Brentford vs. Tottenham Prediction, Picks, XIs for EPL – Saturday, August 22

Saturday’s EPL match between Brentford and Tottenham is set to kick off at 12:30 p.m. ET Brentford enters the season opener as solid favorites on their home pitch, with a 2.04x payout if they win on PrizePicks.

The Premier League is officially back, and Brentford will look to start the season on the right foot when they host London rivals Tottenham on Saturday afternoon. The Bees failed to win either of their meetings with Spurs last season, losing the first 2-0 and drawing 0-0 in the second.

All eyes will be on Tottenham after a transformative summer in the transfer market. Having narrowly escaped relegation last season, the North London club has committed over £300 million in spending this summer, with more moves potentially still to come.

Below, we'll break down our Brentford vs. Tottenham prediction and picks for Saturday's EPL match, including the Premier League winner payouts, total goals, and top Premier League picks for PrizePicks today.

Make your Brentford vs. Tottenham picks on PrizePicks now!

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Brentford vs. Tottenham Prediction, Picks for EPL – Saturday, August 22

Brentford will attempt to beat Tottenham at home for the first time since 1948. The Bees have been back in the top flight since 2021 but have yet to defeat Spurs at the Brentford Community Stadium.

Given the recent history between these clubs and the money Tottenham has spent recently, Brentford coming into this one as favorites could be a surprised—even at home.

Before today, Brentford had lost or drawn six straight against Spurs, last winning 3-1 back in May 2023. In fact, things have been so difficult for the Bees that they have managed just 1 goal across the last four meetings.

Head coach Keith Andrews will look to put those results behind him and record his first win against Spurs since taking charge in 2025. Andrews was a key figure in Brentford's best Premier League finish of ninth last season, guiding the club to 53 points and a place in the top half of the table.

Brentford were active in the summer transfer window but spent far less than their opponents on Saturday. With roughly £66 million brought in and much of last season's squad retained, the Bees will be hoping to improve on last year's finish and push toward a European qualification spot.

A win over Roberto De Zerbi's Tottenham would go a long way toward those ambitions, though it may prove harder than the payouts suggest.

De Zerbi went 3-2-2 in his seven games in charge at the end of last season and has now been fully backed by the Tottenham board, with the squad he envisioned largely assembled. With so many new faces, it may take time for the group to gel. Even so, Spurs have upgraded in several positions, and picking up at least a point in Saturday's London derby would not be a surprise.

Brentford vs. Tottenham Spread, Total Goals, Payouts – Saturday, August 22

Brentford enters Saturday’s game as home favorites against Tottenham, returning a 2.04x payout if they win outright, via PrizePicks Team Picks.

Meanwhile, Tottenham will look to pull off a notable upset as underdogs on the road, with their 3.03x payout to win.

Here are the full payouts for the Brentford vs. Tottenham game on PrizePicks.

Make your Brentford vs. Tottenham prediction on the spread or total goals on PrizePicks Team Picks to earn real money—available in 36 states!

Team Picks data is live at the time of writing and is subject to change.

Brentford vs. Tottenham Prediction on Total Goals – 8/22/26

Here are the key game stats and trends behind our Brentford vs. Tottenham prediction on total goals for the Premier League match on Saturday, August 22.

Check out more of our EPL picks and predictions on PrizePicks.

• These teams have stayed under 2.5 total goals in three straight meetings heading into Saturday's match.
• Brentford failed to score from 1.21 xG across the two matches against Tottenham last season and have now generated 3.27 xG over their last three meetings against Spurs without finding the net.
• Before last season's second meeting between these clubs, Tottenham had scored in seven consecutive games against Brentford, netting multiple goals in six of those seven outings.
• Brentford ranked sixth among all Premier League clubs in home goals scored last season, finishing with 33 goals scored and just 21 conceded at the Gtech Community Stadium.
• Tottenham were better on both sides of the ball away from Tottenham Hotspur Stadium last season, scoring 4 more goals and conceding 5 fewer on the road in the 2025-26 campaign.

Lock in your Brentford vs. Tottenham prediction on PrizePicks now.

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Brentford vs. Tottenham Projected Lineups

Take a look at the Brentford vs. Tottenham projected lineups for today's EPL match. Lineups are not official and should be confirmed before match start.

Brentford Lineup vs. Tottenham: Projected 4-2-3-1

Goalkeeper: Caoimhin Kelleher

Defense: Michael Kayode, Kristoffer Ajer, Nathan Collins, Keane Lewis-Potter

Midfield: Mathias Jensen, Mamadou Sangare, Vitaly Janelt

Forwards: Dango Ouattara, Igor Thiago, Kevin Schade

Tottenham Lineup vs. Brentford: Projected 4-3-2-1

Goalkeeper: Antonin Kinsky

Defense: Andy Robertson, Jan Paul van Hecke, Marcos Senesi, Archie Gray

Midfield: Conor Gallagher, Sandro Tonali, Antonin Kinsky

Forwards: Mathys Tel, Richarlison, Mikey Moore

Brentford vs. Tottenham Picks, Player Stats for PrizePicks: 8/22/26

Here are Brentford vs. Tottenham picks to target for EPL on PrizePicks for Saturday, August 22. Today’s EPL picks include Igor Thiago and Antonin Kinsky.

Brentford ST Igor Thiago vs. Tottenham: 2 Shots 

• Thiago will look to build on a career season with a strong opener against Tottenham. The Brazilian striker finished second in the Premier League with 22 goals last season.
• He scored 3 goals and added an assist across two preseason appearances heading into the opener, registering 3 shots in 71 minutes in Brentford's final preseason friendly.
• Brentford's No. 9 led the squad with 2.2 total shots per game last season and had more than 2.5 shots in one meetings with Tottenham in 2025-26.

Add Igor Thiago to your PrizePicks Lineup now!

Tottenham GK Antonin Kinsky vs. Brentford: 2.5 Goalie Saves

• Kinsky has nailed down the starting goalkeeper role after some inconsistent performances toward the end of last season. De Zerbi started him in all seven of his games in charge, with the 23-year-old conceding 1.0 goal per game during that stretch.
• The Czech international saved 59% of shots faced last season and had just one game with more than 2.5 saves, averaging 1.4 per game overall.
• Kinsky was featured in three preseason friendlies, surpassing 2.5 saves in just one of those outings. He made no saves across the other two games, playing a total of 119 minutes.

Add Antonin Kinsky to your PrizePicks Lineup now!

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Make Brentford vs. Tottenham Predictions for EPL on PrizePicks

Tottenham will look to open the 2026-27 season with an away upset when they travel to face Brentford on Saturday, August 22. The Bees look to finally get the better of their London rivals and kick off the new campaign with all three points in front of their home supporters.

Don’t wait until kickoff—you can make your Brentford vs. Tottenham picks for Saturday’s EPL match now on PrizePicks and PrizePicks Team Picks to earn real money. 

Just pick your EPL players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on match winner, total goals, and both teams to score—now available in 36 states. 

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