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Week 1 of the college football season didn’t feature many marquee matchups, as teams tend to prefer scheduling easier opponents early to build momentum. However, Week 2 features one of the most anticipated showdowns of the season, with #1 Ohio State taking on #4 Texas.
Aside from the clash of two national championship hopefuls on Saturday, September 12, there are other games that could spawn standout performances.
Below, we'll bring you our top Week 2 CFB DFS picks for PrizePicks, where you can predict More or Less on college football player stats to earn real money!
Make your Week 2 college football predictions and picks on PrizePicks!
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Week 2 CFB DFS Picks for PrizePicks – Saturday, September 12
Here are the top Week 2 CFB DFS picks to target on PrizePicks for Saturday, September 12. Today’s CFB picks include Evan Stewart, Jeremiah Smith, Adam Mohammed, Faizon Brandon, and Rocco Becht.
Oregon WR Evan Stewart vs. Oklahoma State: 45.5 Receiving Yards
- In Oregon’s season opener against Boise State, Stewart tallied 72 yards on 8 receptions.
- Stewart tied teammate WR Jeremiah McClellan for the most targets (9) among the Ducks’ pass catchers vs. the Broncos.
- Tulsa QB Baylor Hayes produced 9.5 yards per attempt in the win over Oklahoma State in Week 1.
- Oregon QB Dante Moore tallied 378 passing yards and 3 passing TDs in the team’s opening game.
- Just last season, Oklahoma State was in the fourth percentile in EPA/pass allowed (0.3) and third percentile in yards per dropbacks allowed (8.5), per Game on Paper.
Add Evan Stewart to your PrizePicks lineup now!
Ohio State WR Jeremiah Smith vs. Texas: 6 Receptions
- Even with Texas limiting Smith to 43 yards in its meeting against Ohio State last season, he still brought in 6 catches.
- Smith started the 2026 campaign with a bang, hauling in 8 of his 9 targets for 151 yards and 2 TDs against Ball State.
- Among QBs with 20-plus dropbacks so far this year, Ohio State QB Julian Sayin has the ninth-highest adjusted completion percentage (88.0%), per PFF.
- Across his 13 games in 2025, Smith accrued at least 6 receptions in nine of them.
Add Jeremiah Smith to your PrizePicks lineup now!
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California RB Adam Mohammed vs. Syracuse: 87.5 Rush Yards
- During California’s season opener against UCLA, it deployed Mohammed as a workhorse, giving him 28 of the team’s 34 carries by running backs.
- In those 28 rushing attempts, Mohammed scampered for 120 yards and a TD.
- While Mohammed transferred from Washington to Cal this season, he finished last year with at least 105 rushing yards in two of his final three games.
- Last season, Syracuse was 134th out of 136 schools in yards per rushing attempt allowed (6.2), while also ranking in the 21st percentile in rush EPA/play allowed (0.15).
Add Adam Mohammed to your PrizePicks lineup now!
Tennessee QB Faizon Brandon vs. Georgia Tech: 236.5 Pass Yards
- Faizon got his collegiate career started against Furman in Week 1, throwing for 223 passing yards and 3 passing TDs in a 56-9 victory.
- In the win over Furman, Faizon only needed 17 pass attempts to achieve his passing output.
- Georgia Tech was in the 14th percentile in EPA/pass (0.23) and 28th percentile in yards per dropback (7.1) allowed in 2025.
- The Yellow Jackets also resided in the ninth percentile in early-down EPA/play (0.17) and 35th percentile in late-down success rate (48.0%).
Add Faizon Brandon to your PrizePicks lineup now!
Penn State QB Rocco Becht vs. Temple: 221.5 Pass Yards
- Against Marshall in his Penn State debut, Becht registered 271 passing yards and 4 passing TDs.
- While Becht didn’t finish strong with Iowa State last season, he threw for at least 243 yards in five of his first eight starts.
- Of the quarterbacks with 15 or more dropbacks this season, Becht has the most yards per attempt (15.9).
- Temple was in the ninth percentile in yards per dropback (8.0) and 33rd percentile in EPA/pass (0.14) last season.
Add Rocco Becht to your PrizePicks lineup now!
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Make Week 2 College Football Picks on PrizePicks
There are a handful of enticing games taking place in Week 2 of the college football season, but none are bigger than #1 Ohio State facing #4 Texas. Besides Jeremiah Smith, which players are worth watching on Saturday?
Ahead of today’s action, it's time to lock in your CFB picks on PrizePicks to win real money if you're right. Just pick your players, predict More or Less on their stats, and cash in on your predictions when you're right.
With PrizePicks Team Picks, make your predictions on game winners, spreads, and over/unders — or combine one with players for even higher payouts.
Stay locked in on Playbook for daily college football predictions, picks, and news every day, all the way through the National Championship.
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