Dodgers vs. Brewers Prediction, MLB Picks for Friday, May 22

The Los Angeles Dodgers (31-19) begin a three-game series against the Milwaukee Brewers (29-18) on Friday, May 22, with the first pitch scheduled for 7:40 p.m. ET at American Family Field.

According to PrizePicks Team Picks, the Brewers are slight home favorites with a 1.85x payout if they win. Both teams come into this series hot, with the Dodgers 7-3 and the Brewers 8-2 over the last 10 games.

Below, we'll break down our Dodgers vs. Brewers prediction and picks for Friday’s MLB game, including the winner payouts, over/under, and key player picks for PrizePicks.

Make your Dodgers vs. Brewers picks on PrizePicks for Friday night's matchup.

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Dodgers vs. Brewers Prediction, Winner, Over/Under – Friday, May 22

Two of the National League’s best collide in one of the best series of the weekend. L.A. sits second in NL standings, while Milwaukee is third and only half a game back from the Dodgers. Each squad is within striking distance of the first-place Braves, sitting 3.5 and 4.0 games behind the top spot in the National League.

According to PrizePicks Team Picks, the Dodgers have the shortest payout to win the National League (2.38x), while the Brewers are tied with the Cubs for the third-shortest payout (8.33x).

Make your 2026 MLB season predictions on PrizePicks Team Picks.

In the last 10 matchups, Los Angeles is allowing only 2.5 runs per game. That’s in line with FanGraphs crediting the Dodgers with only 159 runs allowed (the fewest) and a 3.50 xERA (third-best).

The Brewers’ pitching has been elite, too, sporting a 3.31 xERA (the best) while allowing only 162 runs (second-fewest). 

Dodgers SP Justin Wrobleski (2.49 ERA, 4.83 xFIP over 7 starts) and Brewers SP Logan Henderson (3.50 ERA, 2.84 xFIP over 4 starts) will get starts for tonight’s series-opening affair.

Wrobleski has enjoyed a breakout season with his 2.49 ERA, but some negative regression came when he allowed 7 earned runs on May 10 vs. the Braves. Henderson was called up from Triple-A after Brewers SP Brandon Woodruff was placed on the 15-day IL in early May. He’s delivered with a 2.81 ERA over three starts in May.

Will the batting orders find success against stingy pitching on Friday night?

Dodgers vs. Brewers Winner Payout, Over/Under – Friday, May 22

The Brewers enter Friday’s matchup as a slight home favorite against the Dodgers, returning a 1.85x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Dodgers vs. Brewers game on PrizePicks.

• Spread: Milwaukee Brewers -1.5 (2.7x payout)
• Over/Under: 8.5 (1.92x payout on Over)
• Game Winner Payout: Dodgers 1.88x | Brewers 1.85x

Play the Dodgers vs. Brewers winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!

Team Picks data is live at the time of writing and is subject to change.

Dodgers vs. Brewers Prediction on Winner – 5/22/26

Here are the key game stats and trends behind our Dodgers vs. Brewers prediction on the winner for Friday, May 22.

Lock in your Dodgers vs. Brewers prediction on PrizePicks before the first pitch.

• Over the last 10 games, the Dodgers have posted 5.4 runs per game, while the Brewers logged 4.6 runs in the same split.
• Los Angeles boasts 119 wRC+ (first), paired with a .432 SLG (second) and .344 wOBA (first).
• Henderson, who ranks as the Brewers’ sixth-best prospect, is currently in the 17th percentile with an 11.1% barrel rate while producing a measly 17.8% ground ball rate (first percentile), per Baseball Savant. 
• The Dodgers make plenty of loud contact with a 10.4% barrel rate (third).
• Henderson is also allowing a lot of lift with a 51.1% flyball rate that’s above the 38.7% league average. Los Angeles’ 13.4% home run-to-fly ball rate (third) is a threat.
• Milwaukee touts a terrific .247 batting average (sixth), but that plummets to .213 against left-handed pitching (28th).
• Wrobleski carries a 5.9% walk rate (86th percentile), which could help limit the Brewers’ impressive 11.2 BB% (fourth).
• The Dodgers’ starter heavily leans on his four-seam fastball with a 51.2% usage rate, and Milwaukee ranks just 15th in runs above average against this pitch.

Dodgers vs. Brewers Player Picks, Stats for PrizePicks – 5/22/26

Here are top Dodgers vs. Brewers picks to target on PrizePicks for Friday, May 22. Today’s MLB picks for PrizePicks include Shohei Ohtani and Justin Wrobleski.

Dodgers DH Shohei Ohtani vs. Brewers: 8.5 Hitter Fantasy Score

• Shohei Ohtani touts only a .486 SLG, which is a large drop compared to .622, .646, and .654 over his last three seasons.
• However, Baseball Savant still credits the two-way superstar with an exceptional .531 xSLG (92nd percentile), fueled by his 17.6% barrel rate (96th percentile) and 49.2% hard-hit rate (88th percentile).
• As mentioned, Brewers SP Logan Henderson has allowed an 11.1% barrel rate (17th percentile). Plus, he’s given up 1 home run in his last two starts.
• Ohtani just launched a big fly on Wednesday and still touts a 17.0% HR/FB that’s above the 10.8% league average.
• With Henderson giving up plenty of lift (51.1% fly ball rate) and a high barrel rate, Ohtani could continue his hot streak.
• Los Angeles’ designated hitter has 10 hits over his previous 19 at-bats (.526).
• While Ohtani carries a sky-high 8.5 hitter fantasy score, he’s averaging an 18.6 score per outing over his last five games, reaching at least 15 points in four of five contests. 

Add Shohei Ohtani to your PrizePicks Lineup now.

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Dodgers SP Justin Wrobleski vs. Brewers: 4 Strikeouts

• Justin Wrobleski has posted 6.0 Ks per start over his last two appearances.
• However, he’s reached 4 strikeouts in only three of eight appearances this season.
• Wrobleski has a 13.3% strikeout rate (fifth percentile), 15.0% whiff rate (second percentile), and a 28.7% chase percentage (37th percentile).
• The Brewers are a tough cookie to crack with a 20.3% K% (fourth-lowest), and that stays low at 21.0% against southpaws (ninth-lowest).
• Milwaukee has tallied only 6.8 Ks per game over its last five contests, dropping from 7.9 on the season (eighth-fewest).
• Furthermore, the Brewers may limit Wrobleski’s chase rate, swinging at only 28.3% of pitches outside the strike zone (the lowest).

Add Justin Wrobleski to your PrizePicks Lineup now.

Make Dodgers vs. Brewers Picks on PrizePicks

Will the Dodgers win Game 1 as an underdog on Friday night? Los Angeles could have the run production advantage, and Wrobleski may have a favorable advantage with Milwaukee struggling against left-handed pitchers.

Don’t wait until the first pitch — make your Dodgers vs. Brewers picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

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