Cardinals vs. Raiders Prediction, Spread, NFL Preseason Picks

The Arizona Cardinals have already partaken in one outing with their Hall of Fame Game loss to the Carolina Panthers, but true Week 1 of this preseason sees them take on the Las Vegas Raiders in a battle between two of the league’s worst clubs from a season ago.

Despite that, both sides are eager to prove that their depth is sufficient to witness improvement in 2026-27. Entering the 8 p.m. ET bout at Allegiant Stadium, hosting Las Vegas is favored by 2.5 points and returns a 1.66x payout on PrizePicks Team Picks with a win. Which side will come out on top on Thursday night?

Below, we'll break down our Cardinals vs. Raiders prediction and picks for Thursday’s NFL preseason game, including the spread, over/under, and key player picks for PrizePicks.

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Cardinals vs. Raiders Prediction, Spread, Over/Under for NFL Preseason – Thursday, August 13

The Raiders enter Thursday’s game as 2.5-point home favorites against the Cardinals, returning a 1.66x payout on PrizePicks Team Picks if they win outright.

Here are the full payouts for the Cardinals vs. Raiders NFL preseason game on PrizePicks.

Make your Cardinals vs. Raiders prediction on spread or over/under on PrizePicks Team Picks — available in 36 states!

Payouts show potential returns on correct Team Picks predictions. A 2x payout returns $200 on a $100 entry. Lower multipliers reflect outcomes users are picking as more likely. Payouts are live as of writing and subject to change.

Cardinals vs. Raiders Prediction on Over/Under for NFL Preseason – 8/13/26

Here are the key game stats and trends behind our Cardinals vs. Raiders prediction on the Over/Under for Thursday, August 13’s game. 

• Neither of these head coaches is a seasoned veteran. Mike LaFleur led his Arizona squad to a near-victory against Carolina exactly a week ago, whereas Klint Kubiak is attempting to translate his offensive coordinator background to a new environment in Las Vegas. 
• The Raiders have a young and hungry defense that ranked as low as third in average age earlier this summer. With plenty of competition but inexperience on that side of the ball, there could be some mistakes made. 
• The Cardinals and Panthers put up a whopping 63 points in the aforementioned Hall of Fame Game, including 26 in the fourth quarter. Arizona gained 23 first downs on the night and averaged 6.5 yards per play in the process.
• These franchises combined with opponents for an average of 40.2 PPG in the 2023-2025 preseasons. 
• 2025’s Raiders defense sat 30th in average opposing starting field position and 21st in points per drive. The Cardinals ranked 26th and 29th, respectively. 

Lock in your Cardinals vs. Raiders prediction on PrizePicks before tonight’s NFL preseason game.

Cardinals vs. Raiders Picks, Player Stats for NFL Preseason on PrizePicks: 8/13/26

Here are the top Cardinals vs. Raiders picks to target on Thursday, August 13. Today’s NFL preseason picks for PrizePicks include QB Jacoby Brissett, RB Jeremiyah Love, and QB Fernando Mendoza.

Cardinals QB Jacoby Brissett vs. Raiders: 31.5 Pass Yards

• LaFleur plans to play his starters on Thursday night, and marquee pieces will get a “max of two” drives. With QB Carson Beck (rib) being held out, though, it remains to be seen whether Brissett could get additional work. The onus is now on him, Gardner Minshew and Kedon Slovis to carry the quarterbacking duties.
• Brissett attempted 16 passes across two preseason games last summer, racking up 138 yards on 11 completions and scoring 3 TDs.
• According to raycarp.com, Arizona's offense posted a 4.3% better success rate and yielded 0.8 more yards per play with Brissett on the field last regular season.
• Las Vegas’ defense struggled through the air a year ago. Per SumerSports, it ranked 23rd with an EPA/pass allowance of 0.08. That number remained the same on late downs, good for 27th.

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Cardinals RB Jeremiyah Love vs. Raiders: 17.5 Rush Yards

• Love’s low projected rushing mark suggests that he’s a member of LaFleur’s celebrated first-string group. With that said, the No. 3 overall NFL Draft pick could still get involved.
• With James Conner still not participating in 11-on-11 drills at Cardinals training camp, that makes for one less mouth to feed in the backfield. 
• In the Cardinals’ first two drives last week, they handed the ball off to a RB eight times, yielding 4.0 yards per touch.
• Love ripped off 39 runs of 10+ yards in his final year at Notre Dame, ranking fourth among halfbacks with 50+ carries. His 52.9% breakaway run rate was 14th. 

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Raiders QB Fernando Mendoza vs. Cardinals: 99.5 Pass Yards

• Kubiak admits that others will still need to be evaluated, but Mendoza “will get plenty of reps” on Thursday in his preseason debut.
• The deep ball was one of Mendoza’s best friends during his championship-winning season at Indiana, seeing him post a 130.1 passer rating (third among QBs with 50+ attempts). 
• Mendoza owned a 5.7% big-time throw rate to close out his college career, tied for 23rd out of 134 players with 200+ dropbacks.
• Don’t worry too much about Mendoza being under constant duress tonight. Per NFL Pro, last year’s Cardinals were 26th in pressure rate (31.6%) and 28th in sack percentage (4.8%) as a defense. 

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All eyes will surely be on Fernando Mendoza as he makes his unofficial NFL debut on Thursday night. Coming off a solid performance in the Hall of Fame Game, could Arizona spoil the night for Las Vegas in its home stadium?

Don’t wait until kickoff for preseason football — make your Cardinals vs. Raiders picks on PrizePicks now and earn real money if you’re right.

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