Best Bills vs. Rams Anytime TD Scorer Predictions for Monday Night Football

Might the NFL have saved its best Week 5 matchup for last? A Monday Night Football clash of AFC and NFC titans takes place to close out the slate when the Buffalo Bills and Los Angeles Rams do battle at 8:15 p.m. ET on ESPN and ABC.

Under new head coach Joe Brady, Buffalo has maintained its elite status on offense and continued to produce efficient results with star QB Josh Allen and RB James Cook at the helm. On the other sideline, head coach Sean McVay and reigning MVP QB Matthew Stafford are always a potent combo. 

Who else could stand out by finding pay dirt on MNF?

Below, we'll highlight our best Bills vs. Rams Anytime TD scorer predictions for Monday Night Football, including three players who could reach the end zone.

Make your Bills vs. Rams Anytime TD scorer picks on PrizePicks now.

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Bills vs. Rams Anytime TD Scorer Picks for Monday Night Football – October 12

Even with Allen not playing his best football, this Buffalo offense is still extremely scary. Through Brady’s first month as the HC in town, the Bills rank third in points per drive and have gained more yards than all but six NFL teams. Advanced metrics also back up the red-hot start; per RBSDM, Buffalo leads the league in EPA per play with 0.204. 

The Rams have had a strange season to this point, as Stafford isn’t putting up his normal numbers and WR Puka Nacua isn’t 100% healthy. Still, L.A. has racked up the most yards in the sport and owns a 46.3% success rate that’s good for ninth. 

Both the Bills and Rams have firepower at the team level, but it’s the individual pieces that figure to turn heads on Monday. Three, in particular, grab this writer’s attention as potential touchdown scorer picks. 

Anytime TDs on PrizePicks include rushing, receiving, recoveries, and returns. PrizePicks often list Anytime TDs as Demons and Goblins, meaning users can only select "More." For standard projections, users can select “More” or “Less.”

Demons are tougher to win but are the only way to get higher payouts. Meanwhile, Goblins are lower than a standard projection, but they are easier to win, so there’s a lower payout.

Bills RB James Cook vs. Rams: 0.5 Anytime TDs

• The Bills’ star halfback is as elusive as ever, breaking off 15 runs of 10+ yards and notching a 38.7% breakaway run rate. The latter is his best mark since 2022, which was his first year in the NFL. 
• Cook’s been worth the third-most total EPA (6.76) among all RBs this year, according to SumerSports.
• After rushing for a healthy 5.2 yards per carry in 2025, Cook’s taken things to a whole new level this year by amassing 6.0 YPC and a 57.1% success rate. 
• Per Fantasy Points Data, Buffalo owns the highest RB yards before contact per attempt mark (4.12) in the site’s history. The next-closest club is last year’s Baltimore Ravens (3.09). 
• Via NFL Pro, the Bills accumulate 6.0 YPC on man-concept runs. Los Angeles’ defense surrenders 4.6 YPC on such tries, the 10th-highest figure leaguewide. 

Add James Cook + Bills to win to your PrizePicks lineup now.

Rams RB Kyren Williams vs. Bills: 0.5 Anytime TDs (Goblin)

• In year five, Williams’ 64.8% rushing success rate tops the entire league. He now gets to take on a Bills rush defense that gives up the second-highest success clip at 45.3%. 
• Williams’ share of backfield touches has steadily improved each game, going from 47% and 52% in Weeks 1 and 2 to 75% and 81% in Weeks 3 and 4. 
• Inside the 10-yard line, Williams has logged 77.8% of the Rams’ rushing attempts, per 4for4. That puts him sixth in the league, also resulting in 21 yards and 3 TDs.
• In addition to not being hit at or behind the line of scrimmage much, Williams excels in creating yards after contact (3.76 per attempt, via SFdata9ers). 
• Buffalo cedes the fifth-most fantasy points per game to RBs at 22.7, largely due to 3 TDs apiece on the ground and through the air. 

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Add Kyren Williams + Rams to cover the spread to your PrizePicks lineup now.

Rams WR Davante Adams vs. Bills: 0.5 Anytime TDs

• Despite being 13 years into his career, Adams is making his receptions count more now than ever. His 17.7 yards per catch mark is the highest of his NFL tenure.
• Targets aren’t much of an issue for the grizzled vet; his 24.36% share is 20th at the WR position.
• Adams was an absolute menace inside the red zone a year ago, hauling in a league-leading 12 TDs on 13 receptions.
• According to Pro Football Focus, Stafford-to-Adams throws yield 0.49 EPA/play and a 10.5% big-time throw clip this year.  
• Sharp Football Analysis notes that the Bills allow 9.0 catches each week to outside WRs with an overall 9.3% TD rate. Adams spends the vast majority of his snaps on the boundary of the formation. 

Add Davante Adams + Rams to win to your PrizePicks lineup now.

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Whenever Buffalo or Los Angeles takes the field, fireworks typically ensue. On MNF, a collision course between Brady and McVay’s squads might just provide football fans with the game of the week. Several players, including the Cook-Williams-Adams trio, have avenues to putting points on the board. 

Don’t wait until kickoff — make your Bills vs. Rams picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats (including Anytime TDs), and cash in if you’re right. With Team Picks, you can make predictions on NFL game winners, spreads, and over/unders, now available in 36 states.

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