Spain vs. England Prediction, Picks, XIs for UEFA Nations League – Sunday, November 15

Spain and England meet in the UEFA Nations League on Sunday, November 15, at the Metropolitano Stadium in Madrid, Spain, with kickoff set for 2:45 p.m. ET. Spain is favored to win, with a 1.85x payout on PrizePicks, while the underdog England has a 3.33x payout.

Both teams picked up victory on Thursday, and as a result, are qualified for the UEFA Nations League quarterfinals. Spain’s win in the reverse fixture leaves them a heavy favorite to clinch top spot in Group A3, with England needing to win outright to claim the top spot in the group.

To do so would mean ending Spain’s 43-match unbeaten run, stretching back to March of 2024. England has hope, however, as they’ve won nine straight matches on the road. 

Below, we’ll break down our Spain vs. England prediction and picks for Sunday afternoon’s UEFA Nations League match, including the spread, total goals, and key player picks for PrizePicks.

Make your Spain vs. England prediction and UEFA Nations League picks on PrizePicks.

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Spain vs. England Prediction, Winner Payout, Total Goals for UEFA Nations League – Sunday, November 15

Spain enters Sunday’s match as home favorite vs. England, returning a 1.85x payout if they win, via PrizePicks.

Meanwhile, England will look to end Spain’s historic 43-match unbeaten streak, with their 3.33x payout to win outright. PrizePicks has a 3.7x payout for a draw.

Check out today's winner payouts and each squad's payout to win Group A3 for the UEFA Nations League.

PrizePicks data is live at the time of writing and is subject to change.

Make your Spain vs. England prediction on the winner on PrizePicks.

How to watch Spain vs. England: Fubo Sports (English) / ViX (Spanish)

Kickoff Time: 2:45 p.m. ET

Venue: Metropolitano Stadium, Madrid, Spain

Spain’s 3-2 win in the reverse fixture at Wembley could have ended their historic run had Harry Kane capitalized on an early second-half penalty. La Roja would have been down 3-1 despite scoring less than 90 seconds into the match through Lamine Yamal.

Instead, Álex Baena scored the equalizer minutes later, then set up Mikel Oyarzabal for the winner just 16 minutes from time as they completed the remontada to claim all three points and secure their grip on Group A3.

Now they welcome England to Madrid, knowing any positive result would see them claim the top spot in the group. According to PrizePicks, they have a 1.17x payout to finish atop the group at the end of the day. 

Of course, they’ll be looking to win the match outright and extend their 12-match winning streak, dating back to their stunning 0-0 draw with Cabo Verde to open World Cup 2026. They extended that streak with a 2-0 victory over Czechia on Thursday. 

They got a first-half penalty and enjoyed a man advantage for the final 20 minutes before adding a second goal six minutes into stoppage time. It capped off a successful but frustrating affair, given they registered 3.41 xG but put just 5 of 22 shots on target.

Spain will be without AM Dani Olmo for this match, while CM Rodri also is absent from the squad after injuring his hamstring earlier this month. However, Lamine Yamal will be fully available after being kept out of the Czechia match due to a knee issue. 

England’s match on Thursday was a bit more difficult, as they needed a Harry Kane penalty to offset Croatia’s second-half equalizer and hold on for a 2-1 victory. The newly-crowned Ballon d’Or winner became England’s most-capped player in the match, donning the England shirt for the 126th time in his career. 

The Three Lions will wonder what could’ve been had they held on against Spain, as that loss is the only blemish they’ve suffered since the World Cup. They’ve been extremely strong defensively, conceding just 4 goals through the five matches in the group with three clean sheets. 

Should England win, they’d claim the group outright due to superior goal differential. According to PrizePicks, the Three Lions have a 2.94x payout to advance to the quarter-finals as group stage winners. 

England will be without multiple key players, including starting CB Marc Guéhi. RW Bukayo Saka is still recovering from his quad injury suffered last month in Champions League action, but LB Djed Spence is available after missing the Croatia match with a knock. CB Ezri Konsa may also be in contention after missing the Croatia match.

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Spain vs. England Prediction on Winner – 11/15/26

Here are the key game stats and trends behind our Spain vs. England prediction for the match winner for Sunday’s UEFA Nations League match.

Check out more of our Nations League picks and predictions on PrizePicks.

