Quarterback injuries led to some quiet scoring performances during Week 9. That included the Arizona Cardinals and Seattle Seahawks game that resulted in a 17-3 Seattle win with both teams starting a backup under center.
Factoring in injuries and moves made at the trade deadline, what matchups stand out this week?
Below, we’ll examine the schedule and discuss our best Week 10 NFL predictions, including picks for winners, spreads, over/unders, team totals, and more on PrizePicks.
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New England Patriots vs. Detroit Lions Prediction on Spread for NFL Week 10
Time + How to Watch: 9:30 a.m. ET on FOX
The Patriots were picked apart by the Packers last week, losing 45-27 at home. QB Drake Maye is healthy, but teammates are dropping around him.
RB TreVeyon Henderson (illness) has been ruled out, while RB Rhamondre Stevenson (knee) is also expected to miss a few weeks. He wasn't in uniform for Friday’s practice.
New England’s offensive line is an issue, too. G Alijah Vera-Tucker (hamstring), G Mike Onwenu (ankle), and G Greg Van Roten (hamstring) are all on IR. G Ben Brown (knee) is also out for Week 10, meaning their depth at guard will be about as thin as it gets.
The Lions are improving on the health front, specifically since the return of S Brian Branch from IR. In their first five games without him, they allowed an average of 29.6 points. Across three games with him on the field, they surrendered an average of 13.7 points.
That included holding the Packers to 17 points in Week 7. WR Amon-Ra St. Brown is questionable with a rib injury, but he was in that same boat heading into last week’s game and played.
This contest being played in Germany doesn’t leave a home-field advantage for either side.
The Lions are tied for the third-most sacks (27) in the NFL, so they could exploit the lack of talent at guard for New England. This sounds strange to say given all the talent that they have on offense, but it might be the Lions’ defense that's the difference in this matchup.
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San Francisco 49ers vs. Dallas Cowboys Prediction on Spread for NFL Week 10
Time + How to Watch: 4:25 p.m. ET on FOX
The 49ers continue to win despite injuries plaguing their roster. They knocked off the Raiders last week, securing a 38-17 outcome at home. Leading up to Week 10, they bolstered their WR room by acquiring Keenan Allen in a trade with the Colts.
WR Mike Evans (Achilles) isn’t expected to be ready to return this week, but Deebo Samuel (hamstring) is trending in the right direction after having returned to practice on a limited basis.
Even with all the injuries on offense, the 49ers average 29.4 PPG. QB Brock Purdy has been excellent, throwing for 1,980 yards and 17 TDs through eight games. He also completes 69.1% of his pass attempts.
Look for Purdy to potentially exploit a Cowboys defense that's 28th in dropback EPA/play allowed, according to RBSDM.
The Cowboys are 1-2 in Dallas, with their last home win coming in Week 2 against the Commanders. Their most embarrassing home loss was a 33-30 overtime defeat at the hands of the Cardinals in Week 8. They defeated the Colts in Indianapolis last week, but their defense gave up 23 points along the way.
The 49ers could score at will here, so things may get out of hand for Dallas in a hurry.
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Buffalo Bills vs. New York Jets Prediction on Over/Under for NFL Week 10
Time + How to Watch: 1 p.m. ET on CBS
The Bills have won four straight games, with the victories coming in very different fashions. They produced a 37-34 overtime win over the Rams in Week 5, then followed up with a close 33-30 win over the Raiders in Week 6.
Following their Week 7 bye, they knocked off the Ravens and Vikings by a combined 43 points. In those two games, they allowed a total of only 16 points.
Buffalo scored a season-low 23 points against the Vikings last week. That’s actually an accomplishment, considering that Minnesota only allows 14.5 PPG. For the season, the Bills lead the NFL with their 32.0 PPG mark.
Don’t read too much into the Bills’ defense playing well the last two weeks. The Ravens had third-string QB Joe Fagnano under center for most of their game, and the Vikings rolled with backup QB Carson Wentz.
This matchup between the Bills and Jets comes with plenty of offensive firepower on both sides and two teams that also don’t play much defense. The Jets are 30th in dropback EPA/play allowed, which has contributed to them allowing 24.8 PPG.
In each of their last four games, they allowed a minimum of 26 points. There’s a path for the Bills to scoring 30+ points in this one.
With regards to the Jets’ offense, star WR Garrett Wilson has already returned to practice on a limited basis after sitting out last week with a concussion. Jets head coach Aaron Glenn believes that Wilson will clear the final step of the concussion protocol by Sunday.
In the two games this season that he, WR Omar Cooper Jr., and WR Adonai Mitchell all played together, the Jets scored 25 and 33 points. If the Jets need to throw a lot to keep up with Buffalo’s offense, they have the firepower to be productive.
Make your Bills vs. Jets prediction for NFL Week 10 on PrizePicks.
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Injuries on the Patriots might make it difficult for them to keep their Week 10 matchup against the Lions close. The 49ers look to continue their dominance when they face the Cowboys, who haven't played well at home. Elsewhere, in the AFC East showdown between the Bills and Jets, both offenses could shine.
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