The Los Angeles Dodgers vs. San Francisco Giants game is set for a first pitch at 9:45 p.m. ET on Tuesday, April 21, with Los Angeles returning a 1.49x payout if they win on PrizePicks.
The Dodgers continue their road trip after splitting a four-game set at the Colorado Rockies, coming off a 12-3 rout on Monday. The Giants are back home following a 4-5 swing out east, capped off by a series victory at the Washington Nationals.
Below, we'll break down our Dodgers vs. Giants prediction and picks for Tuesday's MLB game, including the winner, over/under, and key player picks for PrizePicks.
Make your picks for Dodgers vs. Giants on PrizePicks now.
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Dodgers vs. Giants Prediction, Winner Payout, Over/Under – Tuesday, April 21
To no one’s surprise, the defending World Series champion Dodgers (16-6) own the best record in baseball nearly a month in. Los Angeles has lost one of its first seven series, coming to the Cleveland Guardians in the second set of the season.
The Giants (9-13) are still trying to find their way under new manager Tony Vitello. San Francisco started 1-7 at home before posting consecutive shutouts against the Philadelphia Phillies. It’s been nearly two weeks since the Giants have played at Oracle Park.
San Francisco dropped each of its first two series at the Baltimore Orioles and Cincinnati Reds before taking two of three at Washington. The Giants were blanked in Sunday’s finale; San Francisco is 0-3 this season after getting shut out.
The Dodgers captured eight of 13 matchups from the Giants last year, but three of those losses came in series openers.
Dodgers vs. Giants Winner Payout, Over/Under – Tuesday, April 21
The Dodgers enter Tuesday’s game as a road favorite against the Giants, returning a 1.49x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Dodgers vs. Giants game on PrizePicks.
- Spread: Los Angeles Dodgers -1.5 (1.92x payout)
- Over/Under: 7.5 (1.96x payout on Over)
- Game Winner Payout: Dodgers 1.49x | Giants 2.43x
Play the Dodgers vs. Giants winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!
Team Picks data is live at the time of writing and is subject to change.
Dodgers vs. Giants Prediction on Over/Under – Tuesday, April 21
Here are the key game stats and trends behind our Dodgers vs. Giants prediction on the over/under for Tuesday, April 21.
Lock in your Dodgers vs. Giants prediction on PrizePicks before the line moves.
- The Dodgers remain atop the league in xBA at .281, while the Giants rank eighth at .253.
- Los Angeles’ pitching staff is fifth in hard-hit rate at 36.6%, as SP Yoshinobu Yamamoto owns a 31.4% clip in this category.
- The Dodgers have hit the under in each of Yamamoto’s last three starts.
- In Yamamoto’s first start against San Francisco last year, he allowed 5 runs. In the next three outings, he limited the Giants to 1 run on 5 hits.
- The Giants sit 29th in MLB in wOBA at home, batting .269. It’s a drop-off from the road, where San Francisco’s wOBA is .314.
- Three of San Francisco’s top hitters own an xBA below .250. SS Willy Adames (.239), DH Rafael Devers (.231), and C Patrick Bailey (.227) have all struggled, while no Giants regular is hitting above .300 on xBA.
Dodgers vs. Giants Player Picks, Stats for PrizePicks: 4/21/26
Here are top Dodgers vs. Giants picks to target on PrizePicks for Tuesday, April 21. Today’s MLB picks for PrizePicks include SP Landen Roupp and RF Kyle Tucker.
Giants SP Landen Roupp vs. Dodgers Projection: 5 Strikeouts
- Roupp has compiled at least 6 strikeouts in three of four starts, including 7 Ks in his lone home outing against the New York Mets.
- The right-hander owns a career-high 26.7% strikeout rate after posting a 21.7% mark in 2025.
- In his previous start against the Dodgers last July, Roupp put up 8 Ks, his most strikeouts in his last 22 outings.
- The Dodgers are 16th in strikeout rate at 21.8% while averaging 4.94 Ks against right-handed starting pitchers.
Add Landen Roupp to your PrizePicks Lineup now.
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Dodgers RF Kyle Tucker vs. Giants Projection: 6.5 Hitter Fantasy Score
- Tucker looks to extend his five-game hitting streak after sitting out last night’s win at Colorado.
- The former Chicago Cubs standout picked up a fantasy score of at least 7 points in four straight games before getting held to 3 points on Sunday.
- Tucker’s road numbers have been impressive, owning a .361 average and OPS of .997.
- In six of nine games away from Dodger Stadium, Tucker has grabbed more than 7 fantasy points.
Add Kyle Tucker to your PrizePicks Lineup now.
Make Dodgers vs. Giants Picks on PrizePicks
Los Angeles looks to continue rolling atop the NL West with its first matchup against rival San Francisco tonight. Can the Giants pull off the upset and get their offense on track at home?
Don’t wait until lock — make your Dodgers vs. Giants picks on PrizePicks now and earn real money if you’re right.
Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.
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