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Week 1 of the 2026 NFL season has begun with the rematch of Super Bowl LX between the New England Patriots and Seattle Seahawks on Wednesday, followed by the San Francisco 49ers and Los Angeles Rams squaring off on Thursday. Ahead of Sunday’s slate of games, there are an abundance of favorable matchups to target on PrizePicks.
With plenty of stars in action in Week 1, which players stand out across Sunday’s contests?
Below, we'll bring you our top NFL DFS picks for PrizePicks, where you can predict More or Less on player stats to earn real money!
Make your Week 1 NFL predictions and picks on PrizePicks!
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Best NFL DFS Picks in Week 1 for PrizePicks – Sunday, September 13
Here are the top Week 1 NFL DFS picks to target on PrizePicks player picks for Sunday, September 13. Today’s NFL picks include Amon-Ra St. Brown, Bucky Irving, Luther Burden III, Parker Washington, and Tyler Shough.
Lions WR Amon-Ra St. Brown vs. Saints: 6.5 Receptions
- Of the WRs who ran 250 or more routes in 2025, St. Brown had the third-highest target share (31.3%).
- St. Brown averaged 7.1 receptions per game when playing indoors, compared to 6.6 receptions per game when playing outdoors last season, per Pro Football Reference.
- The Detroit Lions will be at home against the New Orleans Saints as 6.5-point favorites in Week 1.
- Across the 16 games he started and finished last year, St. Brown posted 7 or more receptions in 10 of them.
Add Amon-Ra St. Brown to your PrizePicks lineup now!
Buccaneers RB Bucky Irving vs. Bengals: 14.5 Rush Attempts
- Although Irving dealt with injuries in 2025, he earned 15 or more rushing attempts in 8 of his 10 starts.
- RB Rachaad White is no longer on the Tampa Bay Buccaneers, and RB Kenneth Gainwell figures to have a receiving role more than a consistent role on the ground.
- A way for the Buccaneers to combat the offensive firepower of the Cincinnati Bengals is to pound the rock and keep QB Joe Burrow off the field.
- The Bengals were 26th in defensive rushing success rate (43.5%) last year, per RBSDM, though they’ve added DT Dexter Lawrence to their defensive front.
Add Bucky Irving to your PrizePicks lineup now!
Bears WR Luther Burden III vs. Panthers: 57.5 Receiving Yards
- Only WR Puka Nacua and WR Jaxon Smith-Njigba had more yards per route run than Burden (2.69) among WRs with 50 or more targets in 2025, via Sumer Sports.
- Additionally, Burden had the third-most yards after the catch per reception (7.3) in the same sample.
- Burden accrued 67 or more receiving yards in three of his final four regular-season outings last season.
- Besides WR DJ Moore no longer being on the Chicago Bears, WR Rome Odunze holds a questionable tag for Sunday’s game with a calf injury.
Add Luther Burden III to your PrizePicks lineup now!
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Jaguars WR Parker Washington vs. Browns: 4 Receptions
- Washington became a trusted target for QB Trevor Lawrence last season, logging the 21st-most targets per route run (0.23) among WRs with at least 250 routes run.
- Lawrence’s pass completions projection on PrizePicks is sitting at 20.5.
- In Washington’s last five games in 2025 (including the playoffs), he had 5 or more receptions in four of them.
- While the Cleveland Browns had the eighth-lowest dropback success rate allowed (43.4%) last season, defensive coordinator Jim Schwartz is no longer calling the shots, and All-Pro EDGE Myles Garrett is on the Los Angeles Rams.
Add Parker Washington to your PrizePicks lineup now!
Saints QB Tyler Shough vs. Lions: 33 Pass Attempts
- Even with the New Orleans Saints being a bit cautious when first starting Shough last season, he averaged 32.8 pass attempts per game across his nine starts.
- New Orleans let Shough loose to end the year, as he tallied 35 or more pass attempts in four of his last seven starts.
- The Saints are nearly touchdown underdogs on the road against the Lions, likely leading to more passing opportunities for Shough.
- From Week 9 to Week 18 with Shough as the starting QB last year, New Orleans was ninth in neutral pass rate (54.2%).
Add Tyler Shough to your PrizePicks lineup now!
Make Week 1 NFL Picks on PrizePicks
The impending Week 1 matchup between the Lions and Saints figures to be a high-scoring affair that leads to notable performances from multiple players. Which other player picks are worth taking on PrizePicks for Sunday’s games?
Ahead of today’s action, it's time to lock in your NFL picks on PrizePicks to win real money if you're right. Just pick your players, predict More or Less on their stats, and cash in on your predictions when you're right.
With PrizePicks Team Picks, make your predictions on game winners, spreads, and over/unders — or combine one with players for even higher payouts.
Stay locked in on Playbook for daily NFL news, picks, and news every day, all the way through Super Bowl LXI.
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