Best NFL Anytime Touchdown Scorer Predictions for Week 2 – Saquon Barkley, More

As expected, the Detroit Lions and Buffalo Bills managed to put plenty of points on the board on Thursday Night Football. With the rest of the NFL Week 2 slate on the horizon, could a similar trend follow?

Some high-flying offenses will soon take the field, packing each window of games with tons of upside. Whether you’re tapping in for early-afternoon outings, a late game or one of Sunday Night Football or Monday Night Football, you’re likely to see someone cross into the end zone at least a time or two. 

Below, we'll highlight our best NFL Anytime TD scorer predictions for PrizePicks in NFL Week 2, including five players who could reach the end zone.

Make your NFL Anytime TD picks for Week 2 on PrizePicks now.

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Best Week 2 NFL Anytime TD Scorer Picks for PrizePicks

From the first kickoff of the day until Colts vs. Chiefs or Giants vs. Rams in prime time, teams will aim to follow up what was a historically productive Week 1 scoring output. If offense is back in style, that’s good news for touchdown scorer picks.

Anytime TDs on PrizePicks include rushing, receiving, recoveries, and returns. PrizePicks often list Anytime TDs as Demons and Goblins, meaning users can only select "More." For standard projections, users can select “More” or “Less.”

Demons are tougher to win but are the only way to get higher payouts. Meanwhile, Goblins are lower than a standard projection, but they are easier to win, so there’s a lower payout.

Here are the top NFL Week 2 Anytime TD scorer picks to target this weekend, headlined by RBs Saquon Barkley, Javonte Williams, and Kenneth Walker III. 

Eagles vs. Titans Anytime TD Scorer Prediction – 1 p.m. ET

Eagles RB Saquon Barkley: 0.5 Anytime TDs

• While the Eagles’ offensive line certainly needs to do its part, Barkley is holding up his end of the bargain. The star halfback had 78 of his 83 Week 1 rushing yards after contact.
• The former Penn State standout’s 5.2 yards after contact per attempt vs. the Commanders marked the third-best output of his tenure with the team. 
• Barkley has established quite the volume floor, averaging just under 334 touches per season from 2022-2025 and notching 4.9 yards per touch. He had 44 TDs in that span.
• Philadelphia had a -5.9% pass rate over expected in Week 1, the 10th-lowest figure in the sport per nfelo.
• Tennessee allowed New York Jets RB Breece Hall to amass 102 yards and a TD on 22 carries last week.  

Add Saquon Barkley + Eagles to cover the spread to your PrizePicks lineup now.

Steelers vs. Patriots Anytime TD Scorer Prediction – 1 p.m. ET

Patriots TE Hunter Henry: 0.5 Anytime TDs (Demon)

• With RB Rhamondre Stevenson struggling in Week 1 and TreVeyon Henderson potentially being eased in as he makes his 2026 debut, New England could rely more on the passing game. 
• The absence of star WR A.J. Brown (ankle) also adds incentive for Henry, who combined for 184 targets across 2024 and 2025, to continue being fed the ball. 
• Per Sharp Football Analysis, Patriots RBs failed to produce positive yardage on 29.2% of their carries to open the year, the lowest mark in the sport. 
• Some of Henry’s best production has come against the Steelers. In four career games vs. Pittsburgh, he’s snapped for 19 receptions on 24 targets for 230 yards and 6 TDs.
• The Steelers were football’s fourth-worst defense against TEs in 2025, surrendering 106 catches, 1,121 yards, 11 TDs, and 176.3 fantasy points. 

Add Hunter Henry + Patriots to win to your PrizePicks lineup now.

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Commanders vs. Cowboys Anytime TD Scorer Prediction – 4:25 p.m. ET

Cowboys RB Javonte Williams: 0.5 Anytime TDs (Goblin)

• Williams found the end zone twice in the Cowboys’ regular-season opener against the New York Giants, factoring into the game both on the ground and through the air.
• The star RB is coming off the best campaign of his career, which saw him log personal bests for rushing yards (1,201), TDs (11), and success rate (56.3%). 
• According to RBSDM, last year’s Commanders surrendered 0.026 rush EPA/play, the fifth-highest output in the league.
• Washington was hit for a whopping 20 TDs by the RB position in 2025.
• Williams is an elusive rushing threat; he averaged 3.56 yards after contact per attempt last season and forced 54 missed tackles, via Pro Football Focus. 

Add Javonte Williams + Cowboys to cover the spread to your PrizePicks lineup now.

Colts vs. Chiefs Anytime TD Scorer Prediction – Sunday Night Football

Chiefs RB Kenneth Walker III: 0.5 Anytime TDs (Goblin)

• In Week 1’s win over the Denver Broncos, the Chiefs had their third-most rushing yards (220) of the Andy Reid era, which dates back to 2013.
• K.C. seems committed to a new-look ground game, as Walker had the most rushing yards from under center for a Chief in the last decade.
• Even on just 68% of snaps vs. Denver, Walker was able to log a staggering 26 touches. 
• Indianapolis struggled vs. the run in Week 1, ceding 0.101 EPA/play in an outing that ranked 26th in the sport. 
• QB Patrick Mahomes made an effort to involve his halfbacks in the passing game to begin the season. Out of his 27 attempts, 8 went to RBs, and 33.7% of his yards stemmed from that room. 

Add Kenneth Walker III + Chiefs to win to your PrizePicks lineup now.

Giants vs. Rams Anytime TD Scorer Prediction – Monday Night Football

Rams RB Kyren Williams: 0.5 Anytime TDs (Goblin)

• Williams was heavily included in the Rams’ red-zone plans to kick off the 2026-27 season, logging 57.1% of their carries inside the 20 and 75.0% inside the 10.
• Only four teams (Jets, Bengals, Cardinals, Commanders) afforded more fantasy points to RBs than the 2025 Giants.
• L.A. went totally against its norms vs. the San Francisco 49ers in Melbourne, posting the lowest pass rate over expected (-17.3%) in the NFL. 
• Keeping with that theme, head coach Sean McVay opted for 13 personnel (one running back, three TEs) on 36.8% of snaps after leading the sport at 30.5% in 2025, via NFL Pro.
• New York yielded a 48.3% offensive success rate to Dallas last Sunday night, slotting in 23rd leaguewide. 

Add Kyren Williams + Rams to cover the spread to your PrizePicks lineup now.

Make NFL Week 2 Picks on PrizePicks

Based on matchups and recent performance, this group of five players might just rise to the occasion and reach pay dirt by the time Week 2 comes to a close. If you have someone else in mind for your Anytime TD scorer picks, PrizePicks has you covered there as well. 

Don’t wait until kickoff — make your NFL Week 2 picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats (like Anytime TDs), and cash in if you’re right. With Team Picks, you can make predictions on NFL game winners, spreads, and over/unders, now available in 36 states.

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