Two recent Super Bowl champions will go head-to-head when the Seattle Seahawks host the Kansas City Chiefs on Sunday Night Football at 8:20 p.m. ET on NBC. Seattle is a 2.5-point favorite on the spread tonight, via PrizePicks.
After a bye week in Week 5, the Chiefs remained undefeated following a 22-6 win against the Chargers in Week 6. Meanwhile, the Seahawks dropped their second consecutive game, falling 17-14 to the Denver Broncos in overtime in Week 6.
Below, we’ll break down our Chiefs vs. Seahawks prediction and picks for Week 7’s Sunday Night Football game tonight, including the spread, over/under, and top player picks for PrizePicks.
Make your Chiefs vs. Seahawks prediction and picks on PrizePicks now!
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Chiefs vs. Seahawks Prediction, Spread, Over/Under for Sunday Night Football
The Seahawks enter Sunday’s game as 2.5-point home favorites against the Chiefs, returning a 1.61x payout if they win outright, via PrizePicks — or an estimated $161 on a $100 entry if you're right.
Here are the full payouts for the Chiefs vs. Seahawks game. PrizePicks data is live at the time of writing and is subject to change.
Make your Chiefs vs. Seahawks prediction on the spread on PrizePicks!
The Chiefs are one of just three undefeated teams in the NFL this season. After missing the playoffs altogether in 2025, Kansas City has gotten off to a 5-0 start, while outscoring its opponents 140-83.
Kansas City made a huge splash in the offseason by signing RB Kenneth Walker III to a three-year, $45 million deal after he helped Seattle win a Super Bowl last season. The Chiefs desperately needed a bell-cow RB, and Walker has fit the bill.
Walker has averaged 133.0 rushing yards per game, scoring at least one TD in each contest. The Chiefs RB rushed for 128 yards and 2 TDs while averaging 6.7 yards per carry against the Chargers in Week 6.
The Chiefs’ bread and butter has been their running game, but having a healthy Patrick Mahomes has made a massive difference. The Kansas City QB is completing 66.5% of his passes for 1,309 yards and 9 TDs with just 3 INTs.
Kansas City will miss star WR Rashee Rice in Week 7 as he deals with hamstring and knee injuries. This marks the second straight game Rice will miss after injuring his hamstring vs. the Raiders in Week 4.
Meanwhile, the Seahawks may have hoisted the Lombardi Trophy in February, but they haven’t gotten off to a great start this season. Seattle has produced a 3-3 record thus far and dropped three of its last four contests.
The Seahawks scored 11 unanswered points against the Broncos last Thursday and forced overtime. However, QB Sam Darnold threw an INT on the Seahawks’ overtime drive, and the Broncos kicked a game-winning field goal to win 17-14.
It’s no secret that the Seahawks’ offensive attack relies heavily on the production of WR Jaxon Smith-Njigba. Smith-Njigba has tallied an NFL-best 717 receiving yards and caught 12 passes for 134 yards against the Broncos in Week 6.
Injuries have hampered the Seahawks' backfield thus far. Rookie RB Jadarian Price is on injured reserve with a chest injury and has missed the last two games. Seattle has also been without veteran RB Zach Charbonnet as he recovers from a postseason ACL tear, and he's set to miss tonight despite three full appearances at practice this week.
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Chiefs vs. Seahawks Prediction on Spread for Sunday Night Football – 10/25/26
Here are the key stats and trends behind our Chiefs vs. Seahawks prediction on the spread for Sunday, October 25.
- The Chiefs are 4-1 against the spread in the last five meetings against the Seahawks. Additionally, Seattle has a 2-4 ATS mark this season, including failing to cover in three of its last four contests.
- Entering Week 7, Kansas City leads the NFL in total yards per game (414.0).
- Much of the Chiefs’ offensive success comes from their rushing attack, led by RB Kenneth Walker III, with an NFL-leading 159.8 rushing yards per game. Kansas City has also posted a 0.099 rush EPA (first), per RBSDM.
- While the Chiefs rely on their running game, QB Patrick Mahomes has been successful, too, averaging 8.2 yards per attempt (fifth among QBs), per PlayerProfiler.
- The Seahawks surrender -0.077 EPA per play, which ranks 25th among NFL teams this season.
- After giving up just 17 points in the first two weeks, Seattle has allowed 26.3 PPG over the past four games.
Make your Chiefs vs. Seahawks picks now for Sunday’s NFL game.
Chiefs vs. Seahawks Picks, Player Stats for SNF on PrizePicks: 10/25/26
Here are the top Chiefs vs. Seahawks picks to target on Sunday, October 25. Today’s NFL picks for PrizePicks include Kenneth Walker III and Jaxon Smith-Njigba.
Chiefs RB Kenneth Walker III vs. Seahawks: 80.5 Rush Yards
- Walker leads all NFL RBs in rushing yards (665) and yards per carry (6.3) in 2026.
- The veteran RB has recorded a 40.8% juke rate, which ranks first among RBs.
- Placing second among RBs, Walker has tallied 438 yards after contact in five games.
- The Seahawks allow 96.0 rushing yards per game (10th), but Walker has rushed for 100+ yards in all but one game and is very familiar with Seattle’s defense as a former Seahawk.
Add Kenneth Walker III + Chiefs to win on PrizePicks.
Seahawks WR Jaxon Smith-Njigba vs. Chiefs: 92.5 Receiving Yards
- Smith-Njigba leads the NFL in receptions (49), receiving yards (717), and receiving TDs (7).
- The Seahawks star has registered a 35.11% target share, ranking first in the league, per SumerSports.
- Smith-Njigba has tallied 210 yards after the catch, which is fourth among wideouts.
- The Chiefs' defense limits teams to a 44.0% dropback success rate (10th).
Add Jaxon Smith-Njigba + Seahawks to cover the spread to your PrizePicks lineup now.
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Make Chiefs vs. Seahawks Picks on PrizePicks
The Chiefs have enjoyed an undefeated start to the 2026 season and will look to keep their stellar play going against the Seahawks on Sunday Night Football. Can Kansas City come away with a road win against the defending Super Bowl champions?
Don't wait until kickoff — make your Chiefs vs. Seahawks picks on PrizePicks now for Week 6 and earn real money if you're right.
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