Cowboys vs. Eagles Prediction, Pick Against the Spread for Monday Night Football

On Monday Night Football, the Dallas Cowboys (2-4) hit the road to face the Philadelphia Eagles (2-4) at 8:15 p.m. ET on ABC and ESPN. The Cowboys enter as 4.5-point road favorites on the spread, per PrizePicks.

The Cowboys are fresh off a 23-13 road loss to the Green Bay Packers and continue to search for answers in what’s been a disappointing campaign thus far.

Meanwhile, the Eagles are in the midst of a four-game skid amidst what’s looking like a lost season. They’ve been plagued by injuries, which includes likely losing starting QB Jalen Hurts for the rest of the year.

Despite both teams’ struggles, the NFC East remains up for grabs if one of them can turn things around. 

Below, we’ll break down our Cowboys vs. Eagles prediction and pick against the spread from PrizePicks for Monday Night Football in NFL Week 7.

Make your Cowboys vs. Eagles prediction on PrizePicks for MNF!

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Cowboys vs. Eagles Prediction, Spread, Over/Under for Monday Night Football – October 26

The Cowboys enter Monday’s game as 4.5-point home favorites against the Eagles, returning a 1.4x payout on PrizePicks if they win outright.

Here are the full payouts for the Cowboys vs. Eagles game on Monday Night Football, via PrizePicks. 

PrizePicks data is live at the time of writing and is subject to change.

Make your Cowboys vs. Eagles prediction on the spread on PrizePicks.

Offense typically hasn’t been the issue for the Cowboys, who enter this matchup averaging the ninth-most PPG (25.2). They’ve relied heavily on the arm of QB Dak Prescott, as Dallas averages the sixth-most passing YPG (267.2) but sits 30th in rush YPG (76.0).

However, Prescott is coming off his second straight mediocre performance, completing 34 of 54 passes for 258 yards, 1 TD, and 2 INTs against Green Bay in Week 6. The Cowboys have failed to score more than 16 points in back-to-back weeks, losing both games. 

Still, this offense ranks fifth in EPA/play (0.109) and sixth in success rate (48.0%), per RBSDM. This attack ought to be fine going forward.

The same can’t be said for the defense, as the Cowboys’ D is 25th in PPG (26.5) and 30th in YPG (382.5). According to FTN, Dallas also ranks last in defensive DVOA. 

The good news is the Cowboys come into Monday relatively healthy, which is something the Eagles wish they could say.

Philadelphia’s injury report is comically long at this point, with a slew of players limited or unable to practice this week. In addition to being without Hurts, the offense will be missing starting WRs DeVonta Smith and Dontayvion Wicks.

While that’s hardly ideal, the Eagles could be getting star RB Saquon Barkley back, as he's reportedly trending toward playing on Monday. That could be a sizable boost for a backfield that’s effectively been down to its fourth-string back, RB Dameon Pierce.

With Hurts sidelined, QB Tanner McKee got his first 2026 start last week against the Carolina Panthers. He posted an unspectacular line, completing 26 of 45 passes for 215 yards and a TD. With Smith and Wicks out, the Eagles may try to rely on the run game tonight, particularly if Barkley is active.

Truth be told, this offense was already struggling with Hurts under center, so McKee might not be a significant downgrade going forward. Overall, the Eagles are 29th in PPG (17.7) and 31st in YPG (255.5), so there’s nowhere to go but up.

Defensively, Philadelphia has been roughly average in PPG (22.8) but ranks 26th in YPG (363.8). It could have its hands full if the Cowboys’ offense can get back on track tonight.

Cowboys vs. Eagles Prediction on Spread for Monday Night Football – 10/26/26

Here are the key stats and trends behind our Cowboys vs. Eagles prediction on the spread for Monday Night Football on October 26.

• The Cowboys’ defense ranks 32nd in EPA/play allowed (0.154) and 29th in success rate (48.6%).
• Dallas has tallied only 8 sacks through six games, which is tied for the league’s second fewest. It's also 29th in pass rush win rate (43%), per ESPN.
• The Cowboys’ defense is dead-last in dropback EPA/play allowed (0.327) by a wide margin. McKee could have an easier time moving the ball in his second start.
• While the Eagles’ offense is near the very bottom in most metrics, it's a less egregious 20th in DVOA.
• If Saquon Barkley can play, he presents a sizable upgrade at RB. Barkley has averaged 5.1 yards per carry and 3.50 yards after contact per attempt, per PFF. Pierce notches 2.1 and 2.43, respectively.   
• Dallas' offense averages just 3.7 YPC and is only 31st in run block win rate (70%). It produces the NFL's fewest rush attempts per game (20.3), too.
• The Cowboys are 1-2 on the road. Their lone win was by 4 points against the Houston Texans.

Lock in your Cowboys vs. Eagles picks on PrizePicks before kickoff!

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Make Cowboys vs. Eagles Picks on PrizePicks

Both the Dallas Cowboys and Philadelphia Eagles enter this matchup on losing skids and desperately need a win if they want to keep pace in the NFC East. Which team will get the victory on Monday Night Football?  

Don't wait until kickoff — make your Cowboys vs. Eagles picks on PrizePicks now for Week 7 and earn real money if you're right.

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