The regular season ends in under two weeks, and many playoff spots are still up for grabs. In the American League, no division lead exceeds 3.5 games, and in the AL Wild Card race, there are six teams within 6.0 games of the final spot.
Today features a full schedule of 15 games on the MLB schedule, meaning plenty of opportunities for players to make a difference with home runs as the playoff chase marches on.
Here at PrizePicks, we have a wide range of home run projections to add to your MLB picks today. Many hitters have already been singled out by users as popular home run picks for the day’s action.
Let’s dive into some of the most-picked MLB home run projections for Tuesday, September 15, including what gives each player a great opportunity to send a ball into the bleachers.
Make your MLB home run picks on PrizePicks now.
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Best MLB Home Run Picks Today – Tuesday, September 15
The King of Swing resides in Philadelphia as Phillies DH Kyle Schwarber leads the league with 44 home runs. Chicago Cubs CF Pete Crow-Armstrong is not far behind with 42 home runs, and Rays 3B Junior Caminero has 40.
While those are the top players, there are many others whose bats are red-hot and can get one out at any time.
When analyzing potential home runs, it’s more than just the hitter. Opposing pitchers, ballpark dimensions, and weather are all factors in identifying the optimal home run pick.
Which players could be in good positions to crush a homer on Tuesday? Daily home run projections are listed as Demons on PrizePicks, coming with higher payouts as a result. Home runs can only be selected as “More” than 0.5.
Let’s take a look at the most popular home run picks today on PrizePicks. Picks are listed at the time of writing.
- Phillies DH Kyle Schwarber
- Cubs CF Pete Crow-Armstrong
- Rays 3B Junior Caminero
- Orioles 1B Pete Alonso
- White Sox 1B QMunetaka Murakami
- Astros DH Yordan Alvarez
- Reds SS Elly De La Cruz
- Cardinals RF Jordan Walker
Three home run picks stand out as potential targets today. Let’s dive into the list, including a weather report from RotoGrinders.
Unless otherwise noted, data used in this article is from Baseball Savant or FanGraphs.
Rays 3B Junior Caminero
Athletics vs. Rays – 6:40 p.m. ET
Athletics Starting Pitcher: Jack Perkins
MLB Weather Report: Matchup in a dome.
- Caminero has established himself as one of the league's top power hitters. After crushing 45 home runs in 2025, he currently has an American League-leading 40.
- His ability to send a souvenir into the stands is likely due to the combination of his hard-hit rate (49.8%, 91st percentile), barrel rate (13.0%, 87th percentile), and bat speed (79.6 mph, 100th percentile).
- Perkins is prone to giving up the long ball, allowing a home run in 13 of his last 17 appearances.
- Caminero has enjoyed more success with the long ball at Tropicana Field, posting a 26.3% HR/FB rate compared with a 23.5% on the road.
Add Junior Caminero to your PrizePicks lineup now.
Orioles 1B Pete Alonso
Orioles vs. Mets – 7:10 p.m. ET
Mets Starting Pitcher: Sean Manea
MLB Weather Report: 67 degrees, 0% chance of rain, 6 mph west-southeast wind
- After seven seasons in New York, Alonso returns to Citi Field for the first time since leaving the Mets in the offseason.
- The Orioles’ first baseman has delivered consistent power throughout his career, with 30+ home runs in every full MLB season.
- Alonso is 1 for 2 with a home run in head-to-head matchups with Mets SP Sean Manaea.
- The former Met holds the most career home runs at Citi Field (85).
Add Pete Alonso to your PrizePicks lineup now.
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Giants DH Rafael Devers
Giants vs. Cardinals – 7:45 p.m. ET
Cardinals Starting Pitcher: Andre Pallante
MLB Weather Report: 92 degrees, 64% chance of rain, 6 mph west-southeast wind
- Devers has shined in San Francisco this season, and his 37 home runs are one shy of tying his single-season high.
- He’s been one of the top power hitters in the league, leading the league in home runs (8) and ranking second in HR/FB rate (57.1%) since August 31.
- Pallante has struggled to prevent the long ball against left-handed hitters, with a 9.2% HR/FB rate compared with 7.4% for right-handed hitters.
- Devers has shown off his power at Busch Stadium, hitting 4 home runs in six games.
Add Rafael Devers to your PrizePicks lineup now.
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With 15 games on the schedule, there are plenty of opportunities to choose players who will go yard. Three players with 40 or more home runs, including Junior Caminero, have an excellent chance to hit one tonight.
Don’t wait until first pitch — make your MLB home run picks on PrizePicks now and earn real money if you’re right.
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