• Spain has not lost a fixture since a March 2024 loss to Colombia in a friendly. Their 43-match unbeaten run has shattered Italy’s previous record of 37 straight matches.
• On Spanish soil, they’ve been nearly unbeatable. Since October 2018, Spain has lost just once in 40 matches inside their borders, winning 31 of those fixtures.
• They’ve also been extremely difficult to beat inside their capital city, going 17-5-0 in their last 22 matches there. However, the last team to win in Madrid was England, taking place in February 1987.
• According to FotMob, Spain’s 4.7 xG conceded is the fewest of the 16 countries participating in Nations League Group A. 
• England’s backline did not look as strong as usual against Croatia, with the CB partnership of a slow Dan Burn and a relatively inexperienced Jarell Quansah. Should Konsa be limited, it would be a massive blow for England against the high-powered Spanish attack that leads Group A with 26 big chances.
• Thomas Tuchel has confirmed that James Trafford will start in goal for England on Sunday over Jordan Pickford, a move designed to get a look at how he’s progressing. However, it will be just Trafford’s fifth cap and leaves them with a huge question mark at the back.

Predict Spain vs. England winner in this Nations League match on PrizePicks.

Spain vs. England Projected Lineups – Sunday, November 15

Here are the projected Spain vs. England lineups for today's UEFA Nations League match. Lineups are not official and are based on historical data and should be confirmed before match start.

Spain Lineup vs. England: Projected 4-2-3-1

• Goalkeeper: Unai Simón
• Defense: Pedro Porro, Pau Cubarsí, Dean Huijsen, Marc Cucurella
• Midfield: Pedri, Fabián Ruiz, Fermín López
• Forwards: Lamine Yamal, Mikel Oyarzabal, Álex Baena

England Lineup vs. Spain: Projected 4-2-3-1

• Goalkeeper: James Trafford
• Defense: Trent Alexander-Arnold, Jarell Quansah, Dan Burn, Lewis Hall
• Midfield: Eliot Anderson, Declan Rice, Jude Bellingham
• Forwards: Morgan Rogers, Harry Kane, Anthony Gordon

Spain vs. England Picks, Player Stats for UEFA Nations League on PrizePicks – 11/15/26

Here are Spain vs. England player picks to target on PrizePicks for Sunday, November 15. Today’s UEFA Nations League picks are headlined by Álex Baena and Anthony Gordon.

Spain LW Álex Baena Pick vs. England: 1.5 Shots Assisted 

• Álex Baena didn’t enter the reverse fixture against England until the 54th minute, but he was extremely influential in his time on the pitch. He scored the equalizer and then set up Mikel Oyarzabal for the winning goal.
• The assist was one of two big chances that Baena created in just 36 minutes on the pitch at Wembley. Now he’s playing on home soil and is expected to start on the left wing, where he will have a favorable matchup against RB Trent Alexander-Arnold.
• According to WhoScored, Baena has registered 8 key passes in his five matches for Spain during this UEFA Nations League run. That comes out to an average of 2.53 per 90 minutes. 
• His most recent outing against Czechia saw him assist 4 shot attempts for teammates, which, along with his penalty goal, saw him named Man of the Match. 
• The Atletico Madrid winger has also assisted multiple shots in nine of his 11 La Liga appearances this season. 

Combine Spain + Álex Baena picks for bigger payouts on PrizePicks.

England LW Anthony Gordon Pick vs. Spain: 3.5 Attempted Dribbles 

• In the first meeting with Spain, Anthony Gordon attempted 6 dribbles over 70 minutes in a matchup with RB Marc Pubill. 
• So far through five UEFA Nations League fixtures, Gordon is averaging 5.13 dribbles per 90 minutes. That’s by far the most in the England squad.
• Gordon plays on the same flank as Lamine Yamal, who will often have possession of the ball for Spain. That means when England wins possession back, he is in a prime spot to get on the ball and run at defenders.
• Spain’s 65.6% possession in the tournament is second only to France. Playing at home, they’ll likely see more of the ball — offering England plenty of opportunities to counter-attack into space. 

Combine England + Anthony Gordon picks for bigger payouts on PrizePicks.

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Make Spain vs. England Picks on PrizePicks

Everything's on the line when UEFA Nations League action kicks off on SUnday. Can Spain continue their historic unbeaten run and take the top spot in Group A3, or will England repeat history and win in Madrid just as they did in their last visit in 1987?

Don’t wait until kickoff — make your Spain vs. England picks for Sunday’s UEFA Nations League match now on PrizePicks and earn real money if you’re right.

Just pick your UEFA Nations League players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on match winners, total goals, and both teams to score — now available in 36 states. 

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