Cardinals vs. Brewers Prediction, MLB Picks for Wednesday, May 27

The St. Louis Cardinals (29-24) and the Milwaukee Brewers (32-20) cap a three-game series of their NL Central rivalry on Wednesday, May 27, sitting in the early slate with the first pitch scheduled for 1:40 p.m. ET. Milwaukee is a home favorite, returning a 1.63x payout with a win, via PrizePicks Team Picks.

Following back-to-back dominant wins, 5-1 and 6-0, the Brewers are hunting a sweep over the Cardinals on Wednesday afternoon. St. Louis is on a three-game losing streak and is 1-5 in the last six contests.

Below, we'll break down our Cardinals vs. Brewers prediction and picks for Wednesday’s MLB game, including the winner payouts, over/under, and key player picks for PrizePicks.

Make your Cardinals vs. Brewers picks on PrizePicks now for today's MLB matchup.

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Cardinals vs. Brewers Prediction, Winner, Over/Under – Wednesday, May 27

The National League Central is the only division with all teams holding a winning record.

The first-place Brewers have created some wiggle room following two wins over the Cardinals, now sitting 3.5 games above second-place St. Louis. At 29-25, the Reds are in third and four games behind Milwaukee. The Pirates and Cubs are each 29-26 and 4.5 games back from first place. 

According to PrizePicks Team Picks, the Brewers have the shortest payout to win the NL Central (1.81x), while the Cardinals have the highest payout (14.28x).

St. Louis has totaled a measly 2.8 runs per game during its 1-5 stretch over the past six contests. The Cards are sitting around average with 234 runs scored (18th), a .314 wOBA (15th), and 101 wRC+ (tied for 13th), per FanGraphs.

If these struggles at the plate continue, St. Louis is in big trouble, with its pitching holding a 4.89 xERA (29th). The pitching disadvantage may continue today, as Cardinals SP Dustin May will get his 11th start of the season today. He holds a 5.00 ERA and 4.17 xERA through 10 starts.

Milwaukee has yet to announce its starter for today’s series finale. It could be a shared workload between RP Chad Patrick (12 appearances, 5 starts, 4.69 xFIP) and RP Shane Drohan (10 appearances, 1 start, 3.44 xFIP). The Brewers’ bullpen carries a 3.54 xFIP (ninth).

Cardinals vs. Brewers Winner Payout, Over/Under – Wednesday, May 27

The Brewers enter Wednesday’s matchup as a home favorite against the Cardinals, returning a 1.63x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Cardinals vs. Brewers game on PrizePicks.

• Spread: Milwaukee Brewers -1.5 (2.27x payout)
• Over/Under: 8.5 (1.92x payout on Over)
• Game Winner Payout: Cardinals 2.17x | Brewers 1.63x

Make your Cardinals vs. Brewers prediction on the winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!

Team Picks data is live at the time of writing and is subject to change.

Cardinals vs. Brewers Prediction on Spread – 5/27/26

Here are the key game stats and trends behind our Cardinals vs. Brewers prediction on the run line for Wednesday, May 27.

Lock in your Cardinals vs. Brewers prediction on PrizePicks before the first pitch.

• As mentioned, St. Louis has tallied only 2.8 runs per game in the last six games, including only 1 run through two games vs. Milwaukee.
• Racking up 1.13 home runs per game (11th) is one of the Cardinals’ strengths, but the Brewers’ bullpen allows only 0.61 HR/9 (third-lowest). Plus, St. Louis has yet to go yard in this series.
• In five starts from RP Chad Patrick this season, Milwaukee has allowed only 2.4 runs per game in the split.
• If the Brewers lean on RP Shane Drohan, the Cardinals have logged only 61 runs against left-handed pitchers (tied for 20th).
• Cardinals SP Dustin May has allowed at least 2 earned runs in all four starts this month, holding a 4.63 ERA in May.
• According to Baseball Savant, May allows a .259 xBA that ranks in the 28th percentile. The Brewers carry a .249 batting average (sixth) and have posted 10.5 hits per game in this series compared to 8.4 on the season (seventh).

Cardinals vs. Brewers Player Picks, Stats for PrizePicks – 5/27/26

Here are top Cardinals vs. Brewers picks to target on PrizePicks for Wednesday, May 27. Today’s MLB picks for PrizePicks include Dustin May and Jake Bauers.

Cardinals SP Dustin May vs. Brewers: 4.5 Strikeouts

• Dustin May’s been hit or miss in the strikeout category. In fact, he’s totaled 3 Ks in two starts and 7 strikeouts in his other two starts in May.
• Over 10 appearances this season, May has reached 5 Ks in only three outings.
• The Brewers carry a 20.8% strikeout rate (sixth-lowest), and May’s K rate is only 18.3% (24th percentile).
• Most of the right-hander’s success comes from a 30.1% chase rate (48th percentile), but Milwaukee swings at only 28.4% of pitches outside the strike zone (lowest).
• May’s top K rate is held by his sweep (36.5%), with his curveball as his next-best mark (25.0%). The Brewers rake against sweepers, proven by 3.7 runs above average (eighth).

Add Dustin May to your PrizePicks Lineup now.

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Brewers 1B Jake Bauers vs. Cardinals: 4.5 Hitter Fantasy Score

• Dustin May’s most-used pitches are a four-seam fastball (25.7%) and a cutter (22.7%).
• As a team, Milwaukee ranks only 17th and 18th in runs above average against the pitches. However, Jake Bauers could have the answer thanks to his .385 and .444 batting averages against four-seamers and cutters this season.
• Bauers is hitting .339 in May, recording at least 1 hit in 14 of 17 games this month.
• The Cardinals’ starter has permitted a 49.1% hard-hit rate (sixth percentile), and Bauers boasts a 52.5% hard-hit rate (96th percentile).
• St. Louis’ bullpen has a 4.71 xERA (29th) and allows a 35.7% hard-hit rate (fourth-highest).
• In his sole appearance of this series, Bauers racked up a 17-hitter fantasy score.

Add Jake Bauers to your PrizePicks Lineup now.

Make Cardinals vs. Brewers Picks on PrizePicks

After winning the first two games of the series by an average margin of +4.5 runs per game, will the Brewers complete the sweep over their divisional rival on Wednesday? The Cardinals’ bats must wake up against one of the best pitching units in baseball.

Don’t wait until the first pitch — make your Cardinals vs. Brewers picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

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