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Week 2 of the 2026 NFL season got started with a bang, as the Buffalo and Detroit Lions combined for 72 points on Thursday Night Football. After witnessing premier players like QB Josh Allen and WR Amon-Ra St. Brown have stellar performances, we’re in for more noteworthy outings around the league.
With plenty of stars in action in Week 2, which players stand out across Sunday’s contests?
Below, we'll bring you our top NFL DFS picks for PrizePicks, where you can predict More or Less on player stats to earn real money!
Stats in this article are courtesy of PFF or SumerSports unless stated otherwise.
Make your Week 2 NFL predictions and picks on PrizePicks!
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Week 2 NFL DFS Picks for PrizePicks – Sunday, September 20
Here are the top Week 2 NFL DFS picks to target on PrizePicks for Sunday, September 20.
Today’s NFL picks include Jordan Love, Chris Olave, Deebo Samuel, George Pickens, and Jacoby Brissett.
Packers QB Jordan Love vs. Jets: 1.5 Pass TDs
- Love has tossed multiple TDs in four of his last six games (including the playoffs), with five of those contests coming on the road.
- In Week 1 against the blitz-heavy Minnesota Vikings, Love threw for 387 yards, 2 TDs, and 1 INT.
- After sitting at 22nd in neutral pass rate (49.7%) in 2025, the Green Bay Packers let Love cook a bit more in their 2026 opener, ranking 13th in neutral pass rate (55.6%), per rbsdm.com.
- Since the start of last season, the New York Jets are 32nd in dropback EPA (0.3) and 22nd in dropback success rate (48.9%).
Pick Jordan Love + Packers to cover the spread on PrizePicks!
Saints WR Chris Olave vs. Ravens: 6 Recs
- Olave exploded for 10 receptions for 182 yards on 13 targets in Week 1 against the Detroit Lions.
- With QB Jacoby Brissett starting since Week 9 of last season for the New Orleans Saints, Olave has accrued 6+ receptions in four straight games.
- After earning the 10th-highest target share (29.4%) among WRs with 100 or more routes run in 2025, Olave had a 25.0% target share in the Saints’ 2026 season opener.
- New Orleans is currently an 8.5-point road underdog on PrizePicks to the Baltimore Ravens in Week 2.
Pick Chris Olave + Saints to cover the spread on PrizePicks!
49ers WR Deebo Samuel vs. Dolphins: 33.5 Rec Yards
- Samuel accrued 48 receiving yards and a score on 6 receptions in Week 1 against the Los Angeles Rams.
- In the win, Samuel was tied with WR Mike Evans for the highest target share (20.6%) among the 49ers’ WRs.
- With rookie WR De’Zhaun Stribling sidelined, Samuel will likely see more snaps in San Francisco’s offense.
- Along with Samuel leading the 49ers in yards per route run (2.53) to begin 2026, the Miami Dolphins are 28th in dropback EPA (0.2) and 31st in dropback success rate (51.9%) allowed since the start of last season.
Pick Deebo Samuel + 49ers to win on PrizePicks!
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Cowboys WR George Pickens vs. Commanders: 62.5 Rec Yards
- Pickens notched at least 78 receiving yards in both meetings against the Washington Commanders in 2025.
- Despite Pickens having only 3 catches for 28 yards in Week 1, he had the seventh-highest average depth of target (aDOT; 18.0) among WRs with at least 5 targets.
- Of the 26 WRs with 100+ targets last year, Pickens had the second-most yards per reception (15.4), sixth-most yards after the catch per reception (5.1), and seventh-most yards per route run (2.4).
- Since the start of 2025, the Commanders are 30th in dropback EPA (0.2) and 26th in dropback success rate (49.6%) allowed.
Pick George Pickens + Cowboys to cover the spread on PrizePicks!
Cardinals QB Jacoby Brissett vs. Seahawks: 34.5 Pass Attempts
- Brissett has made 13 straight starts for the Arizona Cardinals, and he’s attempted 36 or more passes in 10 of them.
- That includes 37 pass attempts in the Cardinals’ Week 1 upset victory over the Los Angeles Chargers.
- No team has a higher neutral pass rate (60.5%) than Arizona since the beginning of last season.
- The Cardinals are currently 3.5-point home underdogs in Week 2 against the Seahawks, a team that Brissett had 44 pass attempts against in Week 10 of last year.
Pick Jacoby Brissett + Cardinals to cover the spread on PrizePicks!
Make Week 2 NFL Picks on PrizePicks
There are endless options to choose from when looking at player projections on PrizePicks in Week 2. Top questions that are left to answer include if Pickens can bounce back after a quiet outing in Week 1 or whether the Packers continue to let Love loose in the passing game.
Ahead of Sunday’s action, it's time to lock in your NFL picks on PrizePicks to win real money if you're right. Just pick your players, predict More or Less on their stats, and cash in on your predictions when you're right.
With PrizePicks Team Picks, make your predictions on game winners, spreads, and over/unders — or combine one with players for even higher payouts.
Stay locked in on Playbook for daily NFL news, picks, and news every day, all the way through Super Bowl LXI.
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