Rams vs. Raiders Prediction, Spread, NFL Picks Today – Sunday, October 25

The Rams head to Vegas to face the Raiders in a game that kicks off at 4:25 p.m. ET on FOX. According to PrizePicks, the Rams are 3.5-point road favorites on the spread.

Both teams need wins; the Raiders are on a three-game losing streak, and the Rams have lost two straight. 

Below, we’ll break down our Rams vs. Raiders prediction, followed by player projections via PrizePicks.

Make your Rams vs. Raiders picks on PrizePicks now! 

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Rams vs. Raiders Prediction, Spread, Over/Under – Sunday, October 25

The Rams are a 3.5-point road favorite with a 1.56x payout to win outright, compared to the Raiders' 2.32x payout.

Here are the full payouts for the Rams vs. Raiders on PrizePicks, including winner payouts, the spread, and the over/under. PrizePicks data is live at the time of writing and is subject to change.

Make your Rams vs. Raiders prediction on the spread on PrizePicks.

All stats are via NFL Next Gen Stats, FTN Fantasy, and PFF unless otherwise noted.

Halloween hasn’t arrived yet, and we might already be talking about must-win games. It feels like a matchup where the Rams either win or this season may slip away.

Los Angeles was an early-season favorite to win the Super Bowl, and now its last in the NFC West at 2-4. It’s not like the Rams are only a couple of games out of contention in the division. With the 49ers at 6-0, they have a huge mountain to climb.

Injuries have been brutal for the Rams all season. It started in Week 1 against the 49ers, when they lost newly acquired EDGE Myles Garrett, who will not be available for this game. Garrett and recently unretired DT Aaron Donald were supposed to form one of the league's most dangerous pass-rush duos, but they haven't shared the field.

The wide receiver depth has also taken a hit. The Rams already lost WR Puka Nacua for two games earlier in the season, and he's questionable due to a calf injury he suffered in practice on Thursday. They won't have WR Davante Adams, who is out for 6 to 10 weeks with a ruptured hamstring.

Can the Raiders capitalize on the Rams' injuries and get back into the win column?

Las Vegas had an unexpectedly great start to the season, winning its first three games. However, those victories came against the Dolphins, Chargers, and Saints, who are 2-15 combined.

The Raiders are in the middle of a gauntlet after losing to the Chiefs, Patriots, and Bills. After Week 7, their next opponents include the 49ers, Seahawks, and Broncos.

In those first three games, Raiders QB Kirk Cousins was fantastic, throwing for 9 passing TDs, a 107.2 passer rating, and a 67.6% completion rate. Over the last three games, he has just 3 passing TDs, a 93.1 passer rating, and a 62.5% completion rate. 

We even saw 2026 #1 overall pick Fernando Mendoza get some playing time. Cousins’ time as the starter could be ending soon if the Raiders extend their losing streak.

If Las Vegas wants to pull off this upset, RB Ashton Jeanty and TE Brock Bowers need to be highly involved.

Along with Garrett, the Rams have several defensive players who may not play, including LB Nate Landman (out) and CB Trent McDuffie (questionable). Las Vegas can exploit those matchups with its high-level skill players.

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Rams vs. Raiders Prediction on the Spread – 10/25/26

Here are the key stats and predictions behind our Rams vs. Raiders prediction on the spread for Sunday, October 25.

• The Rams move the ball well, ranking third in total yards per game (401.3). That is where the Raiders are vulnerable, as they rank 28th in total yards allowed per game (371.7).
• Los Angeles excels at converting on third and fourth down, placing sixth in conversion rate (44.0%). Las Vegas ranks 19th on third- and fourth-down conversion rate (42.0%) allowed.
• The red zone matchup could be the deciding factor. The Rams are sixth in red zone attempts per game (4.0), while the Raiders are 24th at 3.8.
• Las Vegas struggles to defend the red zone, allowing a 73.9% conversion rate (26th). This could help Los Angeles, which is 12th in the red zone conversion rate (62.5%).
• Rams RB Kyren Williams has struggled in his last two games, averaging just 49.5 rushing yards. This may be the game he gets back to form, as the Raiders have allowed a 90+ yard rusher in three of their last five games.

Lock in your Rams vs. Raiders prediction on PrizePicks!

Rams vs. Raiders Picks, Player Stats for PrizePicks: 10/25/26

Here are the top Rams vs. Raiders picks to target on Sunday, October 25. Today’s NFL picks for PrizePicks include QB Matthew Stafford and RB Ashton Jeanty.

Rams QB Matthew Stafford vs. Raiders: 253.5 Pass Yards

• Stafford leads the league with 1,794 passing yards; this could be a great matchup against a Raiders pass defense that's 24th in passing yards allowed per game (237.3).
• Stafford is second in air yards (2,208), while the Raiders are 17th in air yards allowed (763).
• Las Vegas surrenders 11.6 yards per completion (28th). This could greatly benefit Stafford, who averages 10.9 yards per completion this season.
• The Raiders are excellent at disrupting the pocket, sporting the third-best pressure rate (30.9%). However, the Rams’ offensive line has been among the best at keeping the pocket clean by ranking ceding the second-lowest pressure rate (16.5%).

Add Matthew Stafford + Rams to your PrizePicks lineup now.

Raiders RB Ashton Jeanty vs. Rams: 25.5 Receiving Yards

• Jeanty is one of the league's top pass-catching running backs, ranking second at the position in receiving yards (251).
• He's also third among running backs in yards after the catch. The Rams rank 16th in YAC allowed (662).
• The Rams struggle to contain dual-threat running backs, allowing the sixth-most receiving yards to the position (241).
• Jeanty performs well on short passes under 10 air yards thanks to +1.4 EPA per reception (seventh). The Rams are 26th in EPA allowed per pass on short passes (-0.12).

Add Ashton Jeanty + Raiders to your PrizePicks lineup now.

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Make Rams vs. Raiders Picks on PrizePicks

The Rams need to get back in the win column after back-to-back losses. The Raiders looked promising with three straight wins to open the season, but they're now going downhill with three straight losses. Who grabs the much-needed win on Sunday?

Don’t wait until kickoff — make your Rams vs. Raiders picks on PrizePicks to win real money if you're right. Just pick your players, predict More or Less on their stats, and cash in on your predictions when you're right.

With PrizePicks Team Picks, make your predictions on game winners, spreads, and over/unders — or combine one with players for even higher payouts.

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