Cowboys vs. Eagles Prediction, Spread, NFL Picks for Monday Night Football

Week 7 of the 2026 NFL season concludes with an NFC East showdown as the Dallas Cowboys travel to Lincoln Financial Field to face the Philadelphia Eagles on Monday Night Football at 8:15 p.m. ET on ESPN.

Dallas enters at 2-4 after dropping two straight games to the Tampa Bay Buccaneers and Green Bay Packers. Philadelphia also enters this matchup at 2-4, having lost four straight after opening the season with back-to-back wins.

The biggest storyline entering Monday night is the absence of QB Jalen Hurts, who remains on injured reserve. Preseason darling QB Tanner McKee will start in his place, and he'll have one of his main weapons back with the expected return of RB Saquon Barkley.

Below, we'll break down our Cowboys vs. Eagles prediction and picks for Monday Night Football, including the winner, spread, over/under, and key player picks for PrizePicks.

‍Make your Cowboys vs. Eagles picks on PrizePicks now!

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Cowboys vs. Eagles Prediction, Spread, Over/Under for Monday Night Football – October 26

Dallas enters Monday night's matchup as a 4.5-point favorite against the Eagles on the road, returning a 1.4x payout on PrizePicks with a win.

Here are the full payouts for Cowboys vs. Eagles on PrizePicks.

Make your Cowboys vs. Eagles prediction on the spread or over/under on PrizePicks.

Team Picks data is live at the time of writing and is subject to change.

Unless otherwise noted, data used in this article is from SumerSports, PFF, and Pro Football Reference.

Dallas has the more productive offense entering this matchup, but its defensive struggles have made it difficult to turn that advantage into wins.

The Cowboys are averaging 25.2 points per game and have generated 0.106 EPA per play, ranking sixth in the NFL. They've also converted on 47.2% of their third-down attempts, the fifth-best rate.

Prescott's been a major part of that production, throwing for 1,639 yards, 10 TDs, and 5 INTs through six games while completing 66.3% of his passes. WR CeeDee Lamb, as usual, is his primary target, recording 48 receptions for 577 yards and 4 TDs.

However, the Cowboys' recent offensive struggles are worth monitoring. Dallas scored just 29 total points over its last two games after averaging 30.5 PPG through its first four contests. Prescott also threw 4 of his 5 INTs across the two losses.

Philadelphia's defense can capitalize on those mistakes, but the Eagles will need to generate more pressure and improve their third-down consistency.

The Eagles' offensive outlook is considerably less encouraging without Hurts. Philadelphia has averaged just 14.8 PPG over its last four contests, but McKee now faces a much easier assignment against a Dallas defense that's struggled to stop opposing passing attacks.

Dallas has allowed 26.5 PPG and ranks near the bottom of the league in defensive efficiency. The Cowboys have surrendered 0.154 EPA/play, ranking 31st, while opponents have generated positive EPA on 54.2% of their passing plays.

That creates an opportunity for Philadelphia to find some offensive production, even with its backup under center. However, the Eagles may need Barkley to establish the run and prevent McKee from having to carry the offense on his own.

Cowboys vs. Eagles Prediction on Over/Under for MNF – 10/26/26

Here are the key stats and predictions behind our Dallas Cowboys vs. Philadelphia Eagles over/under prediction for Monday night.

• Despite their two-game skid, the Cowboys still rank in the top 10 in EPA/pass and offensive success rate.
• The Cowboys' passing attack is by far the strength of this team, catching a wonderful matchup against an Eagles defense that ranks 25th in the NFL in EPA/dropback (0.06).
• Both defenses have struggled to consistently get off the field. The Eagles sit 21st in defensive success rate (43.84%), while the Cowboys are 29th (47.89%).
• I'm not worried about Philly missing Hurts tonight, as McKee is more than capable of exploiting this Dallas defense. Opposing QBs have generated 0.327 EPA per dropback against Dallas.
• While McKee won’t have WR DeVonta Smith tonight, he will have Barkley and TE Dallas Goedert, the former of whom could cook a run defense that's 22nd in EPA/carry (-0.04).

Lock in your Cowboys vs. Eagles spread prediction on PrizePicks.

Cowboys vs. Eagles Picks, Player Stats for MNF on PrizePicks: 10/26/26

Here are two Cowboys vs. Eagles player picks to consider on PrizePicks for Monday night, featuring Dak Prescott and Tanner McKee.

Cowboys QB Dak Prescott vs. Eagles: 268.5 Pass Yards

• Prescott is averaging 273.2 passing yards per contest and now faces an Eagles defense ranked in the bottom seven in EPA/pass.
• Dak has averaged 292.8 yards over his last five games and has cleared this projection in four of his six starts overall.
• The Dallas QB's 7.2 intended air yards per attempt and 71.8% on-target rate both rank among the league’s best.
• The Cowboys' two best offensive weapons are Lamb and WR George Pickens, who have combined for 1,005 yards. Their ability to win against different coverages may help Prescott find favorable matchups throughout the game.
• Dallas has called passes on 70.4% of its offensive plays, the highest rate in the NFL. That approach will potentially give Prescott opportunities to add yards, even if the Cowboys build an early lead.

Add Dak Prescott + Cowboys to win to your PrizePicks lineup now.

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Eagles QB Tanner McKee vs. Cowboys: 196.5 Pass Yards

• No QB should have a passing yards projection under 200 against this Cowboys defense that's surrendered 232.7 per game.
• McKee threw for 215 yards in his first start of the season against Carolina and now faces a Dallas pass defense ranked dead last in the NFL in EPA/pass (0.29).
• The Eagles QB has shown the ability to sling the ball when given the opportunity. In his only start in 2024, he threw for 269 yards vs. the Giants, and in his only start in 2025, he threw for 241 vs. the Commanders.
• As 4.5-point underdogs and with a defense that might allow Dallas to score its fair share of points, it stands to reason that McKee could be asked to throw early and often to keep pace.

Add Tanner McKee + Eagles to cover the spread to your PrizePicks lineup now.

Make Cowboys vs. Eagles Picks on PrizePicks

Seasons could be on the line in Monday night's NFC East showdown. Both teams are at risk of falling to 2-5, and with the trade deadline looming, who knows what that could mean for both franchises?

Can Prescott exploit Philadelphia's weaknesses and lead Dallas to a road victory, or will McKee and the Eagles find a way to pick up a big win in front of the home faithful?

Don't wait until kickoff — make your Commanders vs. 49ers picks on PrizePicks Team Picks. Pick players, predict More or Less on their stats, and cash in if you're right. With Team Picks, you can make predictions on NFL game winners, spreads, and over/unders, now available on PrizePicks.

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