Brewers vs. Padres Prediction, MLB Picks for Monday, August 10

August 10, 2026

MLB
AP Photo/Lynne Sladky
Brewers C William Contreras strikes out during the sixth inning vs. the Marlins.

Brewers vs. Padres is set for first pitch at 9:40 p.m. ET on Monday, August 10, with the Brewers featuring a 1.78x payout if they win, via PrizePicks.

There's potential for a good pitching matchup in the first game of this series. The Brewers will turn to SP Logan Henderson (6-1, 2.70 ERA), while SP Casey Mize (4-7, 3.40 ERA) will make his second start with the Padres since being acquired in a trade with the Tigers.

Below, we’ll break down our Brewers vs. Padres prediction and picks for Monday’s MLB game, including game winner, over/under, and key player picks for PrizePicks.

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Brewers vs. Padres Prediction, Winner Payout, Over/Under – Monday, August 10

The Brewers should have a significant advantage with their lineup in this series. Per FanGraphs, their 104 wRC+ ranks eighth in baseball. That has propelled them to scoring the fifth-most runs. They aren’t hitting a ton of home runs, but their .324 wOBA ranks sixth in the majors.

The Padres have a winning record despite their offensive shortcomings. Their 96 wRC+ is 20th in baseball and has contributed to scoring the 10th-fewest runs. San Diego bolstered the starting rotation with the additions of Mize and SP Robbie Ray at the trade deadline, but it did not make any significant moves to improve the batting order.


Brewers vs. Padres Winner Payout, Over/Under – Monday, August 10

The Brewers enter Monday’s game as a road favorite against the Padres, returning a 1.78x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Brewers vs. Padres game on PrizePicks Team Picks — where you can make real money predictions on every MLB game!

Win Spread Over/Under
MIL Brewers 1.78x -1.5 | 2.38x o7.5 | 2.0x
SD Padres 1.96x +1.5 | 1.53x u7.5 | 1.75x
Make your Brewers vs. Padres prediction on the spread or over/under on PrizePicks Team Picks — available in 36 states!

Team Picks data is live as of writing and is subject to change.


Brewers vs. Padres Prediction on Winner – Monday, August 10

Here are the key game stats and trends behind our Brewers vs. Padres prediction on the winner for Monday, August 10.

  • At 74-44, the Brewers have the best record in baseball.
  • Milwaukee leads baseball with a +141 run differential. Despite a winning record, the Padres are -10 in that category.
  • While injuries have limited Henderson to 10 starts, he did not allow more than 3 runs in any of those outings.
  • The Padres only have a .672 OPS at home, compared to a .723 OPS on the road.
  • In his first start as a member of the Padres, Mize was roughed up for 8 runs over 3.1 innings against the Diamondbacks. While he posted a 0.90 WHIP in Detroit this year, he has a 1.29 WHIP on the road.
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Brewers vs. Padres Picks, Player Stats for PrizePicks: 8/10/26

Here are top Brewers vs. Padres picks to target on PrizePicks for Monday, August 10. Today's MLB picks for PrizePicks include Logan Henderson and Jake Cronenworth.

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Brewers SP Logan Henderson vs. Padres: 5 Strikeouts

  • Henderson was limited to fewer than 80 pitches in his first two starts off the injured list. In both of those outings, he finished with exactly 4 strikeouts.
  • The young righty has since reeled off three straight games with at least 7 strikeouts. In each of those outings, he hurled at least 80 pitches.
  • Henderson has thrown at least 80 pitches in five of his 10 starts. In all five of those, he posted at least 7 strikeouts.
  • The Padres have the 12th-highest strikeout rate against right-handed pitchers (21.9%).
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Padres 2B Jake Cronenworth vs. Brewers: 5 Hitter Fantasy Score

  • Over his last 10 games, Cronenworth is 9 for 39 (.231) with a .286 OBP and a .256 slugging percentage.
  • The 32-year-old is having the worst season of his career, recording a .274 wOBA and a .068 ISO.
  • A lack of quality contact is one of the reasons for Cronenworth’s decline. He has a minuscule 4.1% barrel rate and a 31.6% hard-hit rate.
  • The second baseman has been even worse at home, posting a .222 wOBA and a .037 ISO in San Diego.
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Make Brewers vs. Padres Picks on PrizePicks

The Brewers will look to improve on their stellar record with a road win over the Padres. They will have Henderson on the mound, who has racked up strikeouts when given an extended pitch count. Henderson could be a tough matchup for Cronenworth, who already comes into the matchup on a cold streak.

Don’t wait until the first pitch — make your Brewers vs. Padres picks on PrizePicks now and earn real money if you’re right.

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Mike Barner has been covering fantasy sports since 2007. He specializes in the NBA, NFL, and MLB. He is a two-time finalist for the Fantasy Sports Writers Association Basketball Writer of the Year award and won the 2021-22 FSGA NBA Experts Champions league. In addition to PrizePicks, Mike has written for Sports Illustrated, RotoWire, SportsLine, and more.