After some thrilling matchups beginning on Thursday night and lasting well into the weekend, the NFL’s Week 6 slate comes to its official close with the arrival of Monday Night Football between the Washington Commanders and San Francisco 49ers (8:15 p.m. ET, ABC & ESPN).
With Washington’s QB situation stabilizing for the time being and San Francisco’s offense continuing to produce some of the best results in the sport, there could be some points scored in this one. PrizePicks agrees, with the over/under being set at 51.5 points. Which stars might get on the board by way of touchdown on Monday?
Below, we'll highlight our best Commanders vs. 49ers Anytime TD scorer predictions for Monday Night Football, including three players who could reach the end zone.
Make your Commanders vs. 49ers Anytime TD scorer picks on PrizePicks now.
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Commanders vs. 49ers Anytime TD Scorer Picks for Monday Night Football – October 19
It’s been a roller coaster of a season for the Commanders thus far, as they’re 1-3-1 on the year and rank in the middle of the pack (17th) with an average of 23.0 points per game. The inconsistent availability of QB Jayden Daniels hasn’t helped, but the former #2 overall pick put up a nice performance in Week 5 with a 91.9 passer rating and 2 total TDs.
RB Jacory Croskey-Merritt (groin) is out for Week 6, whereas WR Stefon Diggs (hamstring) is questionable. Either way, this is an attack that is much more potent when Daniels is playing the same freed-up brand of football he’s working back to.
On the other sideline, even with a revolving cast of characters each week, the 49ers have constructed an offense with an immensely high floor and ceiling. Head coach Kyle Shanahan’s crew ranks fourth and eighth in points and yards per drive, also converting on third downs at a 51.9% clip that tops all NFL teams.
With QB Brock Purdy slinging the rock, RB Christian McCaffrey remaining a multifaceted threat, and TE George Kittle looking more like his pre-injury self, this offense has enough talent to get the job done most weeks. Don’t let WR Mike Evans’ status (ribs/Achilles, questionable) scare you.
That said, who finds their way into the end zone in Week 6’s finale?
Anytime TDs on PrizePicks include rushing, receiving, recoveries, and returns. PrizePicks often list Anytime TDs as Demons and Goblins, meaning users can only select "More." For standard projections, users can select “More” or “Less.”
Demons are tougher to win but are the only way to get higher payouts. Meanwhile, Goblins are lower than a standard projection, but they are easier to win, so there’s a lower payout.
Commanders WR Terry McLaurin vs. 49ers: 0.5 Anytime TDs (Demon)
- After a slow start and some low volume in his first two games, Terry McLaurin has come alive. In his last two contests, he’s averaged 6.5 targets, 5 receptions, and 69.5 yards.
- The veteran wideout is producing 4.9 yards after catch per reception, his highest total since 2022 (5.1), when he made his first Pro Bowl.
- According to Pro Football Focus, the Daniels-to-McLaurin connection has produced 0.55 EPA/play on the year.
- Scary Terry resides just inside the top 30 WRs in target share at 22.3%, even with Diggs (24.0%, 22nd) splitting the field with him, via SumerSports.
- San Francisco’s defense is dominant against the run, ranking second in lowest EPA/carry (-0.215) allowed. It’s a bit more forgiving vs. the pass, slotting in at 13th in EPA/dropback (0.018).
Add Terry McLaurin + Commanders to win to your PrizePicks lineup now.
49ers RB Christian McCaffrey vs. Commanders: 0.5 Anytime TDs (Goblin)
- Christian McCaffrey has racked up 5 TDs in his last four games, scoring in each of those contests, with all being on the ground.
- After a down year from a rushing standpoint in 2025, McCaffrey is notching a 55.7% success rate that’s his highest since 2020 with the Carolina Panthers. His 4.7 yards per carry are his most since 2023.
- CMC averages 2.92 yards after contact per attempt. Those figures were 2.75 and 2.70, respectively, in the last two campaigns.
- Sharp Football Analysis relays that McCaffrey’s share of rushes of 10+ yards (16.4%) is third. His clip of carries that didn’t gain yardage (11.5%) is fifth lowest.
- For RBs with 25+ touches McCaffrey trails only R.J. Harvey of the Denver Broncos (18.3%) with his 18.2% target share. Moreover, his 58.4% route rate is seventh.
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Add Christian McCaffrey + 49ers to cover the spread to your PrizePicks lineup now.
49ers TE George Kittle vs. Commanders: 0.5 Anytime TDs (Demon)
- Between Weeks 2-4, George Kittle combined for 14 receptions, 232 yards, and 4 TDs as a pass catcher.
- Kittle has particularly been productive in the red zone where, per 4for4, he’s 6-for-6 on targets with 52 yards and 3 TDs.
- San Francisco owns football’s fifth-highest pass rate over expected (2.9%, via nfelo), so there could be ample openings for Kittle to stuff the stat sheet on MNF.
- Even while lining up in the slot at a personal-low 26.0% rate, Kittle is managing 2.33 yards per route run and 7.2 YAC per reception.
- Washington surrenders more fantasy PPG to TEs than all but one team at 15.8, influenced by 372 yards (seventh) and 7 TDs (second).
Add George Kittle + 49ers to win to your PrizePicks lineup now.
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The Washington offense suddenly looks much more competent with Daniels on the field and (mostly) healthy, and San Fran has boasted one of football’s most lethal attacks all season long. In a potentially high-scoring affair, which players track to potentially sniff pay dirt?
Don’t wait until kickoff — make your Commanders vs. 49ers picks on PrizePicks now and earn real money if you’re right.
Pick players, predict More or Less on their stats (including Anytime TDs), and cash in if you’re right. With Team Picks, you can make predictions on NFL game winners, spreads, and over/unders, now available in 36 states.
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