kendrick Raphael rushed for more than 70 yards in one of two games against ACC opponents.
- Raphael ran for 119 yards in Week 5 against Boston College, who are 87th in defensive rush EPA (0.025).
- North Carolina is 123rd in defensive rush EPA (0.080), which ranks as the worst in the ACC.
- UNC is 52nd in yards per carry (4.0).
Make Friday College Football Picks on PrizePicks
Friday night college football schedule brings four electric conference games, including a critical ACC matchup between Louisville vs. #2 Miami. In the Big Ten, Nebraska vs. Minnesota clash to try to stay in contention in their conference, with one falling by the wayside.
No matter what your college football picks are, there's no better way to cash in than with the Friday CFB DFS Picks for PrizePicks.
Just pick More or Less on player stat projections and get paid when your picks are correct — all the way up to 2000x your entry fee.
Check out the Playbook for more CFB DFS picks and college football predictions throughout the season!
