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Cubs vs. Reds Predictions, Picks – Monday, August 4

Reds P Nick Lodolo takes the mound in Cubs vs. Reds tonight, Monday, August, 4, and is a top MLB DFS pick on PrizePicks.
AP Photo/David Zalubowski

The Chicago Cubs (65-46) and Cincinnati Reds (58-54) battle it out tonight at 8:05 p.m. ET to start their series, as both teams look to gain momentum in the NL Central as they head into the last two months of the regular season.

Below, we'll give you Cubs vs. Reds predictions and picks for tonight's game, including for Reds SP Nick Lodolo (8-6, 23.6 K%) and Cubs SP Michael Soroka (3-8, 25.4 K%) strikeout projections.

On PrizePicks, Nick Lodolo's strikeout projection is discounted from 5 to 3.5, to make it that much easier to cash in on your MLB predictions for Cubs vs. Reds today.

Both teams find themselves in very unique situations. The Cubs are sitting in a great position as they are leading the wildcard race and are just two games behind the Brewers yet they have one of the most electric offenses and can jump them in one series.

The Reds on the other hand have struggled a little more thus far yet are just four games out of the last wildcard spot. If able to put together some series wins against divisional opponents such as the Cubs, they can easily find themselves with a chance come October.

Can the Reds battle back into the divisional race or will the Cubs fight closer to the top spot in the NL Central? Either way, there are plenty of ways to win real money on PrizePicks with your MLB predictions.

Cubs vs. Reds Predictions, Picks – 8/4/25

Here are three of the top Cubs vs. Reds picks and predictions to target on PrizePicks today. Use this analysis to help you build your MLB lineup on PrizePicks on Monday, August 4. Click each pick to read more.

Reds P Nick Lodolo — 5 Pitcher Strikeouts

  • Although the Cubs have the fourth lowest strikeouts in all of the MLB, their strikeout rate against left-handed pitching is above league average at 23.3%.
  • Nick Lodolo has been consistently striking out batters all season with a strikeout rate of 23.6% and the 31st most strikeouts amongst all pitchers.
  • Lodolo also excels against right-handed batters with just a .211 BA and .258 OBP, Lodolo’s strikeout rate against opposite side matchups is nearly 26%.
  • With just a 4.6% walk rate, Lodolo fills up the strike zone so expect either hard contact or strikeouts tonight as he attempts to reach this projection like he has in seven of his last ten games.

Cubs P Michael Soroka — 5.5 Pitcher Strikeouts

  • The Cincinnati Reds are one of the most inconsistent disciplined teams in MLB with the tenth most strikeouts but also the eighth most walks this season.
  • Similar to Nick Lodolo, Soroka fills the strike zone with just a 7.0 BB% as he has produced a KK% of 25.4 this season.
  • Soroka also dominates right-handed hitters with a 28% strikeout rate and just a .594 OPS as the Reds are projected to start seven right-handed batters tonight.

Reds SS Elly De La Cruz — 8.5 Hitter Fantasy Score

  • Elly’s switch hitting abilities has allowed him to remain a focal point on this offense. With an xBA of .268 along with a Barrel rate of 12.2%, Elly is a threat to get on base at all times.
  • Against right-handed pitching, Elly is hitting nearly .300 with an OPS of .922 this season.
  • Elly also doesn’t strike out as much as other batters with a K% of just 24.4% and a Whiff rate of just 30.9 on the year.
  • Michael Soroka also struggles slightly more against left-handed batters which is where Elly excels the most as he allows a .328 OBP.

Make Cubs vs. Reds Picks on PrizePicks

With exciting offensive capabilities from both the Cubs and Reds tonight, as well as what could be a star pitching matchup, it's time to make your Cubs vs.Reds predictions on PrizePicks. PrizePicks offers thousands of player stat projections so you can win based on your sports knowledge every day.

Build your MLB Lineup on PrizePicks with your favorite MLB projections and win real money if your picks are correct. All you have to do is pick More or Less on at least two player projections — like hits or pitcher strikeouts — to win.

Stay locked in on the Playbook all season long for MLB DFS picks every day.

Get in the game! Sign up for PrizePicks and cash in on your sports predictions. Play $5 and get $50 instantly in Lineups with promo code PLAYBOOK.

Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state. Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results. Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.

about the author

Austin Wells is a social media manager and content strategist. He’s from Covington, Georgia, and graduated in 2024 with a degree in Business Administration, concentration in marketing. Austin loves all things Philadelphia, including the Eagles and the Sixers, but his MLB fandom lies with the Yankees. He collects baseball cards and has the ultimate goal of visiting every MLB and NFL stadium.

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