Cubs vs. Brewers Prediction, MLB Picks for Friday, June 26

The Chicago Cubs vs. Milwaukee Brewers game is set to get underway at 7:45 p.m. ET on Friday, June 26, televised by Apple TV. According to PrizePicks Team Picks, the Brewers return a 1.35x payout if they come out on top.

Milwaukee is riding a four-game winning streak after sweeping a three-game series against the Cincinnati Reds. Meanwhile, the Cubs are also on a four-game winning streak after winning all four games against the New York Mets in their most recent series.

Below, we'll break down our Cubs vs. Brewers prediction and picks for Friday’s MLB game, including the spread, over/under, and key player picks for PrizePicks.

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Cubs vs. Brewers Prediction, Winner Payout, Over/Under – Friday, June 26

In Friday’s series opener, Brewers SP Jacob Misiorowski (2.12 xFIP across 93.0 innings) will face off against Cubs SP Colin Rea (4.71 xFIP in 79.1 innings) on the mound.

Misiorowski has been extremely dominant this season, leading the majors in ERA (1.45) and strikeouts (138). According to Baseball Savant, Misiorowski has held opposing hitters to a .175 xBA, which ranks in the 98th percentile.

Meanwhile, Rea has landed on the other end of the spectrum, allowing at least 4 earned runs in five of his starts in 2026. The Cubs right-hander tossed 5.1 shutout innings against the Toronto Blue Jays in his most recent start but had yielded 11 earned runs across his previous two outings.

The Brewers and Cubs possess electric offenses that have turned heads this season. According to FanGraphs, Chicago ranks third in wRC+ (107), while Milwaukee comes in sixth with a 104 wRC+.

Cubs vs. Brewers Winner Payout, Over/Under – Friday, June 26

The Brewers enter Friday's game as a home favorite against the Cubs, returning a 1.35x payout if they win outright via PrizePicks Team Picks.

Here are the full payouts for the Cubs vs. Brewers game on PrizePicks.

• Spread: Milwaukee Brewers -1.5 (1.78x payout)
• Over/Under: 7.5 (2x payout on Over)
• Game Winner Payout: Cubs 3.03x | Brewers 1.35x

Make your Cubs vs. Brewers prediction on the winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!

Team Picks data is live at the time of writing and is subject to change.

Cubs vs. Brewers Prediction on Winner – 6/26/26

Here are the key game stats and trends behind our Cubs vs. Brewers prediction on the winner for Friday, June 26.

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• The Brewers are 7-3 in their last 10 games, including a 3-1 home record during that span.
• Misiorowski has allowed 0 earned runs in three of his last four starts. The Brewers’ ace has registered a 39.1% strikeout rate this season, which ranks in the 99th percentile.
• The Brewers have been victorious in seven of Misiorowski’s last nine starts.
• Milwaukee ranks third in runs (407) in the majors, behind only the Washington Nationals (433) and the Los Angeles Dodgers (423).
• The Cubs are 1-7 in Rea’s last eight starts, with the Chicago pitcher lasting less than five innings in four of those outings.
• Milwaukee has a 4-0 record against Chicago in the last four meetings between these NL Central foes.

Cubs vs. Brewers Picks, Player Stats for PrizePicks: 6/26/26

Here are the top Cubs vs. Brewers picks to target on Friday, June 26. Today’s MLB picks for PrizePicks include Brewers 2B Brice Turang and Cubs SP Colin Rea.

Cubs SP Colin Rea vs. Brewers: 2.5 Earned Runs Allowed 

• Rea has allowed at least 3 earned runs in five of his last eight starts.
• He's tallied a 5.51 xERA throughout the 2026 season, which ranks in the 10th percentile.
• The Cubs’ right-hander has produced just a 17.0% strikeout rate, ranking in the 14th percentile.
• Rea has a 1-1 record to go along with a 6.23 ERA and five strikeouts in three career starts against the Brewers.

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Brewers 2B Brice Turang vs. Cubs: 0.5 Singles

• Turang is hitting .296 (8-for-27) with 3 RBIs and 4 runs scored in his last six games.
• The Brewers’ second baseman has laced at least 1 single in four of his last six contests.
• Further, the second baseman has recorded multiple singles in two of his games during that six-game span.
• Turang has recorded a 45.0% hard-hit rate in 2026, which ranks in the 69th percentile.

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Brewers SP Jacob Misiorowski has proven to be unhittable at times during the 2026 season, and Milwaukee has tallied the second-most wins (49) in the majors. As a result, the Brewers could be in a prime position to start off their weekend against the Cubs in the win column.

Don’t wait until the first pitch — make your Cubs vs. Brewers picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

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