Best NFL Anytime TD Scorer Predictions for Week 5: Amon-Ra St. Brown, More

The Week 5 NFL slate is the first of the year that sees multiple teams on bye, but the show must go on. Fortunately for football fans, there are several star-studded and potentially lopsided matchups that might leave the door wide open for touchdowns. 

Whether it’s Sunday morning’s London game between the Philadelphia Eagles and Jacksonville Jaguars, the Buffalo Bills vs. Los Angeles Rams clash on Monday Night Football or anything in between, there’s bound to be a wide variety of players finding pay dirt. From high-scoring offenses and household names to unsung heroes, PrizePicks boasts no shortage of options.

Below, we'll highlight our best NFL Anytime TD scorer predictions for PrizePicks in NFL Week 5, including five players who could reach the end zone.

Make your NFL Anytime TD picks for Week 5 on PrizePicks now.

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Best Week 5 NFL Anytime TD Scorer Picks for PrizePicks

Both the early- and late-afternoon windows present juicy matchups that may see an excess of points put up on the scoreboard. In prime time, even the injury-riddled Baltimore Ravens could see a score or two against a resurgent Atlanta Falcons crew. 

Elsewhere, a clash of titans on MNF might just turn out to be the best game of the week. Who helps their team to victory in Week 5?

Anytime TDs on PrizePicks include rushing, receiving, recoveries, and returns. PrizePicks often list Anytime TDs as Demons and Goblins, meaning users can only select "More." For standard projections, users can select “More” or “Less.”

Demons are tougher to win but are the only way to get higher payouts. Meanwhile, Goblins are lower than a standard projection, but they are easier to win, so there’s a lower payout.

Here are the top NFL Week 5 Anytime TD scorer picks to target this weekend, headlined by WR Nico Collins, RB Aaron Jones, and WR Puka Nacua. 

Texans vs. Titans Anytime TD Scorer Prediction – 1 p.m. ET

Texans WR Nico Collins: 0.5 Anytime TDs (Demon)

• Collins returned with a loud Week 4 performance, hauling in 7 passes on 8 targets for 118 yards and a pair of TDs. 
• Via SumerSports, Collins sits seventh among all NFL WRs with a 28.57% target share on offense.
• While it’s only been a two-game sample size, Collins is producing a career-best 61.1% success rate and a 150.9 passer rating when targeted. 
• Per NFL Pro, Collins ranks in the top five for wideouts with 3.66 fantasy points per reception and 2.85 per target, both tops for his Texans tenure.
• Tennessee enters Week 5 ranked 26th in team dropback EPA/play allowed with 0.197. 

Add Nico Collins + Texans to cover the spread to your PrizePicks lineup now.

Vikings vs. Saints Anytime TD Scorer Prediction – 1 p.m. ET

Vikings RB Aaron Jones: 0.5 Anytime TDs

• Jones has logged 22+ touches in three consecutive weeks and also got a 73% snap share in Week 4.
• After going catchless in Weeks 1 and 2, Jones’ totals were 5 and 4 over the next two weeks on 6 and 7 targets, respectively. 
• Jones’ breakaway run rate of 23.2% is his best since 2023 in his final season with the Green Bay Packers.
• No defense has surrendered more fantasy points to RBs than the Saints at 117.0, fueled by an NFL-high 9 rushing TDs ceded to the position.
• According to RBSDM, New Orleans’ rush defense is dead last in EPA/play (0.081) and success rate (52.7%). 

Add Aaron Jones + Vikings to win to your PrizePicks lineup now.

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Lions vs. Cardinals Anytime TD Scorer Prediction – 4:25 p.m. ET

Lions WR Amon-Ra St. Brown: 0.5 Anytime TDs (Goblin)

• St. Brown is off to a lava-hot start in 2026, logging double-digit targets in three of four games and going for 5 TDs overall. 
• ARSB sits sixth at the WR position in target share (28.93%) while also being 13th in targets per route run (0.28). 
• Pro Football Focus shows that QB Jared Goff and St. Brown have connected to the tune of a 128.2 passer rating and 0.24 EPA/play. 
• Arizona is a downright dreadful passing defense, slotting in at 31st in EPA/dropback (0.346) and 25th in dropback success rate (49.6%). 
• The Cardinals have seen a WR score on them a league-worst 8 times in 2026, also allowing them to rack up 667 receiving yards on just 37 receptions (tied for fifth-least).

Add Amon-Ra St. Brown + Lions to cover the spread to your PrizePicks lineup now.

Ravens vs. Falcons Anytime TD Scorer Prediction – Sunday Night Football

Falcons RB Bijan Robinson: 0.5 Anytime TDs (Goblin)

• Robinson is enjoying a legendary season thus far, scoring 5 TDs and amassing 614 scrimmage yards in the process.
• Bijan’s taken his rushing production to a new level, leading the sport with 26 first downs on the ground and upping his per-game yardage from 86.9 in 2025 to 123.5 in 2026.
• Via nfelo, Atlanta has football’s lowest pass rate over expected (-11.0%) through four games, fueled by a 54% rush rate that tops all teams. 
• Robinson’s 19.35% target share trails only Christian McCaffrey of the San Francisco 49ers (20.0%) and R.J. Harvey of the Denver Broncos (21.88%). 
• Courtesy of Sharp Football Analysis, Robinson nets 5.2 yards per carry and a 13% explosive run rate against sub-packages. Baltimore plays in sub-packages at the third-highest rate vs. the run (84.0%), ceding a 12.9% clip of 10+ yard runs.

Add Bijan Robinson + Falcons to win to your PrizePicks lineup now.

Bills vs. Rams Anytime TD Scorer Prediction – Monday Night Football

Rams WR Puka Nacua: 0.5 Anytime TDs

• Much like Collins, Nacua returned from injury last week and put together a gaudy stat line (9 catches on 12 targets for 125 yards). 
• When Nacua last squared off against the Bills in Week 14 of the 2024 campaign, he detonated for 12 receptions on 14 targets for 162 yards and a TD. 
• Out of 105 wideouts with 50+ routes run this year, Nacua’s sitting sixth with a yards per route run figure of 2.88. 
• It’s worth noting that while he doesn’t have a designation for game day, Bills CB Christian Benford (toe) is banged up. Fellow CB Dee Alford (ankle) is questionable.
• Buffalo has already given up the sixth-most receiving yards (744) to the WR spot while also allowing 6 TDs.  

Add Puka Nacua + Rams to cover the spread to your PrizePicks lineup now.

Make NFL Week 5 Picks on PrizePicks

Dozens of different players may cross into the end zone on Sunday and Monday, but this group of five very well could rise to the top. If you have one of these players in mind or are looking to make other TD scorer predictions, PrizePicks has you covered.

Don’t wait until kickoff — make your NFL Week 5 picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats (like Anytime TDs), and cash in if you’re right. With Team Picks, you can make predictions on NFL game winners, spreads, and over/unders, now available in 36 states.

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